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“Declaration of Dissent” denounces partisan messaging, rollback of environmental regulations, and dismantling of science office, among other concerns

USDA research points to viruses spread by pesticide-resistant mites, indicating a worrying trend

CONCLUSION: HD-tDCS could be a useful complementary treatment for improving sleep and movement in PD-pRBD patients.

CONCLUSION: The association between the TG/HDL-C ratio (atherogenic index) and incident ASCVD steadily attenuates with age. In adults over 65, an elevated ratio may be associated with a lower risk of incident ASCVD. These findings may reflect changes in metabolic atherosclerotic risk or a survival effect associated with aging and require further investigation.

Cognitive decline associated with healthy ageing is multifactorial: brain-based and lifestyle factors uniquely and jointly contribute to distinct neurocognitive trajectories of ageing. To evaluate existing models of neurocognitive ageing such as compensation, maintenance, or reserve, we explore how various known brain-based and cardiorespiratory fitness factors intersect to better understand cognitive decline. In a pre-registered study (https://osf.io/6fqg7), we tested 73 healthy older adults...

The rhesus macaque presents a promising model for translational research into human brain aging due to this species' long lifespan and close phylogenic relationship. We conducted a cross-sectional study identifying microstructural and morphological biomarkers of aging in a cohort of 37 healthy animals (18F/19M, aged 5-28 years), using high-resolution T2-weighted (T2w) and diffusion-weighted (DW) images. Using Tensor Based Morphometry, significant age-associated regional brain atrophy was...

Metformin is the most commonly prescribed glucose-lowering agent worldwide for the treatment of type II diabetes. Due to evidence of improvements in healthspan and lifespan in model organisms, and mechanistic data relevant to the hallmarks of aging, it has been considered a promising candidate in the search for pharmacological interventions that may attenuate the ageing process in humans. Various epidemiological studies have been influential in generating support for this hypothesis. These...

COVID-19 mortality disproportionately affects the elderly, yet the cellular and molecular factors contributing to age-related immune system remodeling remain unclear. Using SARS-CoV-derived ssRNA sequences, we modeled age-dependent immune responses in mice. Aged mice exhibited higher mortality and severe lung inflammation upon viral ssRNA challenge, mirroring clinical observations. We uncovered a pre-existing inflammatory state in aged mice, characterized by elevated baseline levels of specific...

Influenza poses a significant threat to older adults, exacerbated by age-related immune decline and the high prevalence of chronic conditions. Despite being the most effective preventive measure, influenza vaccination rates among this population remain alarmingly low, with Italy and Europe failing to meet the World Health Organization’s target of 75% coverage for individuals aged 65 and over. This review, informed by a geriatric conference in Enna, Sicily, examines the epidemiology of influenza...

Accurate diagnosis and precise estimation of disease progression states are crucial for developing effective treatment plans for patients with parkinsonism. Although various deep learning-based computer-aided diagnostic models have demonstrated benefits, they have been relatively underexplored in parkinsonism owing to limited data and lack of external validation. We introduce the hierarchical wavelet diffusion autoencoder (HWDAE), a generative self-supervised model trained with 1,934 dopamine...