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Nonlinear wave dynamics on a chip

3 months ago
Science, Volume 390, Issue 6771, Page 371-376, October 2025.
Matthew T. Reeves, Walter W. Wasserman, Raymond A. Harrison, Igor Marinković, Nicole Luu, Andreas Sawadsky, Yasmine L. Sfendla, Glen I. Harris, Warwick P. Bowen, Christopher G. Baker

Drought-induced peatland carbon loss exacerbated by elevated CO2 and warming

3 months ago
Science, Volume 390, Issue 6771, Page 367-370, October 2025.
Quan Quan, Jian Zhou, Paul J. Hanson, Daniel Ricciuto, Stephen D. Sebestyen, David J. Weston, Jeffrey P. Chanton, Rachel M. Wilson, Joel E. Kostka, Yu Zhou, Ning Wei, Lifen Jiang, Melanie A. Mayes, Jonathan M. Stelling, Andrew D. Richardson, Mirindi Eric…

Observation of the distribution of nuclear magnetization in a molecule

3 months ago
Science, Volume 390, Issue 6771, Page 386-389, October 2025.
S. G. Wilkins, S. M. Udrescu, M. Athanasakis-Kaklamanakis, R. F. Garcia Ruiz, M. Au, I. Belošević, R. Berger, M. L. Bissell, A. A. Breier, A. J. Brinson, K. Chrysalidis, T. E. Cocolios, R. P. de Groote, A. Dorne, K. T. Flanagan, S. Franchoo, K. Gaul, S…

Visualizing the chronicle of multiple cell fates using a near-IR dual-RNA/DNA-targeting probe

3 months 1 week ago
Early detection and late-stage cell fate assessment are key factors to develop therapeutic strategies, although current methods cannot capture early responses or distinguish multiple injury states, especially in ultraviolet-visible (UV-vis)-sensitive cells. Here, we introduce a method to simultaneously detect variations in RNA and DNA under near-infrared photoexcitation. Using a pyrazinacene-based probe (TEG(8)-N14), we unexpectedly achieved discrimination of multiple cell states, including...
Linawati Sutrisno

An optimized click chemistry method allows visualization of proliferating neuronal progenitors in the mouse brain

3 months 1 week ago
We establish a click reaction-based workflow (tissue clearing coupled with click-chemistry in 3D, C⁴-3D) to visualize 5-ethynyl-2'-deoxyuridine (EdU) in whole mouse brain tissue cleared by CUBIC, iDisco+, and PACT. C⁴-3D was compatible with immunostaining, nuclear staining, and a fluorescent reporter mouse. Machine learning-based identification of EdU-positive nuclear coordinates followed by normalization for the Allen Brain Atlas revealed that proliferating neuronal progenitors were enriched in...
Fei Zhao

Targeting VGLL4 maintains extracellular matrix homeostasis and mitigates osteoarthritis in a preclinical model

3 months 1 week ago
Extracellular matrix homeostasis is crucial for hyaline cartilage integrity, however, the mechanism of extracellular matrix homeostasis in hyaline cartilage is poorly understood. Single-cell sequencing shows that VGLL4 is highly expressed in chondrocytes but declines after injury/aging. VGLL4 deficiency impairs collagen/elastin formation, causes extracellular matrix disorganization and osteoarthritis in Col2-CreERT2; Vgll4^(fl/fl) mice, and is exacerbated by destabilization of the medial...
Jinlong Suo