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Behavior drives morphological change during human evolution
Science, Volume 389, Issue 6759, Page 488-493, July 2025.
A molecular machine directs the synthesis of a catenane
Science, Volume 389, Issue 6759, Page 526-531, July 2025.
Dust-driven droplet freezing explains cloud-top phase in the northern extratropics
Science, Volume 389, Issue 6759, Page 521-525, July 2025.
Pantropical tree rings show small effects of drought on stem growth
Science, Volume 389, Issue 6759, Page 532-538, July 2025.
Conserved noncoding cis elements associated with hibernation modulate metabolic and behavioral adaptations in mice
Science, Volume 389, Issue 6759, Page 501-507, July 2025.
Genomic convergence in hibernating mammals elucidates the genetics of metabolic regulation in the hypothalamus
Science, Volume 389, Issue 6759, Page 494-500, July 2025.
High-field superconducting halo in UTe2
Science, Volume 389, Issue 6759, Page 512-515, July 2025.
An American energy experiment
Science, Volume 389, Issue 6759, Page 462-462, July 2025.
Dead in Banaras: An Ethnography of Funeral Travelling
Science, Volume 389, Issue 6759, Page 463-463, July 2025.
Experiencing the Arctic
Science, Volume 389, Issue 6759, Page 463-463, July 2025.
With boost to NIH budget, Senate panel rejects Trump’s plan to slash agency
Republicans on spending committee push back against proposed reorganization and overhead cuts
The battle for Ukraine’s geological wealth
The nation’s vast deposits of critical minerals have drawn interest from Russia and the United States
Amid unrelenting attacks on Ukraine, mental health researchers seek to understand psychological toll
Studies of soldiers and civilians could provide clues to diagnosis and treatments
Civilian scientists are helping make Ukraine’s military more tech savvy
War with Russia is reshaping research on everything from exotic drones to trauma care
Our ape ancestors’ taste for fermenting fruit may have paved a boozy evolutionary path
Eating fallen fruit—or “scrumping”—plays a bigger part in many apes’ diets than scientists realized
Beavers are poised to invade and radically remake the Arctic
A warming climate is enabling rodents to move north
A human milk oligosaccharide alters the microbiome, circulating hormones, and metabolites in a randomized controlled trial of older adults
Aging-related immune dysfunction is linked to cancer, atherosclerosis, and neurodegenerative diseases. This 6-week randomized controlled trial evaluated whether 2'-fucosyllactose (2'-FL), a human breast milk oligosaccharide with established benefits in infants and animal models, could improve gut microbiota and immune function in 89 healthy older adults (mean age 67.3 years). While the primary endpoint of cytokine response change was not met, 2'-FL supplementation increased gut Bifidobacterium...
Asynchronous aging and turnover of human circulating and tissue-resident memory T cells across sites
Memory T cells are maintained in tissues as circulating effector-memory (T(EM)) and tissue-resident (T(RM)) populations for protective immunity, though the role of site and subset in memory persistence remains undefined. Here, we investigated age-associated dynamics of human T cells in lymphoid organs, mucosal sites, and blood over 10 decades of life using retrospective radiocarbon (^(14)C) birth dating, along with cellular, transcriptome, and epigenetic profiling. Memory T cells across...
Alternative Polyadenylation Contributes to Fibroblast Senescence in Pulmonary Fibrosis
Idiopathic pulmonary fibrosis (IPF) is a prevalent and deadly age-related disease characterized by chronic, progressive, and irreversible fibrosis. A key effector cell population in the fibroproliferative response is the fibroblasts. Fibroblast cell senescence gradually worsens during aging, and the acquisition of a senescence-associated secretory phenotype (SASP) turns senescent fibroblasts into pro-inflammatory cells. However, the mechanism promoting senescence in IPF, especially at the...
The acute response of irisin to resistance and endurance exercise at both lower and higher intensities in healthy older adults
Exercise-induced release of irisin may contribute to the beneficial effects of exercise on brain health. Previous studies in healthy adults have shown ~15 % increase in short-term post-exercise irisin concentrations. However, previous research investigating the exercise-induced release of irisin in older populations is scarce and findings are highly variable. The present study investigated the effects of exercise mode and intensity on short-term acute post-exercise irisin concentrations in older...