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Age-Related Alterations in Hippocampal Microstructure Quantified Using High-Gradient Diffusion MRI (dMRI) in an Unfolded Hippocampal Space

2 months 1 week ago
The hippocampus, a brain region critical for memory, undergoes significant age-related changes at both the macroscopic and microstructural levels. This study investigates these changes using high-gradient diffusion MRI (dMRI) data analyzed in an unfolded hippocampal space. We applied the Soma and Neurite Density Imaging (SANDI) model to quantify microstructural alterations in 72 cognitively healthy participants aged 19-85 years, scanned on a 3 T Connectome MRI scanner with a maximum gradient...
Yixin Ma

In Science Journals

2 months 1 week ago
Science, Volume 390, Issue 6773, Page 586-588, November 2025.
Michael Funk, and Rachel Wood, Jake S. Yeston, Jesse Smith, Ian S. Osborne, Jelena Stajic, Angela Hessler, Christiana N. Fogg, Dorothy Hallberg, Madeleine Seale, Di Jiang, Yevgeniya Nusinovich, Sarah H. Ross, Stella M. Hurtley, Phil Szuromi, Marc S…