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Author Correction: Fetal hepatocytes protect the HSPC genome via fetuin-A
Vertical structure of an exoplanet’s atmospheric jet stream
Migraine is more than a headache — a radical rethink offers hope to one billion people
Molecular glue unexpectedly mimics the effect of cancer mutations
Why is it so hard to rewrite a genome?
Pinpointing neurons that hinder cancer treatment
Don’t overlook the mental-health costs of California’s wildfires
Charles Darwin saw the importance of development in evolution
A giant leap for machine translation could be even bigger
A sustainable ocean needs thriving ocean societies
Dogs, like people, may use blinking to bond
Pet dogs blink more in response to videos of other dogs blinking—new evidence of their complex communication
‘I really wanted something to happen.’ The students behind the Stand Up for Science protests
New group hopes to turn out researchers for 7 March demonstrations against Trump administration policies
Mass firings decimate U.S. science agencies
White House dismissals and rationale challenged by dismissed scientists and lawsuits
‘Eloquent’ mice point to protein that may have shaped human speech
Mice modified to have “human” version of a protein made more complex squeaks
Does drug repurposing bridge the gaps in management of Parkinson's disease? Unravelling the facts and fallacies
Repurposing the existing drugs for the management of both common and rare diseases is increasingly appealing due to challenges such as high attrition rates, the economy, and the slow pace of discovering new drugs. Drug repurposing involves the utilization of existing medications to treat diseases for which they were not originally intended. Despite encountering scientific and economic challenges, the pharmaceutical industry is intrigued by the potential to uncover new indications for...
Parkinson disease pathology can originate in the kidney
No abstract
Exploring morphological and microstructural signatures across the Alzheimer's spectrum and risk factors
Neural alterations, including myelin degeneration and inflammation-related iron burden, may accompany early Alzheimer's disease (AD) pathophysiology. This study aims to identify multi-modal signatures associated with MRI-derived atrophy and quantitative MRI (qMRI) measures of myelin and iron in a unique dataset of 158 participants across the AD spectrum, including those without cognitive impairment, at familial risk for AD, with mild cognitive impairment, and with AD dementia. Our results...
Cell enlargement modulated by GATA4 and YAP instructs the senescence-associated secretory phenotype
Dynamic changes in cell size are associated with development and pathological conditions, including aging. Although cell enlargement is a prominent morphological feature of cellular senescence, its functional implications are unknown; moreover, how senescent cells maintain their enlargement state is less understood. Here we show that an extensive remodeling of actin cytoskeleton is necessary for establishing senescence-associated cell enlargement and pro-inflammatory senescence-associated...
BMP signaling promotes zebrafish heart regeneration via alleviation of replication stress
In contrast to mammals, adult zebrafish achieve complete heart regeneration via proliferation of cardiomyocytes. Surprisingly, we found that regenerating cardiomyocytes experience DNA replication stress, which represents one reason for declining tissue regeneration during aging in mammals. Pharmacological inhibition of ATM and ATR kinases revealed that DNA damage response signaling is essential for zebrafish heart regeneration. Manipulation of Bone Morphogenetic Protein (BMP)-Smad signaling...
Studying aging in the wild can help us to understand resilience and healthy aging
No abstract