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Optimization of adeno-associated viral (AAV) gene therapies vectors for balancing efficacy, longevity and safety for clinical application
Adeno-associated viral (AAV) vectors are an ideal platform for gene therapy due to their ability to deliver therapeutic cargos safely and effectively across various target organs. Their low immunogenicity contributes to long-lasting therapeutic effects. However, recent insights highlight the significance of CpG content within AAV vectors, where unmethylated CpG dinucleotides can trigger a TLR9-mediated immune response, leading to the rapid elimination of transduced cells. Clinical evidence...
Osteoporosis risk and its association with all-cause and cause-specific mortality among the elderly: a 16-year nationwide cohort study
CONCLUSIONS: The risk of osteoporosis is independently associated with the prediction of mortality. The OSTA may serve as a suitable predictor for mortality related to osteoporosis among the Asian population.
Impact of physical activity on the depression and self-care ability among Chinese older adults during the COVID-19 pandemic: propensity score matching analysis
CONCLUSION: Moderate and light physical activity in older adults alleviates depression and improves instrumental activities of daily living (IADLs), and light physical activity improves the level of activities of daily living (ADLs).
Daily briefing: Pregnancy’s true toll on the body
Showing ‘ability’ in ‘disability’ — how I mastered interviews while using a wheelchair
Trump’s bid for Greenland threatens to destabilize Arctic research
How Trump is following Project 2025’s radical roadmap to defund science
75% of US scientists who answered <i>Nature</i> poll consider leaving
‘Open source’ AI isn’t truly open — here’s how researchers can reclaim the term
AlphaFold is running out of data — so drug firms are building their own version
Confusion and worry as DOGE cuts hit NASA
Terminated grants include efforts to get students and underrepresented groups involved in science
Funds for global vaccine group axed, vaccine-autism study planned: Trump Tracker
Follow President Donald Trump’s impact on U.S. research and science globally
Trump plan for overhauling health agencies will cut 10,000 positions
NIH takes smaller hit than some other parts of HHS
In Science Journals
Science, Volume 387, Issue 6741, Page 1367-1369, March 2025.
Guiding science in China
Science, Volume 387, Issue 6741, Page 1356-1358, March 2025.
AAAS names 2024 Fellows
Science, Volume 387, Issue 6741, Page 1363-1366, March 2025.
In the ashes
Science, Volume 387, Issue 6741, Page 1343-1346, March 2025.
How did cow flu start? Scientists still don’t know
Science, Volume 387, Issue 6741, Page 1342-1342, March 2025.
South Africa caught in new tsunami of NIH grant cuts
Science, Volume 387, Issue 6741, Page 1341-1341, March 2025.
In Mexico, a whale of a controversy over gas port
Science, Volume 387, Issue 6741, Page 1340-1341, March 2025.