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International PhD students make emergency plans in fear of US immigration raids
Neck deep in overdiagnosis: Books in brief
Tariffs hit science labs: Trump’s levies raise cost of supplies
Trump team removes senior NIH chiefs in shock move
Revealed: where rare and giant starfish hide from an enigmatic killer
Author Correction: Record sea surface temperature jump in 2023–2024 unlikely but not unexpected
Author Correction: Traversable wormhole dynamics on a quantum processor
Integrating multiple evidence streams to understand insect biodiversity change
Science, Volume 388, Issue 6742, April 2025.
Human high-order thalamic nuclei gate conscious perception through the thalamofrontal loop
Science, Volume 388, Issue 6742, April 2025.
A geological timescale for bacterial evolution and oxygen adaptation
Science, Volume 388, Issue 6742, April 2025.
Osteoarthritis treatment via the GLP-1–mediated gut-joint axis targets intestinal FXR signaling
Science, Volume 388, Issue 6742, April 2025.
Homogeneous-heterogeneous bifunctionality in Pd-catalyzed vinyl acetate synthesis
Science, Volume 388, Issue 6742, April 2025.
Exogenous RNA surveillance by proton-sensing TRIM25
Science, Volume 388, Issue 6742, April 2025.
Nonlinear sound-sheet microscopy: Imaging opaque organs at the capillary and cellular scale
Science, Volume 388, Issue 6742, April 2025.
Indirect cost surprise, more NIH lawsuits, Kennedy’s mistakes: Trump Tracker
Follow President Donald Trump’s impact on U.S. research and science globally
This tiny, newborn caterpillar buzzes to defend its territory
The 2-millimeter-long bug is among the smallest animals ever observed performing territorial displays
Trump administration quashes NIH scientific integrity policy
The now-rescinded policy, designed to protect government researchers from political pressure, strongly endorsed DEI in science
Conserved components of the macroautophagy machinery in Caenorhabditis elegans
Macroautophagy involves the sequestration of cytoplasmic contents in a double-membrane autophagosome and its subsequent delivery to lysosomes for degradation and recycling. In Caenorhabditis elegans, autophagy participates in diverse processes such as stress resistance, cell fate specification, tissue remodeling, aging, and adaptive immunity. Genetic screens in C. elegans have identified a set of metazoan-specific autophagy genes that form the basis for our molecular understanding of steps...
Genome-wide CRISPR screen identifies BUB1 kinase as a druggable vulnerability in malignant pleural mesothelioma
Malignant pleural mesothelioma (MPM) is a rare yet highly aggressive malignancy with a severe prognosis. Compounded by the lack of effective treatment modalities, MPM remains a formidable health challenge. Therefore, the identification of actionable liabilities is critical for advancing precision medicine to combat this lethal disease. Here, we exploit an unbiased genome-wide CRISPR screen, integrating and cross-comparing three MPM cell lines with nonmalignant mesothelial cells, to selectively...
Nanopore sensing of protein and peptide conformation for point-of-care applications
The global population's aging and growth will likely result in an increase in chronic aging-related diseases. Early diagnosis could improve the medical care and quality of life. Many diseases are linked to misfolding or conformational changes in biomarker peptides and proteins, which affect their function and binding properties. Current clinical methods struggle to detect and quantify these changes. Therefore, there is a need for sensitive conformational sensors that can detect low-concentration...