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A history of hocus pocus: witchcraft down the ages
Author Correction: Increasingly negative tropical water–interannual CO<sub>2</sub> growth rate coupling
Ontogeny and transcriptional regulation of Thetis cells
Treatment resistance to platinum-based chemotherapy in lung and ovarian cancer is driven by a targetable TGFβ senescent secretome
Aging clocks delineate neuron types vulnerable or resilient to neurodegeneration and identify neuroprotective interventions
Precision targeting of the SASP in cancer therapy
The global plastics treaty can be saved — here’s how to break the deadlock
Who does academic consulting serve?
Calling all scientists: Support your Iranian colleagues
Embrace diverse PhD supervision styles — but enforce essential standards
Loss of ‘hunger hormone’ has made snakes masters of fasting
Ditching ghrelin genes may have helped a wide variety of reptiles deal with a boom-or-bust feeding schedule
Senate panel slams Trump’s NIH chief for grant cuts, vaccine views
Lawmakers on both sides of the aisle decry disruptions to biomedical research under Jay Bhattacharya
Brain cells birth zombielike transport vesicles
Shed from the surfaces of astrocytes, “zombosomes” flit between cells, carrying proteins linked to disease
As the world warms, freezing rain shifts to the U.S. South
Recent winter storm traced the path of an emerging ice corridor
Lawmakers spend big on home state science projects
Kentucky Senator Mitch McConnell, king of congressional earmarks, steers $165 million to his alma maters
Associations of chinese-modified MIND diet with low muscle mass and physical performance among old adults in china: findings from the CLHLS 2018 national survey
CONCLUSION: Greater adherence to the cMIND dietary pattern is independently associated with lower probability of LMM and better physical performance among older Chinese adults. These findings suggest potential benefits of promoting MIND diet principles for maintaining musculoskeletal health in aging populations.
Selective peroxynitrite-mediated protein nitration catalyzed by glyoxalase domain containing protein 4
Tyrosine nitration alters the structure, function, and cellular localization of proteins and is implicated in the pathology of multiple diseases [G. Ferrer-Sueta et al., Chem. Rev. 118, 1338-1408 (2018), H. Ischiropoulos, Arch. Biochem. Biophys. 356, 1-11 (1998), I. Griswold-Prenner et al., J. Biol. Chem. 299, 105038-10554 (2023)]. Although protein nitration is assumed to proceed via nonspecific chemical mechanisms, it is highly selective, suggesting the possibility of enzymatic catalysis. Here,...
PTP1B inhibition promotes microglial phagocytosis in Alzheimer's disease models by enhancing SYK signaling
Amyloid β (Aβ) accumulation is a hallmark of Alzheimer's disease (AD). Emerging evidence suggests that impaired microglial Aβ phagocytosis is a key feature in AD, highlighting the therapeutic potential of enhancing this innate immune function. Here, we demonstrate that genetic deletion or pharmacological inhibition of protein tyrosine phosphatase 1B (PTP1B) ameliorated memory deficits and reduced Aβ burden in APP/PS1 mice. Moreover, we show that PTP1B was highly expressed in microglia, and its...
Dopamine antagonists-induced parkinsonism: the crucial role of individual susceptibility associated to positive family history
No abstract
A common 19 bp APOE enhancer deletion is protective against Alzheimer's disease in African Americans
The APOE-ε4/ε4 genotype is the strongest genetic risk factor for sporadic Alzheimer's disease, though the relative risk is diminished in individuals with African ancestry. Through analysis of phased APOE alleles, we identify a 19 bp deletion approximately 1.1 kb distal to the APOE 3'UTR in a SPI1 microglial transcription factor binding site. The deletion is present in 60% of African American APOE-ε4 homozygotes and reduces Alzheimer's disease odds ratio relative to individuals without the...