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Aging is associated with a gradual decline in cellular function, largely driven by oxidative stress, which leads to cellular senescence. These processes contribute to tissue degeneration and age-related dysfunction. Human dermal fibroblasts (HDFs), critical for maintaining skin structure, are highly vulnerable to oxidative damage, making them key contributors to skin aging. Umbilical cord blood plasma (UCBP), rich in growth factors and regenerative molecules, has shown potential in preventing...

Agency will make researchers outside United States seek grants of their own rather than “subawards” from U.S. scientists

Key research budgets would shrink by one-third to one-half in 2026 spending plan

Critics say the report, which declines to disclose its authors, contradicts decades of scientific research

Courts have blocked attempts by NIH and DOE to impose a flat 15% rate for reimbursement

Phenomenon behind heavy element creation has been a mystery for 2 decades

Dissolving skeletons would boost oceans’ ability to soak up carbon dioxide

As the second Trump administration sends U.S. science into upheaval, countless researchers are fighting for their futures

Microglia and border-associated macrophages (BAMs) are critical for brain health, and their dysfunction is associated to disease. Replacing brain macrophages holds substantial therapeutic promise but remains challenging. Here, we demonstrate that monocytes can efficiently replace all brain macrophages. Monocytes readily replaced embryonal BAMs upon their depletion and engrafted as monocyte-derived microglia (Mo-Microglia) upon more sustained niche availability. Mo-Microglia expanded comparably...