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Daily briefing: Key coral species are functionally extinct after record-breaking heatwave
China seeks self-reliance in science in next five-year plan
The sci-fi films that physicists love to watch — from <i>Interstellar</i> to <i>Spider-Man</i>
How Napoleon’s army met its doom: DNA reveals surprise illnesses had a role
AI chatbots are sycophants — researchers say it’s harming science
Chen-Ning Yang obituary: intuitive physicist whose work was inspired by the beauty of symmetry
Ancient graffiti and brain complexities: Books in brief
Sugarcane genomes offer sweet surprise: mystery ancestor
Audio long read: How to get the best night’s sleep — what the science says
How to grow crystals when and where you want them
Single-cell analysis of human thymus and peripheral blood unveils the dynamics of T cell development and aging
Fat modifications protect joints from degrading
Paper or plastic?
Justice Department unexpectedly drops fraud case against Alzheimer’s scientist
Decision comes after disclosure of university letter concluding Hoau-Yan Wang did not engage in misconduct
Rats filmed snatching bats from air for first time
Stunning hunting behaviour captured in German cave
Ambient noise can track dangerous ocean acidification
Acoustic technique could make it easier to monitor threat to marine life stemming from rising carbon emissions
Fat-chomping enzyme that ‘moonlights’ as gene regulator could point to obesity treatments
Hormone-sensitive lipase works in the nucleus to keep fat cells healthy, new study suggests
A glial circadian gene expression atlas reveals cell-type and disease-specific reprogramming in response to amyloid pathology or aging
While circadian rhythm disruption may promote neurodegenerative disease, the impact of aging and neurodegenerative pathology on circadian gene expression patterns in different brain cell types remains unknown. Here we used a translating ribosome affinity purification to identify the circadian translatomes of astrocytes, microglia and bulk tissue in healthy mouse cortex and in the settings of amyloid-β plaque pathology or aging. We show that glial circadian translatomes are highly...
A glial circadian gene expression atlas reveals cell-type and disease-specific reprogramming in response to amyloid pathology or aging
While circadian rhythm disruption may promote neurodegenerative disease, the impact of aging and neurodegenerative pathology on circadian gene expression patterns in different brain cell types remains unknown. Here we used a translating ribosome affinity purification to identify the circadian translatomes of astrocytes, microglia and bulk tissue in healthy mouse cortex and in the settings of amyloid-β plaque pathology or aging. We show that glial circadian translatomes are highly...
Unravelling the association between internet use and loneliness among Chinese older adults during the COVID-19 pandemic: the role of potentially moderating and mediating factors
CONCLUSIONS: These findings highlight the potential of Internet use as an intervention to mitigate loneliness among older adults during major public health crises, such as the COVID-19, by promoting social participation and online social contact. This provides an implication for developing strategies to support the older population during future crises.