Aggregator
ZC3H4, a novel regulator of mitochondrial complex I, impacts prostate stromal cell senescence, attachment, adhesion and anoikis resistance
Declining mitochondrial function is an established feature of aging and contributes to most aging-related diseases through its impact on various pathologies such as chronic inflammation, fibrosis and cellular senescence. Our recent work suggests that benign prostatic hyperplasia, which is an aging-related disease frequently associated with inflammation, fibrosis and senescence, is characterized by a decline in mitochondrial function. Here, we utilize glycolytic restriction and pharmacologic...
Daily briefing: People with macular degeneration can read again after retinal implant
US PhD admissions shrink as fears over Trump’s cuts take hold
Stinkbug ‘ear’ actually hosts parasite-fighting fungi
‘Gland-in-a-dish’ secretes stress hormone like the real thing
Universities are embracing AI: will students get smarter or stop thinking?
Hopes of realizing a dream ‘city of health’
Cake to the rescue: how these PhD students are cooking up a sense of community
The TrumpRx website won’t slash drug prices — but this will
Genetics can give evolving societies a leg up
The race for deep-sea minerals could cause geopolitical and ecological harm
Take the time to ensure that AI is safe
Brazil must beef up its COP30 scheme to preserve tropical forests
‘I fear we are sitting on a time bomb.’ Scientists debate mass distribution of antibiotics in Africa
Prophylactic use of azithromycin saves vulnerable children’s lives, but could trigger antibiotic resistance
‘It’s like a horror movie pregnancy.’ Researcher studies maggots—by letting them eat him
Science chats with wildlife epidemiologist Tony Goldberg about what he’s learned from becoming a meal for parasites
Lab mice can now have periods like humans
Studies of rodents with a menstrual on/off switch could help people with endometriosis and other disorders
Beetle compound is so valuable insects eat bird poop to get it
To obtain the toxic chemical cantharidin, insects suck beetles’ blood—and even munch on their digested remains
Difference between estimated GFR based on cystatin C versus creatinine and incident dementia, cognitive functions and biological aging: A cohort study of the UK Biobank
CONCLUSIONS: A negative eGFR(diff) (eGFR(cys)-eGFR(cr) < -15 mL/min/1.73m²) was associated with a higher risk of dementia, poorer cognitive functions, and worse biological age acceleration. While those with a positive eGFR(diff) had a lower risk.
A wearable-based aging clock associates with disease and behavior
Aging biomarkers play a vital role in understanding longevity, with the potential to improve clinical decisions and interventions. Existing aging clocks typically use blood, vitals, or imaging collected in a clinical setting. Wearables, in contrast, can make frequent and inexpensive measurements throughout daily living. Here we develop PpgAge, an aging clock using photoplethysmography at the wrist from a consumer wearable. Using the Apple Heart & Movement Study (n = 213,593 participants; >149...
Predictive gene expression signatures for Alzheimer's disease using post-mortem brain tissue
CONCLUSION: Molecular signatures underlying regional vulnerability to AD provide a framework for understanding genetic and systemic factors in disease progression. Findings highlight specific molecular pathways, including ECM-related processes and hormonal regulation, as key drivers of susceptibility. Finally, identified drug repurposing candidates present promising therapeutic avenues for further investigation.