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Toll-like receptor 5 (TLR5) plays a critical role beyond its traditional function in innate immunity, significantly impacting metabolic regulation and liver health. Previously, we reported that TLR5 activation extends the healthspan and lifespan of aging mice. This study demonstrates that TLR5 deficiency leads to pronounced metabolic abnormalities with age, primarily affecting liver metabolic functions rather than intestinal inflammation. Comprehensive RNA sequencing analysis revealed that TLR5...

Introduction: High-intensity interval training (HIIT) is a form of interval exercise that enhances capacity and benefits well-being. Resveratrol is a naturally occurring polyphenol prevalent in grapes and red wine, demonstrating significant health effects on the body. This study sought to evaluate the synergistic effects of swimming HIIT and resveratrol intake on the expression of SIRTs 4, SIRTs 5, and superoxide dismutases (SOD1 and SOD2) in the frontal lobe of elderly rats. Materials and...

Researchers seek common patterns in adolescence, in chimps, elephants, and dolphins

Geographers estimate animal geoengineers have an impact equivalent to 200 monsoon seasons

This study investigates the differences in multimodal physiological signals between patients with Parkinson's disease (PD) and healthy individuals, focusing on how symptom fluctuations affect these signals in PD. A total of 35 PD patients and 30 healthy controls participated. The PD patients were further categorized into two groups: those with symptom fluctuations (SF) and those without (NSF). Multimodal physiological signals, including EEG, ECG, respiration, and pulse, were recorded in resting...

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The aim of the present study was to examine the relative impact of the various sensory feedback sources on the improvement of postural control following nGVS in older adults. Thirty-eight participants (20 controls; 18 older adults) were recruited for this study. Participants performed the modified clinical test of sensory integration as part of the postural control assessment. Older adults received an nGVS stimulation which was compared to their baseline measurements and to an optimal...

The chromosome 5p15.33 region, which encodes telomerase reverse transcriptase (TERT), harbors multiple germline variants identified by genome-wide association studies (GWAS) as risk for some cancers but protective for others. Here, we characterize a variable number tandem repeat within TERT intron 6, VNTR6-1 (38-bp repeat unit), and detect a strong link between VNTR6-1 alleles (Short: 24-27 repeats, Long: 40.5-66.5 repeats) and GWAS signals rs2242652 and rs10069690 within TERT intron 4....