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Assessing sex as a biological variable is critical to determining the influence of environmental and lifestyle risks and protective factors mediating behavior and neuroplasticity across the lifespan. We investigated sex differences in affective behavior, memory, and hippocampal neurogenesis following short- or long-term exposure to exercise or chronic mild stress in young and aged mice. Male and female mice were assigned control, running, or chronic stress rearing conditions for 1 month (young)...

CONCLUSION: Years of education are longitudinally associated with the diet of older adults in the slow cognitive decline group. Food diversity partially mediates the relationship between years of education and cognitive trajectories. Interventions targeting education and dietary behaviors may help alleviate cognitive decline in older adults.

Cognitive impairment, marked by a decline in essential mental aspects such as attention, memory, and problem-solving, is significantly correlated with advancing age. This condition presents a major challenge for the elderly, adversely affecting quality of life, diminishing independence, and imposing substantial burdens on healthcare systems. Recent research indicates that vitamin K2 may be vital for preserving brain health and cognitive function. Traditionally recognized primarily for its role...

Science, Volume 387, Issue 6733, January 2025.

Science, Volume 387, Issue 6733, January 2025.

Science, Volume 387, Issue 6733, Page 484-486, January 2025.

Science, Volume 387, Issue 6733, Page 468-472, January 2025.

Science, Volume 387, Issue 6733, Page 454-454, January 2025.

Science, Volume 387, Issue 6733, Page 463-463, January 2025.

Science, Volume 387, Issue 6733, Page 462-462, January 2025.