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SP140–RESIST pathway regulates interferon mRNA stability and antiviral immunity
Quantum physicists unveil most ‘trustworthy’ random-number generator yet
How the brain separates real images from those it imagines
Meet the MIT engineer who invented an AI-powered way to restore art
This stretchy neural implant grows with an axolotl’s brain
Using RNA therapeutics to promote healthy aging
To progress, science must be truly global
Digging foxholes in the dark
How to keep weight off after obesity drugs
Major telescope hosts world’s largest digital camera: how it will transform astronomy
NIH chief stands by funding cuts to ‘politicized science’ at tense hearing
U.K. science funding to remain flat for next 4 years
Government also announces cash for nuclear, carbon capture, and AI projects
A near-real-time data-assimilative model of the solar corona
Science, Volume 388, Issue 6753, Page 1306-1310, June 2025.
Neuroprotective and cognitive benefits of Semaglutide: Insights into the underlying molecular mechanisms
Neuronal injury is a common complication in patients with diabetes. These injuries include a wide range of neurobehavioral complications that significantly reduce the neuronal network efficiency and quality of life in affected individuals. Currently, diabetes-induced neuronal complications are a major global health challenge, and many studies have been performed to prevent or slow their progression. Semaglutide is a novel form of glucagon-like peptide-1 (GLP-1) agonist agents that has recently...
Dementia is deadly - the UN needs to take it more seriously
No abstract
Unraveling Alzheimer's complexity with a distinct Abeta(42) fibril type and specific AV-45 binding
Abnormal aggregation of amyloid-β protein (1-42) (Aβ(42)) is the primary pathology in Alzheimer's disease (AD). Two types of Aβ(42) fibrils have been identified in the insoluble fraction of diseased human brains. Here, we report that the fraction previously deemed 'soluble' during sarkosyl extraction of AD brains actually harbors numerous amyloid fibrils, with a looser bundling than those in the insoluble fraction. Using cryo-electron microscopy (cryo-EM), we discover a third type (type III) of...
Daily briefing: The energy-drink ingredient taurine doesn't seem to boost lifespan after all
No abstract
Recurrent somatic mutation and progerin expression in early vascular aging of chronic kidney disease
Early vascular aging plays a central role in chronic kidney disease (CKD), but its molecular causes remain unclear. Somatic mutations accumulate in various cells with age, yet their functional contribution to aging tissues is not well understood. Here we found progerin, the protein responsible for the premature aging disease Hutchinson-Gilford progeria syndrome, steadily recurring in vascular smooth muscle cells of patients with CKD. Notably, the most common progeria-causing mutation, LMNA...
Senescence-related proteins in blood predict aging traits
No abstract
Activity-dependent synapse elimination requires caspase-3 activation
During brain development, synapses are initially formed in excess and are later eliminated in an activity-dependent manner. Weak synapses are preferentially removed, but the mechanism linking neuronal activity to synapse removal is unclear. Here, we show that, in the developing mouse visual pathway, inhibiting synaptic transmission induces postsynaptic activation of caspase-3. Caspase-3 deficiency results in defects in synapse elimination driven by both spontaneous and experience-dependent...