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A Frailty-Based Plasma Proteomic Signature Capturing Overall Health and Well-Being in Older Adults
Frailty is an age-related syndrome characterized by an increased vulnerability to adverse health outcomes in the face of stressors. By deriving a blood-based proteomic signature for frailty, the current study aimed to enhance the understanding of frailty biology and created a person-specific predictor for the risk of frailty and other adverse age-related health outcomes. A 25-protein signature (proteomic frailty index [pFI]) predictive of the cumulative frailty index (FI) in the LonGenity cohort...
Local Growth Hormone Facilitates Aging of the Colon Epithelial Microenvironment
Aging is associated with the appearance of senescent cells secreting the senescence-associated secretome, facilitating a milieu favoring age-related microenvironmental changes. As we previously showed the production of local nonpituitary growth hormone (npGH) in senescent colon epithelial cells, we now elucidate mechanisms underlying npGH action in the nontumorous colon tissue microenvironment. We demonstrate autocrine npGH action in normal human colon cells (hNCC) infected with...
Social and Activity Participation and Subjective Well-Being Among Older Adults in Japan: A Comparative Analysis of Healthy and Care-Needing Groups
Objectives: This study explores the relationship between social and activity participation (SAP) and subjective well-being (SWB) among older adults in Japan, with a particular focus on differences by care-needing status. Methods: Data were drawn from the 2019 Sakai City Older Adults Survey, including 5469 healthy and 406 care-needing individuals aged 65 and over (65.59% female). An ordered probit model was used to estimate the association between SAP and SWB, which was measured on an 11-point...
Younger adult brain utilizes interhemispheric strategy via ipsilateral dorsal premotor cortex for fine control of dexterous finger movements, unlike the aging brain
CONCLUSION: Our findings indicate that ipsilateral sensorimotor activity during the current dexterous task reflects different physiological mechanisms between younger and older adults. When performing the task, younger adults recruited the ipsilateral PMd, S1, and Area 2 by disinhibiting their interhemispheric inhibition to complement for their clumsiness; the ipsilateral PMd appeared important for the interhemispheric interaction, whereas the ipsilateral sensorimotor activity in older adults...
E2f1 Overexpression Reduces Aging-Associated DNA Damage in Cultured Cerebral Endothelial Cells and Improves Cognitive Performance in Aged Mice
As we age, cerebral endothelial cells (CECs) are less efficient in maintaining genome integrity and accumulate DNA damage. DNA damage in the brain endothelium can lead to the impairment of the blood-brain barrier (BBB), which is a major factor in brain dysfunction and dementia. Thus, identifying factors that regulate DNA repair in the brain endothelium can prevent brain dysfunction associated with aging. E2F1 is a transcription factor that regulates the expression of genes associated with DNA...