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Connecting the dots: microstructural properties of white matter hyperintensities predict longitudinal cognitive changes in ageing

3 months ago
This study investigates the relationship between white matter hyperintensities (WMHs) and longitudinal cognitive decline in older adults. Using data from The Irish Longitudinal Study on Ageing (TILDA), we examined WMH characteristics, including volume, location, and microstructural integrity, in a community-dwelling population of 497 individuals over a six-year period. WMHs were categorised into phenotypes based on their size, fractional anisotropy (FA), and mean diffusivity (MD), with subtypes...
Michael Courtney

Relationship between Body Roundness Index and cognitive impairment in middle-aged and older adults: a population-based cross-sectional study

3 months ago
CONCLUSION: Body Roundness Index, in conjunction with age, gender, and hypertension, can serve as a useful predictor of cognitive impairment, particularly in younger populations. Early identification of individuals at risk through BRI may facilitate timely interventions, reducing the burden of cognitive decline on patients and healthcare systems.
Dandan Guo

Talking during walking: the diagnostic potential of turn dynamics in Alzheimer's disease, mild cognitive impairment and cognitive aging

3 months ago
CONCLUSION: In contrast to straight walk metrics, this study shows that DTWT turn dynamics are more sensitive to detect cognitive impairment. Consequently, incorporating turning movements into gait analysis techniques could enhance diagnostic protocols in clinical settings, offering a valuable tool for monitoring the progression of conditions associated with cognitive aging.
Hedieh Mohammadi

Simulated driving behavior over the adult age span

3 months ago
CONCLUSION: With rich detail arising from intra-task quantification, the results were consistent with and additive to previous literature showcasing that compared to middle-aged adults, young adults showed performance suggestive of riskier driving behavior, and old adults showed performance suggestive of caution consequent to declining driving ability. In particular, the intra-task quantification revealed that the driving of young adults was more impacted by the presence of distraction (e.g.,...
Felix Menze

In Science Journals

3 months ago
Science, Volume 387, Issue 6738, Page 1049-1051, March 2025.

Michael Funk, and
Leslie K. Ferrarelli,
Jake S. Yeston,
Bianca Lopez,
Yury Suleymanov,
Di Jiang,
Corinne Simonti,
Courtney Malo,
Stella M. Hurtley,
Christiana N. Fogg,
Caroline Ash,
Phil Szuromi, and
Marc S. Lavine