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Science, Volume 387, Issue 6737, Page 995-1000, February 2025.

Science, Volume 387, Issue 6737, Page 967-973, February 2025.

Science, Volume 387, Issue 6737, Page 984-989, February 2025.

Science, Volume 387, Issue 6737, Page 955-962, February 2025.

Science, Volume 387, Issue 6737, Page 933-933, February 2025.

Science, Volume 387, Issue 6737, Page 934-934, February 2025.

“Cost efficiency” order could block travel, supplies for labs and patient care

Ultra–high-power particle pulses could boost x-ray science and laboratory astrophysics

Combining remote cameras with GPS tracking gives scientists powerful tool to look at early lives of these elusive animals

The Amazon's Shuar nation teams up with scientists to authenticate shrunken heads, or tsantsas—and one day bring them home

The latest in science and policy

Genetic analysis of women who fled war-torn Syria and their descendants reveals potential genetic stress markers

Study highlights powerful role subjective choices can play in research, though some critics urge caution about applying findings too broadly

Alzheimer's disease (AD) is the most common form of dementia with continuum of disease progression of increasing severity from subjective cognitive decline (SCD) to mild cognitive impairment (MCI) and lastly to AD. The transition from MCI to AD has been linked to brain hypersynchronization, but the underlying mechanisms leading to this are unknown. Here, we hypothesized that excessive excitation in AD disease progression would shift brain dynamics toward supercriticality across an extended...

Dysregulation of mitochondrial function has been implicated in Parkinson's disease (PD), but the role of mitochondrial metabolism in disease pathogenesis remains to be elucidated. Using an unbiased metabolomic analysis of purified mitochondria, we identified alterations in α-ketoglutarate dehydrogenase (KGDH) pathway upon loss of PD-linked CHCHD2 protein. KGDH, a rate-limiting enzyme complex in the tricarboxylic acid cycle, was decreased in CHCHD2-deficient male mouse brains and human...

THIK-1 (KCNK13) is a halothane-inhibited and anionic-lipid-activated two-pore domain (K2P) K^(+) channel implicated in microglial activation and neuroinflammation, and a current target for the treatment of neurodegenerative disorders, for example Alzheimer's disease and amyothropic lateral sclerosis (ALS). However, compared to other K2P channels, little is known about the structural and functional properties of THIK-1. Here we present a 3.16-Å-resolution cryo-EM structure of human THIK-1 that...

We previously demonstrated that viral vector-mediated striatal Ca(V)1.3 calcium channel downregulation in young adult (3mo) male parkinsonian rats provides uniform, robust protection against levodopa-induced dyskinesias (LID). Acknowledging the association of PD with aging and incidence in male and female sexes, we have expanded our studies to include rats of advancing age of both sexes. The current study directly contrasts age and sex, determining their impact on efficacy of intrastriatal...

Cellular senescence and hypoxia-inducible factor (HIF) signaling are crucial in pulmonary aging and age-related lung diseases such as chronic obstructive pulmonary disease idiopathic pulmonary fibrosis and lung cancer. HIF plays a pivotal role in cellular adaptation to hypoxia, regulating processes like angiogenesis, metabolism, and inflammation. Meanwhile, cellular senescence leads to irreversible cell cycle arrest, triggering the senescence-associated secretory phenotype which contributes to...

Aging and metabolic disorders share intricate molecular pathways, with the Forkhead box O (FOXO)- Sirtuin 1 (SIRT1) axis emerging as a pivotal regulator of cellular stress adaptation, metabolic homeostasis, and longevity. This axis integrates nutrient signaling with oxidative stress defence, modulating glucose and lipid metabolism, mitochondrial function, and autophagy to maintain cellular stability. FOXO transcription factors, regulated by SIRT1 deacetylation, enhance antioxidant defence...

CONCLUSION: Walking speed and CRP levels are critical determinants in evaluating the risk of MetS in older adults; improving walking speed and mitigating inflammation may contribute to a decreased risk of MetS.