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Science, Volume 389, Issue 6761, Page 716-719, August 2025.

Science, Volume 389, Issue 6761, Page 727-731, August 2025.

Science, Volume 389, Issue 6761, Page 691-691, August 2025.

Science, Volume 389, Issue 6761, Page 690-690, August 2025.

Science, Volume 390, Issue 6768, Page 88-94, October 2025.

Science, Volume 389, Issue 6765, Page 1122-1126, September 2025.

New footage provides rare insight into the daring migration of an enigmatic fish

The mysterious branch of life of known as archaea harbor unique bacteria-fighting compounds

Demo showcases new AI-powered tool of potential use in quantum computers

The cells could be a new source of tumor DNA for liquid biopsies

Dispute over elusive Majorana particles claimed in Science highlights controversial approach to robust quantum chips

Drug and chemical safety can be assessed with AI and organ chips, but some scientists say it’s too soon to forgo animal methods entirely

Scientists say the teeth belonged to a type of Australopithecus, a relative of Lucy’s species, that coexisted with our genus, Homo

Ruling comes as government seeks settlement with UCLA on larger set of suspended grants

Making use of an obscure physics effect to fly, devices could probe the upper atmosphere and explore Mars

The "Christchurch" protective variant in the APOE gene has recently been identified, but its mechanisms of action remain unknown. In this issue of Immunity, Naguib and Lopez-Lee et al. provide evidence for the APOE-Christchurch variant suppressing microglial cGAS-STING responses and increasing clearance of pathological tau aggregates in mouse models of Alzheimer's disease.

Hyposmia, a common non-motor symptom in Parkinson's disease (PD) linked to reduced odor sensitivity, is associated with brain structural and functional changes, but dynamic brain activity and altered regional information exchange remain underexplored, limiting insight into underlying brain states. We selected 15 PD patients with severe hyposmia (PD-SH), 15 PD patients with normal cognition (PD-CN), and 15 healthy controls (HC). Using functional MRI, we assessed the brain's spatiotemporal...

Aging is a series of adverse changes over time that increases mortality risk. Several hypotheses have been proposed to explain aging, including Leslie Orgel's Error-Catastrophe Theory, which asserts that translation errors erode the translational machinery, become self-amplifying, and eventually lead to death. Evidence for the theory is scarce, especially regarding intra-specific fidelity-longevity correlations. Here, we demonstrate that the correlation can be hidden by the constrained evolution...

The immune system comprises multiple cell lineages and subsets maintained in tissues throughout the lifespan, with unknown effects of tissue and age on immune cell function. Here we comprehensively profiled RNA and surface protein expression of over 1.25 million immune cells from blood and lymphoid and mucosal tissues from 24 organ donors aged 20-75 years. We annotated major lineages (T cells, B cells, innate lymphoid cells and myeloid cells) and corresponding subsets using a multimodal...

Calorie restriction (CR) improves health and longevity. CR induces a periodic fasting cycle in mammals; our study compares CR with unanticipated fasting (F), when the food is unexpectedly withheld. F induces hepatic steatosis, whereas CR reduces it; surprisingly, the difference is not due to hepatic β-oxidation. Liver transcriptome analysis identifies fatty acid transporters (Slc27a1 and Slc27a2), triglyceride (TAG) synthesis (Gpat4), and lipid storage (Plin2 and Cidec) genes to be upregulated...