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Extracellular salt bridge networks around S4 implicated in HCN channel gating and heart disease

3 months ago
The hyperpolarization-activated cyclic nucleotide-gated (HCN) channel is a voltage-gated cation channel that plays a crucial role in regulating cellular excitability, especially in cardiac pacemaker cells and neurons. Its dysregulation is linked to heart diseases such as bradycardia and neurological disorders such as epilepsy, Parkinson's disease, and neuropathic pain. Structural and functional studies have revealed that the S4 voltage sensor of the HCN channel moves downward during...
Kaei Ryu

Effects of age and musical training on resting-state periodic oscillatory brain activity

3 months ago
Neural oscillations comprise periodic and aperiodic components, which have been linked to cognitive functions. Changes in oscillatory activity as a function of age and musical training may related to cognitive decline and the protective effects of lifelong musical training. However, there are inconsistencies in prior studies assessing the changes in alpha oscillations with age and musical training experience, which did not consider the putative impact of the aperiodic activity. In this study, we...
Sijia Guo

ApoD mediates age-associated increase in vulnerability to influenza virus infection

3 months ago
Influenza A virus (IAV) infection causes significantly greater morbidity and mortality in the elderly population, but the molecular mechanisms in the aging process responsible for severe infection remain unclear. In this study, we found that increased severity in IAV infection and reduced innate immune response correlated with extensive mitophagy in senescent human cells and in the lung of aged mice. Apolipoprotein D (ApoD) was identified as strongly elevated in the lungs and sera of aged human...
Zhimin Jiang

Entropy, Assessed by Homeostatic Dysregulation on Electrocardiograms Predicts Fracture and Mortality

3 months ago
Entropy, characterized by increased disorder throughout biological systems, can be quantified by homeostatic dysregulation (HD). One potential measure of HD is the dispersion of points from a normal value, approximated at the individual level by Mahalanobis distance (D(M)). We hypothesized that greater HD in electrocardiogram (ECG) would also reflect greater HD in the musculoskeletal system which, in turn, would be associated with age and manifest as an increased risk of fracture independently...
Namki Hong

Visual objects refine head direction coding

3 months ago
Science, Volume 389, Issue 6765, September 2025.
Dominique Siegenthaler, Henry Denny, Sofía Skromne Carrasco, Johanna Luise Mayer, Daniel Levenstein, Adrien Peyrache, Stuart Trenholm, Émilie Macé