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Association between prescription drugs and all-cause mortality risk in the UK population
Although most drugs currently approved are meant to treat specific diseases or symptoms, it has been hypothesized that some might bear a beneficial effect on lifespan in healthy older individuals, outside of their specific disease indication. Such drugs include, among others, metformin, SGLT2 inhibitors and rapamycin. Since 2006, the UK biobank has recorded prescription medication and mortality data for over 500'000 participants, aged between 40 and 70 years old. In this work, we examined the...
Rejuvenation factor PF4: a potential gatekeeper for neurodegenerative diseases
Recently, it is discovered PF4 is a cognitive enhancer that improved the cognitive abilities of younger mice and gave older animals their middle-aged acuity back. PF4 works by reducing inflammation during the aging process. As we all known, aging is undoubtedly the main risk factor of neurodegenerative diseases. Furthermore, inflammation has been extensively investigated and attracted even more interest. Therefore, the aim of the proposal is to highlight the worth of PF4 in inflammaging of...
Daily briefing: Is this where mitochondria came from?
Mpox vaccine roll-out begins in Africa: what will success look like?
Believe it or not, this lush landscape is Antarctica
A spaceship punched an asteroid — we’re about to learn what came next
Sex dimorphism in the aged melanoma microenvironment
Digital reminders improve vaccination rates
World-first therapy using donor cells sends autoimmune diseases into remission
Why hasn’t deadly bird flu reached Australia yet?
Cancer immunotherapy by γδ T cells
Science, Volume 386, Issue 6717, October 2024.
Phage-triggered reverse transcription assembles a toxic repetitive gene from a noncoding RNA
Science, Volume 386, Issue 6717, October 2024.
De novo gene synthesis by an antiviral reverse transcriptase
Science, Volume 386, Issue 6717, October 2024.
Relocalizing transcriptional kinases to activate apoptosis
Science, Volume 386, Issue 6717, October 2024.
Nr5a2 is dispensable for zygotic genome activation but essential for morula development
Science, Volume 386, Issue 6717, October 2024.
Fermilab’s not-quite-new boss aims to end turmoil, boost performance
University of Chicago will again lead a group to manage the United States’s only dedicated particle physics lab
Racial bias can taint the academic tenure process—at one particular point
Black and Hispanic professors fare worse when voters include colleagues who are less familiar with their work, new study finds
‘Amazing’ method traces 18th century smokers—and finds English women puffed away
Novel technique analyzing metabolites of tobacco in bone could be applied to other substances, potentially revising views of past health and behavior
Long-term survival of Congo’s biodiversity threatened by lack of local scientists
Building a cadre of researchers is of “vital importance” to saving the world's second largest rainforest
‘Wall’ of oysters once filled Europe’s coast, historical map reveals
Records from past centuries show vast extent of bivalves before overharvesting, may inspire restoration