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Economic collapse in Palestinian territories has led to illegal digs at prominent Bronze Age site, new study finds

Williams College says NSF and NIH requirement related to discrimination “undermines” academic freedom

Scientists film nematodes forming a superorganism in the wild for the first time

Data from the All of Us program confirm what many geneticists have long promoted

Fatigue is a nonmotor symptom that negatively affects Parkinson's disease (PD) patients' quality of life. The study of fatigue is complex and the brain functional neural underpinnings of fatigue in PD are yet to be clarified. The aim of this study was to investigate the functional connectivity (FC) of the fatigue brain network in PD-related fatigue symptomatology. Forty-nine PD patients, divided into PD patients with fatigue (PD-f) and PD patients with no fatigue (PD-nf), and 33 healthy controls...

One of the major factors inducing senescence is reactive oxygen species (ROS) produced from dysfunctional mitochondria. Therapeutic strategies that reduce mitochondrial ROS generation are considered essential for rejuvenating senescence, but effective methods have not yet been established. Here, we screened phenylpropanoids (PPs), secondary metabolites produced in response to oxidative stress in plants, and identified dehydroacteoside as a potential candidate. Dehydroacteoside restored...

Satellite cells are muscle-resident stem cells that maintain and repair muscle. Increasing evidence supports the contributing role of satellite cells in Duchenne muscular dystrophy (DMD), a lethal degenerative muscle disease caused by loss of dystrophin. However, whether or not satellite cells exhibit dysfunction due to loss of dystrophin remains unresolved. Here, we used single-cell RNA-sequencing (scRNA-seq) to determine how dystrophin deficiency impacts the satellite cell transcriptome and...

Cortical function, including sensory processing, is surprisingly resilient to neuron loss during aging and neurodegeneration. In this Article, we used the mouse auditory cortex to investigate how homeostatic mechanisms protect the representational map of sounds after neuron loss. We combined two-photon calcium imaging with targeted microablation of 30-40 sound-responsive neurons in layer 2/3. Microablation led to a temporary disturbance of the representational map, but it recovered in the...

CONCLUSIONS: By merging national data and distinguishing emotional from social loneliness, this study offers insights into their differential impacts on healthcare utilization among older adults in Taiwan. It emphasizes the importance of addressing loneliness to improve physical and mental well-being and optimize the effective utilization of healthcare resources.

Advancements in human induced pluripotent stem cell (hiPSC) technology have enabled co-culture models for disease modeling in physiologically relevant systems. However, co-culturing protocols face challenges in usability and consistency. Here, we introduce a robust, reproducible hiPSC-derived co-culture system integrating astrocytes, neurons, and microglia. This model leverages cryopreserved cells, enabling co-cultures within 20 days post-thaw. Comparing monocultures and tricultures, we...

Low circulating taurine concentrations have been proposed as a driver of the aging process. We found that circulating taurine concentrations increased or remained unchanged with age in three geographically distinct human cohorts as well as in nonhuman primates and mice when measured longitudinally (repeatedly in the same population) or cross-sectionally (sampling distinct populations at various ages). Moreover, considerable variability was observed in associations between taurine and age-related...

The role of beta band activity in cortico-basal ganglia interactions during motor control has been studied extensively in resting-state and for simple movements, such as button pressing. However, little is known about how beta oscillations change and interact in more complex situations involving rapid changes of movement in various contexts. To close this knowledge gap, we combined magnetoencephalography (MEG) and local field potential recordings from the subthalamic nucleus (STN) in Parkinson's...