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Combined Exercise and Ursolic Acid Improve Hippocampal Neuronal Markers and Exploratory-Locomotor Behavior in Aged Diabetic Rats

2 months ago
Background: Diabetes mellitus is linked to progressive cognitive decline and motor impairments, especially among the aging population, highlighting the importance of early detection through reliable neuronal biomarkers. Proteins such as neurofilament light chain (NFL), neurogranin (Ng), and visinin-like protein 1 (VILIP-1) have emerged as indicators of neurodegeneration and associated behavioral changes. This study examined the effects of combined endurance and resistance exercise, along with...
Safoura Alizade

Overactivation of the inward rectifier K(+) channel 2.1 modulates intrinsic excitability of adult-born granule cells in the male Alzheimer's APP/PS1 mouse model

2 months ago
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive dysfunction, with spatial memory impairments among the earliest detectable deficits. The dentate gyrus (DG), a critical region for spatial discrimination, exhibits functional alterations in patients with AD. Adult-born granule cells (abGCs) with higher intrinsic excitability are involved in DG-dependent spatial memory. However, it remains unclear the changes in intrinsic excitability of abGCs and...
Yang Yang

AI-driven fusion of multimodal data for Alzheimer's disease biomarker assessment

2 months ago
Alzheimer's disease (AD) diagnosis hinges on detecting amyloid beta (Aβ) plaques and neurofibrillary tau (τ) tangles, typically assessed using PET imaging. While accurate, these modalities are expensive and not widely accessible, limiting their utility in routine clinical practice. Here, we present a multimodal computational framework that integrates data from seven distinct cohorts comprising 12, 185 participants to estimate individual PET profiles using more readily available neurological...
Varuna H Jasodanand

Preferred Settings of Care and Preferred Type of Home Care Among Heterosexual and Sexual Minority Individuals

2 months ago
CONCLUSIONS AND IMPLICATIONS: Regardless of sexual orientation, receiving care at home was the most preferred option, followed by moving to an assisted living facility. In terms of the type of home care, professional home care and a mix of formal and informal care were the most preferred options. Surprisingly, informal care was preferred by only 53.3% of people. Our results revealed that preferences for care settings (eg, own home, nursing home) and preferences for type of care (eg, informal...
Elżbieta Buczak-Stec

Physical Fitness, Biological Aging, and Healthy Longevity

2 months ago
CONCLUSIONS AND IMPLICATIONS: Enhanced CRF and muscle strength could offset the risk of premature health span termination associated with accelerated biological aging. Our findings suggest that biological aging rates should be considered in personalized fitness interventions to optimize health span. Public health strategies should prioritize cardiorespiratory and muscular fitness to mitigate aging-related health risks.
Ziyuan Chen