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A court ruling may temporarily ease funding problems, but for many projects the long term outlook remains uncertain

Controversial attorney will oversee vast health research and drug safety programs

Microbiologist Elisabeth Bik donates $200,000 to support training, travel

CONCLUSION: The findings suggest that functional impairments in SMC patients might be associated with disruptions in the global and regional topological organization of the brain's functional connectome, offering new and significant insights into the pathophysiological mechanisms underlying SMC.

CONCLUSIONS AND IMPLICATIONS: Although inpatient mortality is higher in active cancer patients, older adults with active cancer who survive until inpatient geriatric rehabilitation discharge achieve similar functional gains and rates of discharge to the community. Functional improvement is of prognostic value in active cancer patients.

CONCLUSIONS AND IMPLICATIONS: Our findings underscore the complex interplay among physical activity, physical functioning, age, and genetic risk on processing speed. The protective associations of higher PAEE levels and better physical functioning, especially in older APOE4 carriers, suggest that maintaining an active lifestyle and mobility may be crucial for individuals with a genetic predisposition to cognitive decline.

Aging strongly affects the peripheral nervous system (PNS), triggering alterations that vary depending on the innervated tissue. The most frequent alteration in peripheral nerve aging is reduced nerve fiber and glial density which can lead to abnormal nerve functionality. Interestingly, the activation of a destructive phenotype takes place in macrophages across the PNS while a reduced number of neuronal bodies is a unique feature of some enteric ganglia. Single cell/nucleus RNA-sequencing has...

Structural socioeconomic inequality -the aggregate level unequal distribution of resources and opportunities within a region- significantly impacts brain health. Unlike traditional neuroscience approaches that focus on individual factors, recent studies highlight the biological embedding of macrosocial inequalities. We discuss studies on structural inequality that use EEG and f/MRI across diverse populations. Greater structural inequality is associated with adverse brain outcomes, such as...

Fullerene derivatives are widely employed as efficient electron-transporting layers (ETLs) in p-i-n perovskite photovoltaics but face challenges in mitigating interfacial recombination losses and ensuring stable film morphology. Non-fullerene acceptors (NFAs), commonly utilized in organic photovoltaics, present a promising alternative to fullerene-based ETLs. Nevertheless, the suboptimal performance of NFA-based devices underscores the need for molecular engineering to tailor their properties....

Exercise can improve health via skeletal muscle remodeling. Elucidating the underlying mechanism may lead to new therapeutics for aging-related loss of skeletal muscle mass. Here, we show that endurance exercise suppresses expression of YT521-B homology domain family (Ythdf1) in skeletal muscle, which recognizes the N6-methyladenosine (m6A). Ythdf1 deletion phenocopies endurance exercise-induced muscle hypertrophy in mice increases muscle mitochondria content and type I fiber specification. At...

Intervertebral disc degeneration (IVDD) is a leading cause of low back pain, with limited effective treatments due to an incomplete understanding of disease mechanisms. In this study, we report that circFUNDC1, a nuclear circular RNA, is markedly downregulated in nucleus pulposus cells (NPCs) from patients with end-stage IVDD. CircFUNDC1 is derived from the gene encoding the FUN14 domain-containing 1 (FUNDC1) protein, which is essential for mitophagy and cell survival. Functional analyses reveal...

Cellular senescence is a stable cell cycle arrest that occurs in response to various stress stimuli and affects multiple cell types, including endothelial cells (ECs). Senescent cells accumulate with age, and their removal has been linked to reduced age-related diseases. However, some senescent cells are important for tissue homeostasis. Therefore, understanding the diversity of senescent cells in a cell-type-specific manner and their underlying molecular mechanisms is essential. Senescence...

The main aim of this study is to explore the relationship between the elderly population and economic growth in 25 North and South American countries use annual secondary data from 1961 to 2021. Instead of focusing on the conditional mean, this study tests for Granger causality in the entire conditional distribution of the elderly population and economic growth through wavelet coherence analysis. The study findings indicated a unidirectional Granger causality running from per capita gross...

Fraud undermines Alzheimer's disease research.

The future deployment of terawatt-scale proton exchange membrane water electrolyzer (PEMWE) technology necessitates development of an efficient oxygen evolution catalyst with low cost and long lifetime. Currently, the stability of the most active iridium (Ir) catalysts is impaired by dissolution, redeposition, detachment, and agglomeration of Ir species. Here we present a ripening-induced embedding strategy that securely embeds the Ir catalyst in a cerium oxide support. Cryogenic electron...

Invertebrate models have been instrumental in advancing our understanding of the molecular mechanisms of ageing. The isolation of single gene mutations that both extend lifespan and improve age-related health have identified potential targets for therapeutic intervention to alleviate age-related morbidity. Here, we find that genetic loss of function of the G protein-coupled metabotropic glutamate receptor (DmGluRA) in Drosophila extends the lifespan of female flies. This longevity phenotype was...

The aging brain experiences a significant decline in proteasome function. The proteasome is critical for many key neuronal functions including neuronal plasticity, and memory formation/retention. Treatment with proteasome inhibitors impairs these processes. Our study reveals a marked reduction in 20S and 26S proteasome activities in aged mice brains, including in the hippocampus, this is driven by reduced functionality of aged proteasome. The decline in proteasome activity is matched by a...

As global life expectancy increases, the focus has shifted from merely extending lifespan to promoting healthy aging. GSTA1, GSTA2, and GSTA3 (GSTA1-3), members of the alpha class of glutathione S-transferases, are involved in diverse biological processes, including metabolism and immune regulation, highlighting their potential influence on human health span and lifespan. In this study, we employed Caenorhabditis elegans as a model organism to investigate the role of gst-35, an ortholog of...

CONCLUSIONS: The Arabic short version of Icon-FES is a reliable and valid tool for assessing concern about falling among community-dwelling older adults. It offers an innovative approach through culturally adapted visual elements that could enhance applicability, enabling accurate assessment and supporting targeted interventions among Arabic-speaking older adults.

Age-associated thymic involution leads to a significant decline in thymic T cell output, a major contributor to immunosenescence in the elderly. Accurately measuring thymic output is therefore critical for understanding the mechanisms behind immune aging. Furthermore, robust quantification of thymic output is essential in various other clinical and research settings, including the diagnosis of immunodeficiencies and the monitoring of T cell reconstitution following therapeutic interventions like...