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CD8^(+) T cells exhibit distinct changes with aging, including a diminished naïve cell pool, an expansion of memory and exhausted cells, and altered effector molecule production, altogether leading to increased susceptibility to infection. They have reduced cytotoxicity in vivo, but increased granule content and faster cytotoxic kinetics to target cells in vitro. Whether CD8^(+) T cells from old mice degranulate when activated in vivo, within the aged environment, is unknown. This study...

Gait alterations are recognized as early markers of age-related decline and cognitive impairment. Dual-task assessments, which impose cognitive load while walking, provide valuable insights into gait control limitations and cognitive-motor interactions in aging populations. This study evaluates age-related and cognitive load-induced changes in gait parameters, with a particular focus on asymmetry, and aims to optimize the gait assessment protocol for the Semmelweis Study framework. The...

The age-associated neurodegenerative disorder, Lewy body dementia (LBD), encompasses neuropsychiatric symptom-overlapping Dementia with Lewy bodies (DLB) and Parkinson's Disease with Dementia (PDD). We characterised how differential mitochondrial DNA (mtDNA) profiles contribute to neurotype-specific neurodegeneration and thereby clinicopathological heterogeneity, between LBD's syndromes. We further characterised key nuclear-encoding genes' recalibrations in response to such mtDNA changes. In...

Multiple studies in mice with genetically disrupted growth hormone (GH) signaling have demonstrated that such disruption results in reduced body size, robustly increased longevity (> 50% in some cases), and improvements across multiple health parameters. However, it remains unclear how generalizable these findings are across mammals. Evidence in rats is limited and inconsistent. These conflicting results highlight the need for further investigation into the role of GH signaling in longevity...

CONCLUSIONS: Frailty trajectories at the end of life varied by cause of death, with neurodegenerative disease decedents exhibiting more severe frailty. These findings underscored the need for early identification of frailty and tailored end-of-life care strategies, particularly for individuals with neurodegenerative diseases who often experienced prolonged and severe frailty.

CONCLUSION: Despite trends of decreased functional specialization in aging, and prior evidence within this cohort of broad task-related activation and connectivity bilaterally, semantic task relevance remained uniquely localized to left hemisphere semantic network hubs. Increased coherence within DAN and DMN during rhyme blocks may reflect novelty of the rhyming task, underscoring flexible network recruitment for demanding tasks in healthy aging. Findings contribute to our understanding of...

CONCLUSIONS: Markers of inflammation were associated with multisensory impairment, but there were fewer associations with individual sensory impairments.

Economic collapse in Palestinian territories has led to illegal digs at prominent Bronze Age site, new study finds

Williams College says NSF and NIH requirement related to discrimination “undermines” academic freedom

Scientists film nematodes forming a superorganism in the wild for the first time