Aggregator
TLR7 Mediates HIV-1 Tat-Induced Cellular Senescence in Human Astrocytes
Cellular senescence contributes to accelerated aging, neuroinflammation, and the development of HIV-associated neurocognitive disorders (HAND) in the era of combined antiretroviral therapy (cART). One HIV viral factor that could lead to cellular senescence is the persistence of HIV-1 Tat in the brain. As a secreted viral protein, Tat is known to enter endolysosomes of cells through receptor-mediated endocytosis, and we have shown that Tat induces endolysosome damage and dysfunction....
Impact of enlarged perivascular spaces in the basal ganglia on gait in cerebral small vessel disease
CONCLUSION: BG-EPVS is independently associated with gait disturbances in both CSVD patients and the elderly. These findings underscore the importance of early gait assessment in the aging population. Further longitudinal research is needed to confirm these associations.
The road to a long lifespan in the Persian squirrel, a natural model for extended longevity: resisting free radical stress and healthy phospholipids
Longevity is influenced by various factors, including fatty acid composition and free radical stress, which relate to the membrane pacemaker and rate of living hypotheses. While these aspects are well-documented in some long-lived species, they remain largely unexplored in tree squirrels. This study aimed to compare oxidative stress, antioxidant activity, nitrosative stress, and lipid composition between the long-lived Persian squirrel (Sciurus anomalus) and the short-lived Wistar rat across age...
Leukocyte telomere attrition in cognitive decline: associations with APOE genotype and cardiovascular risk factors
Telomere shortening represents a fundamental mechanism of cellular aging potentially implicated in neurodegenerative processes. This study investigated the complex associations among leukocyte telomere length, cardiovascular risk profiles, and APOE polymorphisms in age-related cognitive decline. Through a cross-sectional analysis of 90 participants stratified by cognitive status into three groups: cognitively unimpaired (CU), mild cognitive impairment (MCI), and Alzheimer's Disease (AD), we...
Immune Resilience: Rewriting the Rules of Healthy Aging
Aging is typically framed by disease, not resilience. This Perspective highlights immune resilience (IR) as a core determinant of healthy aging, based on new findings linking TCF7-driven immune profiles to extended healthspan and lifespan. IR buffers against immunosenescence, inflammaging, and senescent cell phenotypes, with benefits most pronounced before age 70. By reframing aging around salutogenesis rather than pathogenesis, this work shifts the focus toward resilience mechanisms and...