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C4d, a high-affinity LilrB2 ligand, is elevated in Alzheimer's disease and mediates synapse pruning
Synapse pruning sculpts neural circuits throughout life. The human Leukocyte immunoglobulin-like receptor type B2 (LilrB2)/murine Paired immunoglobulin receptor B (PirB) receptors expressed in neurons and complement protein C4 have been separately implicated in pruning. Here, we report that C4d, a C4 cleavage product with unknown function, binds LilrB2/PirB with nanomolar affinity. C4d and LilrB2 colocalize at excitatory synapses in the human cerebral cortex as well as with beta amyloid in...
ZBP1 pathway promotes tumor immunogenicity in the combination of anti-HER2 therapy and epigenetic therapy
Z-form DNA (Z-DNA)-binding protein 1 (ZBP1)-mediated RNA sensing plays a critical role in tumor immunogenicity. However, how to augment ZBP1 signaling-mediated immunogenic tumor cell death to boost targeted therapy is yet unknown. Here, we demonstrated that epigenetic modulation by 5-aza-2'-deoxycytidine (5AZA) facilitated antitumor effects of anti-HER2 therapy, which requires antitumor CD8^(+) T cell responses initiated by ZBP1-mediated tumor immunogenicity. Moreover, the combination of...
Gut metagenome and plasma metabolome profiles in older adults suggest pyruvate metabolism as a link between sleep quality and frailty
Poor sleep quality is associated with increased frailty in older adults, but the role of the gut microbiome in this relationship remains unclear. Here, gut metagenome and plasma metabolome were profiled in 1,225 individuals aged 62-96 years. Poor sleep quality was associated with reduced abundances of potential probiotics such as Faecalibacterium prausnitzii and elevated abundances of pathobionts. A gut microbiome sleep quality index (GMSI) was developed to quantify microbial balance related to...
Negative wealth shock and epigenetic aging in middle-aged and older adults
CONCLUSIONS: Our study identifies a significant relationship between negative wealth shocks and biological aging in middle-aged and older adults. This suggests that socioeconomic factors, particularly sudden economic losses and fluctuations, should be considered in strategies for promoting healthy longevity and aging interventions. Additionally, there is a need for unemployment protection policies or measures to help stabilize medical and food consumption for households or individuals during...
USDA funding delays under Trump compromise agricultural research
Sharp drop in grant awards leaves researchers frustrated
Daily briefing: AI model can predict your risk of diseases years before you might get them
Tipsy bats and perfect pasta: Ig Nobels celebrate ‘improbable’ research
Soft robot steers itself down the human airway
Beware the drive to scale technology
Science, Volume 389, Issue 6766, September 2025.
Erratum for the Research Article “Differential absorption of circularly polarized light by a centrosymmetric crystal” by K. A. Parrish et al.
Science, Volume 389, Issue 6766, September 2025.
Erratum for the Research Article “Tropical forest clearance impacts biodiversity and function, whereas logging changes structure” by C. J. Marsh et al.
Science, Volume 389, Issue 6766, September 2025.
The contrast between monovalent and multivalent metal battery anodes
Science, Volume 389, Issue 6766, September 2025.
Genomic diversity of the African malaria vector Anopheles funestus
Science, Volume 389, Issue 6766, September 2025.
Kinetic organization of the genome revealed by ultraresolution multiscale live imaging
Science, Volume 389, Issue 6766, September 2025.
Genomic demography predicts community dynamics in a temperate montane forest
Science, Volume 389, Issue 6766, September 2025.
Functional maps of a genomic locus reveal confinement of an enhancer by its target gene
Science, Volume 389, Issue 6766, September 2025.
1206 genomes reveal origin and movement of Aedes aegypti driving increased dengue risk
Science, Volume 389, Issue 6766, September 2025.