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2 months 1 week ago
Science, Volume 389, Issue 6760, Page 611-612, August 2025.
Corinne Simonti, and Jesse Smith, Sacha Vignieri, L. Bryan Ray, Priscilla N. Kelly, Brad Wible, Peter Stern, Jack Huang, and Jesse Smith

Imaging collective quantum fluctuations of the structure of a complex molecule

2 months 1 week ago
Science, Volume 389, Issue 6760, Page 650-654, August 2025.
Benoît Richard, Rebecca Boll, Sourav Banerjee, Julia M. Schäfer, Zoltan Jurek, Gregor Kastirke, Kilian Fehre, Markus S. Schöffler, Nils Anders, Thomas M. Baumann, Sebastian Eckart, Benjamin Erk, Alberto De Fanis, Reinhard Dörner, Sven Grundmann, Patrik…

Insulin signaling in microglia: A metabolic switch controlling neuroinflammation and amyloid pathology in Alzheimer's disease

2 months 1 week ago
Insulin resistance is a risk factor for Alzheimer's disease (AD). Chen et al.¹ show that microglial insulin signaling is essential for metabolic homeostasis and immune regulation, while insulin resistance impairs Aβ clearance and promotes neuroinflammation in AD. Their findings reframe AD pathogenesis through a cell-type-specific lens.
Eugenio Barone