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More flow upstream and less flow downstream: The changing form and function of global rivers
Science, Volume 386, Issue 6727, Page 1305-1311, December 2024.
Sun-like stars produce superflares roughly once per century
Science, Volume 386, Issue 6727, Page 1301-1305, December 2024.
Diverse phage communities are maintained stably on a clonal bacterial host
Science, Volume 386, Issue 6727, Page 1294-1300, December 2024.
A synthetic protein-level neural network in mammalian cells
Science, Volume 386, Issue 6727, Page 1243-1250, December 2024.
The two cultures meet again
Science, Volume 386, Issue 6727, Page 1218-1221, December 2024.
Structural basis of H3K36 trimethylation by SETD2 during chromatin transcription
Science, Volume 387, Issue 6733, Page 528-533, January 2025.
Confronting risks of mirror life
Science, Volume 386, Issue 6728, Page 1351-1353, December 2024.
Scientists in Latin America struggle to get key chemicals and other reagents for experiments. A group has begun to help
Several leaders of a multinational effort expanding access to essential lab materials discuss its impact and a major funding boost
Thousands of previously unknown mountains and hills spotted in best-yet seafloor map
Data from SWOT satellite could stimulate studies of plate tectonics
Leading scientists urge ban on developing ‘mirror-image’ bacteria
Looking-glass organisms would pose existential threat, they say. Others say restrictions are premature
Mystery woman’s DNA reveals close family ties between Europe’s earliest people
Pair of studies shines light on how modern humans and Neanderthals settled the continent together
<em>Science</em>’s 2024 Breakthrough of the Year: Opening the door to a new era of HIV prevention
A drug with a novel mechanism protects people against the AIDS virus for 6 months. It could speed the end of the epidemic—if those who need it most get access
News at a glance: Protecting monarch butterflies, mapping ocean life with DNA, and a radar satellite’s twin
The latest in science and policy
‘Blob’ heat wave killed millions of seabirds—and they haven’t bounced back
Historic 2016 event may have permanently altered northern Pacific ecosystem
‘Enigmatic’ cave art was made by ice age children
Charcoal doodling appears 14,000 years ago, as adults drew more proficiently nearby
"Current and emerging drug therapies in Alzheimer's disease: A pathophysiological Perspective"
The analytical and experimental investigation of several targets and biomarkers that help in explaining significant cognitive deficits, covering drug development and precision medicine aimed at different chronic neurodegenerative conditions such as Alzheimer's disease (AD), Parkinson's disease, synaptic dysfunction, brain damage from neuronal apoptosis, and other disease pathologies; this served as the foundation for all phase studies. The focus of current therapeutic approaches is on developing...
The complex relationship between gut microbiota and Alzheimer's disease: A systematic review
Alzheimer's disease (AD) is a progressive, degenerative disorder of the central nervous system. Despite extensive research conducted on this disorder, its precise pathogenesis remains unclear. In recent years, the microbiota-gut-brain axis has attracted considerable attention within the field of AD. The gut microbiota communicates bidirectionally with the central nervous system through the gut-brain axis, and alterations in its structure and function can influence the progression of AD....
Metabolic regulation in adult and aging skeletal muscle stem cells
Adult stem cells maintain homeostasis and enable regeneration of most tissues. Quiescence, proliferation, and differentiation of stem cells and their progenitors are tightly regulated processes governed by dynamic transcriptional, epigenetic, and metabolic programs. Previously thought to merely reflect a cell's energy state, metabolism is now recognized for its critical regulatory functions, controlling not only energy and biomass production but also the cell's transcriptome and epigenome. In...
Aging research from bench to bedside and beyond: What we learned from Sammy Basso
No abstract
Hypoxia increases methylated histones to prevent histone clipping and heterochromatin redistribution during Raf-induced senescence
Hypoxia enhances histone methylation by inhibiting oxygen- and α-ketoglutarate-dependent demethylases, resulting in increased methylated histones. This study reveals how hypoxia-induced methylation affects histone clipping and the reorganization of heterochromatin into senescence-associated heterochromatin foci (SAHF) during oncogene-induced senescence (OIS) in IMR90 human fibroblasts. Notably, using top-down proteomics, we discovered specific cleavage sites targeted by Cathepsin L (CTSL) in H3,...