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‘We are a target’: scientific society under pressure after Trump DEI crackdown
How my research focus exposed me to threats and harassment
From viral variants to devastating storms, how names shape the public's reaction to science
Bonobos know when you’re in the know ― and when you’re not
Scientists globally are racing to save vital health databases taken down amid Trump chaos
Poetry on Mars and robots on Earth: Books in brief
Nutrient-driven histone code determines exhausted CD8+ T cell fates
Science, Volume 387, Issue 6734, February 2025.
Kidney multiome-based genetic scorecard reveals convergent coding and regulatory variants
Science, Volume 387, Issue 6734, February 2025.
Supersaturation mutagenesis reveals adaptive rewiring of essential genes among malaria parasites
Science, Volume 387, Issue 6734, February 2025.
The essential genome of Plasmodium knowlesi reveals determinants of antimalarial susceptibility
Science, Volume 387, Issue 6734, February 2025.
Sequence-dependent activity and compartmentalization of foreign DNA in a eukaryotic nucleus
Science, Volume 387, Issue 6734, February 2025.
New journal co-founded by NIH nominee raises eyebrows, misinformation fears
The Journal of the Academy of Public Health claims to open up scientific communication. But its unusual editorial policies have some scientists concerned
How a cancer researcher lost a gender-related grant to Trump’s executive orders
“Unethical, unlawful, inhumane”: NIH-backed scientist decries termination of study collecting data on sexual orientation and gender identity of cancer patients
In Mexico, budget cuts dim hopes for a science funding revival
Research centers move to reduce salaries and lay off staff
‘Madness’: Trump freeze on global HIV prevention efforts sparks disbelief, anger
After chaotic halt, PEPFAR’s global distribution of HIV treatments may be resuming but limits on using drugs to curb viral spread remain
‘My boss was crying.’ NSF confronts potentially massive layoffs and budget cuts
Trump could propose slashing agency’s budget by two-thirds
After damage by scientists, Inuit group closes off access to Earth’s oldest rocks
Move by tribe in northern Canada could complicate efforts to study earliest moments on planet
Beyond amyloid plaque, targeting alpha-synuclein in Alzheimer disease: The battle continues
Alzheimer's disease (AD) is the most common neurodegenerative brain disease and represents the most frequent type of dementia characterized by cognitive impairment and amnesia. AD neuropathology is connected to the development of synaptic dysfunction and loss of synaptic homeostasis due to an imbalance in the production and clearance of β-amyloid (Aβ) and intracellular neurofibrillary tangles (NFTs). However, AD neuropathology is complex and may relate to the deposition of other misfolded...
Reclassification of the conventional risk assessment for aging-related diseases by electrocardiogram-enabled biological age
An artificial intelligence (AI)-enabled electrocardiogram (ECG) model has been developed in a healthy adult population to predict ECG biological age (ECG-BA). This ECG-BA exhibited a robust correlation with chronological age (CA) in healthy adults and additionally significantly enhanced the prediction of aging-related diseases' onset in adults with subclinical diseases. The model showed particularly strong predictive power for cardiovascular and non-cardiovascular diseases such as stroke,...
Differences in cholinergic terminal density in adults with Down syndrome compared to neurotypical controls measured by [<sup>18</sup>F]-fluoroethoxybenzovesamicol positron emission tomography imaging
Adults with Down syndrome are genetically predisposed to developing Alzheimer's disease after the age of 40. The cholinergic system, which is critical for cognitive functioning, is known to decline in Alzheimer's disease and although first investigated in individuals with Down syndrome 40 years ago, remains relatively understudied. Existing studies suggest individuals with Down syndrome have an intact cholinergic system at birth that declines through adulthood alongside the development of...