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A kalihinol analog disrupts apicoplast function and vesicular trafficking in P. falciparum malaria
Science, Volume 385, Issue 6716, September 2024.
Mental programming of spatial sequences in working memory in the macaque frontal cortex
Science, Volume 385, Issue 6716, September 2024.
Cross-species single-cell spatial transcriptomic atlases of the cerebellar cortex
Science, Volume 385, Issue 6716, September 2024.
A host-adapted auxotrophic gut symbiont induces mucosal immunodeficiency
Science, Volume 385, Issue 6716, September 2024.
No sign of ghostly dark photons in afterglow of Big Bang
Subtle analysis of cosmological data probes novel concept of dark matter
Male bowerbirds build acoustics into their love shrines
Experiments suggest bowers amplify males’ songs and tweak their frequencies to woo females attending their show
The genetic secrets of the United States’s privately owned tigers
Big cats that formerly lived in roadside zoos show surprising diversity—but may not be able to help wild populations
Temperature-dependent lifespan extension is achieved in miR-80-deleted Caenorhabditis elegans by NLP-45 to modulate endoplasmic reticulum unfolded protein responses
MicroRNA plays a crucial role in post-transcriptional gene regulation and has recently emerged as a factor linked to aging, but the underlying regulatory mechanisms remain incompletely understood. In this study, we observed lifespan-extending effects in miR-80-deficient Caenorhabditis elegans at 20°C but not 25°C. At 20°C, miR-80 deletion leads to NLP-45 upregulation, which positively correlates to increased abu transcripts and extended lifespan. Supportively, we identified miR-80 binding...
Tissue-specific functions of MSCs are linked to homeostatic muscle maintenance and alter with aging
Mesenchymal stromal cells (MSCs), also known as fibro-adipogenic progenitors, play a critical role in muscle maintenance and sarcopenia development. Although analogous MSCs are present in various tissues, recent single-cell RNA-seq studies have revealed the inter-tissue heterogeneity of MSCs. However, the functional significance of MSC heterogeneity and its role in aging remain unclear. Here, we investigated the properties of MSCs and their age-related changes in seven mouse tissues through...
Quality control of mitochondria involves lysosomes in multiple definitive ways
Mitochondria are crucial organelles in maintaining cellular homeostasis. They are involved in processes such as energy production, metabolism of lipids and glucose, and cell death regulation. Mitochondrial dysfunction can lead to various health issues such as aging, cancer, neurodegenerative diseases, and chronic liver diseases. While mitophagy is the main process for getting rid of excess or damaged mitochondria, there are additional mechanisms for preserving mitochondrial quality. One such...
The potential of flavonoids to mitigate cellular senescence in cardiovascular disease
Aging is one of the most significant factors affecting cardiovascular health, with cellular senescence being a central hallmark. Senescent cells (SCs) secrete a specific set of signaling molecules known as the senescence-associated secretory phenotype (SASP). The SASP has a remarkable impact on age-associated diseases, particularly cardiovascular diseases (CVD). Targeting SCs through anti-aging therapies represents a novel strategy to effectively retard senescence and attenuate disease...
miR-96-5p expression is sufficient to induce and maintain the senescent cell fate in the absence of stress
Senescence is a cell fate driven by different types of stress that results in exit from the cell cycle and expression of an inflammatory senescence-associated secretory phenotype (SASP). Here, we demonstrate that stable overexpression of miR-96-5p was sufficient to induce cellular senescence in the absence of genotoxic stress, inducing expression of certain markers of early senescence including SASP factors while repressing markers of deep senescence including LINE-1 and type 1 interferons....
The revolution in high-throughput proteomics and AI
The recent capability to measure thousands of plasma proteins from a tiny blood sample has provided a new dimension of expansive data that can advance our understanding of human health. For example, the company SomaLogic has developed the means to measure more than 10,000 proteins and Thermo Fisher's Olink assays over 5400 proteins from as little as 2 μl. When these rich data are integrated with other layers of information from large patient cohorts, such as the UK Biobank's genetic, health, and...
Modeling the progression of neuropsychiatric symptoms in Alzheimer's disease with PET-based Braak staging
In Alzheimer's disease (AD), neuropsychiatric symptoms (NPS) correlate with tau deposition in the brain. Here, we investigated the association of PET-based Braak stages with NPS and assessed whether they predict annual changes in NPS. We evaluated 231 individuals in the aging and AD continuum. Participants were assigned a Braak stage at baseline and followed for 1.97 (s.d. 0.62) years. NPS were investigated using the Mild Behavioral Impairment Checklist (MBI-C) and the Neuropsychiatric Inventory...
Recovering single-cell expression profiles from spatial transcriptomics with scResolve
Many popular spatial transcriptomics techniques lack single-cell resolution. Instead, these methods measure the collective gene expression for each location from a mixture of cells, potentially containing multiple cell types. Here, we developed scResolve, a method for recovering single-cell expression profiles from spatial transcriptomics measurements at multi-cellular resolution. scResolve accurately restores expression profiles of individual cells at their locations, which is unattainable with...
Aging impaired locomotor and biochemical activities in Drosophila melanogaster Oregon R (fruit fly) model
Despite advancements in healthcare and increased lifespan, aging populations face numerous challenges, including declining cognitive function, increased susceptibility to chronic diseases, and reduced quality of life. This study investigated Aging impaired Locomotors and Biochemical Activities in Drosophila melanogaster Oregon R (Fruit Fly) Model with the aim to elucidate the mechanism involved. Adult wild-type Drosophila melanogaster Oregon R was used for this study. Survival assay, antioxidant...
The mitochondrial function of peripheral blood mononuclear cells in frail older patients
CONCLUSION: Mitochondrial dysfunctions (decreased mtDNAcn, impaired mitochondrial morphology, imbalanced mitochondrial dynamic, impaired mitochondrial respiratory function, and increased ROS levels) were significantly correlated with frail status.
Structural features within the NORAD long noncoding RNA underlie efficient repression of Pumilio activity
Long noncoding RNAs (lncRNAs) are increasingly appreciated for their important functions in mammalian cells. However, how their functional capacities are encoded in their sequences and manifested in their structures remains largely unknown. Some lncRNAs bind to and modulate the availability of RNA-binding proteins, but the structural principles that underlie this mode of regulation are unknown. The NORAD lncRNA is a known decoy for Pumilio proteins, which modulate the translation and stability...
The practical longevity of stockpiled A(H5N1) influenza vaccine
No abstract
Author Correction: The role of the haematopoietic stem cell niche in development and ageing
No abstract