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Daily briefing: AlphaFold reveals ‘family tree’ of viruses
Should young kids take the new anti-obesity drugs? What the research says
‘The standard model is not dead’: ultra-precise particle measurement thrills physicists
A small fix to cut beer intake: downsize the pint
Author Correction: Fast-moving stars around an intermediate-mass black hole in ω Centauri
Doctors cured her sickle-cell disease. So why is she still in pain?
Unearthing ‘hidden’ science would help to tackle the world’s biggest problems
Stop delaying action on antimicrobial resistance — it is achievable and affordable
Tackling antimicrobial resistance needs a tailored approach — four specialists weigh in
40 million deaths by 2050: toll of drug-resistant infections to rise by 70%
AI model collapse might be prevented by studying human language transmission
To combat antimicrobial resistance, invest in test-to-treat strategies
My identity was stolen by a predatory conference
A triple rainbow all the way across the sky — 150 years ago
UN Pact for the Future: Scientists must step up to accelerate sustainability goals
Pediatrics academy accused of “fearmongering” over GMO ingredients in kids’ diets
New guidelines asserting pesticide dangers wrongly favor organic foods over cheaper ones, critics say
In the dark ocean, these tiny creatures can smell their way home
Commuting crustaceans can sense water from the caves where they live
Olfactory deficit and gastrointestinal dysfunction precede motor abnormalities in alpha-Synuclein G51D knock-in mice
Parkinson's disease (PD) is typically a sporadic late-onset disorder, which has made it difficult to model in mice. Several transgenic mouse models bearing mutations in SNCA, which encodes alpha-Synuclein (α-Syn), have been made, but these lines do not express SNCA in a physiologically accurate spatiotemporal pattern, which limits the ability of the mice to recapitulate the features of human PD. Here, we generated knock-in mice bearing the G51D SNCA mutation. After establishing that their motor...
Ageing, proteostasis, and the gut: Insights into neurological health and disease
Recent research has illuminated the profound bidirectional communication between the gastrointestinal tract and the brain, furthering our understanding of neurological ailments facilitating possible therapeutic strategies. Technological advancements in high-throughput sequencing and multi-omics have unveiled significant alterations in gut microbiota and their metabolites in various neurological disorders. This review provides a thorough analysis of the role of microbiome-gut-brain axis in...
Author Correction: Serum proteomics reveal APOE-epsilon4-dependent and APOE-epsilon4-independent protein signatures in Alzheimer's disease
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