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U.K. science funding to remain flat for next 4 years
Government also announces cash for nuclear, carbon capture, and AI projects
A near-real-time data-assimilative model of the solar corona
Science, Volume 388, Issue 6753, Page 1306-1310, June 2025.
Neuroprotective and cognitive benefits of Semaglutide: Insights into the underlying molecular mechanisms
Neuronal injury is a common complication in patients with diabetes. These injuries include a wide range of neurobehavioral complications that significantly reduce the neuronal network efficiency and quality of life in affected individuals. Currently, diabetes-induced neuronal complications are a major global health challenge, and many studies have been performed to prevent or slow their progression. Semaglutide is a novel form of glucagon-like peptide-1 (GLP-1) agonist agents that has recently...
Dementia is deadly - the UN needs to take it more seriously
No abstract
Unraveling Alzheimer's complexity with a distinct Abeta(42) fibril type and specific AV-45 binding
Abnormal aggregation of amyloid-β protein (1-42) (Aβ(42)) is the primary pathology in Alzheimer's disease (AD). Two types of Aβ(42) fibrils have been identified in the insoluble fraction of diseased human brains. Here, we report that the fraction previously deemed 'soluble' during sarkosyl extraction of AD brains actually harbors numerous amyloid fibrils, with a looser bundling than those in the insoluble fraction. Using cryo-electron microscopy (cryo-EM), we discover a third type (type III) of...
Daily briefing: The energy-drink ingredient taurine doesn't seem to boost lifespan after all
No abstract
Recurrent somatic mutation and progerin expression in early vascular aging of chronic kidney disease
Early vascular aging plays a central role in chronic kidney disease (CKD), but its molecular causes remain unclear. Somatic mutations accumulate in various cells with age, yet their functional contribution to aging tissues is not well understood. Here we found progerin, the protein responsible for the premature aging disease Hutchinson-Gilford progeria syndrome, steadily recurring in vascular smooth muscle cells of patients with CKD. Notably, the most common progeria-causing mutation, LMNA...
Senescence-related proteins in blood predict aging traits
No abstract
Activity-dependent synapse elimination requires caspase-3 activation
During brain development, synapses are initially formed in excess and are later eliminated in an activity-dependent manner. Weak synapses are preferentially removed, but the mechanism linking neuronal activity to synapse removal is unclear. Here, we show that, in the developing mouse visual pathway, inhibiting synaptic transmission induces postsynaptic activation of caspase-3. Caspase-3 deficiency results in defects in synapse elimination driven by both spontaneous and experience-dependent...
Correction to "Defective Dimerization of FoF1-ATP Synthase Secondary to Glycation Favors Mitochondrial Energy Deficiency in Cardiomyocytes During Aging"
No abstract
Ligand-specific regulation of a binary enhancer code dictating cellular senescence
Cellular senescence, a major contributor to aging and age-related pathologies, is characterized by irreversible proliferative arrest and a disease-linked, proinflammatory profile known as the Senescence Associated Secretory Phenotype (SASP). A critical unanswered question is whether these properties are regulated by specific enhancer subsets, potentially licensing strategies that selectively block deleterious SASP components. Here, we identify two functionally distinct and independently...
Prevalence and Associated Factors of Depressive Symptoms and Major Depressive Disorder Among the Oldest-Old in India
CONCLUSIONS: Depression was prevalent among the oldest-old in India. Appropriate intervention strategies should be applied to prevent MMD among the oldest-old in India.
Brain DNA Methylation Age, Lifestyle Factors and Dementia in the Swedish Twin Registry
Advanced age is the most important risk factor for dementia. Measures of biological ageing such as DNA methylation age (DNAmAge) can give more information about the accumulation of age-related molecular damage in different organs than chronological age alone. Using post-mortem brain tissue from Swedish Twin Registry participants, we explored the relationship between lifestyle factors, dementia and DNAmAge measures from prefrontal cortex and cerebellum (n = 27 individuals) and paired blood...