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Google DeepMind won a Nobel prize for AI: can it produce the next big breakthrough?
Bill Gates’s climate comments are a dangerous distraction
The UK must not lose its focus on science and innovation
Honouring visionary scientist and <i>Nature</i>’s founder, Norman Lockyer
Author Correction: Brahma safeguards canalization of cardiac mesoderm differentiation
Beyond growth — why we need to agree on an alternative to GDP now
Nations at COP30 must cancel fossil-fuel concessions to keep the Paris agreement in reach
Fishing around offshore wind farms could boost both conservation and green energy
Leaders at COP30 should promote solar and wind power over mega-dams
Panels of peers are needed to gauge AI’s trustworthiness — experts are not enough
Curious gravitational wave may be hint at primordial black holes—or just noise
Astronomers approach unusual observation with caution and excitement
High-resolution climate model forecasts a wet, turbulent future
With details as fine as short-term weather forecasts, model achieves newfound accuracy
Lab-grown models of human brains are advancing rapidly. Can ethics keep pace?
Whether neural organoids feel pain or should be placed in animals are among the questions swirling around biology’s hot new technology
Radar data find no decline in insect numbers—but there’s a catch
Study of continental U.S. sees stable population of bugs, but it may be missing important pieces of the puzzle
Giant telescope project, long planned for Hawaii, gets cozy with Spain
Spain’s €400 million offer could induce Thirty Meter Telescope to switch sites
Have wild wolves learned to use tools?
Video captures a lone female pulling crab traps out of the water, but does it count as tool use?
Chromosome duplication causes premature aging via defects in ribosome quality control
Down syndrome, caused by an extra copy of Chromosome 21, causes lifelong problems. One of the most common phenotypes among people with Down syndrome is premature aging, including early tissue decline, neurodegeneration, and shortened life span. Yet the reasons for premature systemic aging are a mystery and difficult to study in humans. Here we show that chromosome amplification in wild yeast also produces premature aging and shortens life span. Chromosome duplication disrupts nutrient-induced...
Polycomb misregulation in enterocytes drives tissue decline in the aging <em>Drosophila</em> intestine
Aging compromises intestinal integrity, yet the chromatin changes driving this decline remain unclear. Polycomb-mediated repression is essential for silencing developmental genes, but this regulatory mechanism becomes dysregulated with age. Although shifts in Polycomb regulation within intestinal stem cells have been linked to gut aging, the Polycomb landscape of differentiated cell types remains unexplored. Differentiated cells comprise the majority of the gut epithelium and directly impact...
Association between serum uric acid and frailty: Evidence from NHANES database and perioperative geriatric frailty cohort
CONCLUSIONS: SUA is significantly associated with frailty in both community and surgical populations. In community population, a U-shaped relationship was observed, whereas only high SUA levels predict frailty perioperatively. Females are more susceptible to SUA-related frailty.
Multivariate genome-wide analyses of insulin resistance unravel novel loci and therapeutic targets for cardiometabolic health
Limited identification of insulin resistance-associated loci hinders understanding of its role in cardiometabolic health, impeding therapeutic strategies. We apply three multivariate genome-wide association study approaches on homeostatic model assessment for insulin resistance, insulin resistance index, fasting insulin, and ratio of triglycerides to high-density lipoprotein cholesterol from MAGIC and UK Biobank to develop a comprehensive phenotype ('mvIR'), and identify 217 independent loci,...