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Photocatalytic furan-to-pyrrole conversion
Science, Volume 386, Issue 6717, Page 99-105, October 2024.
A multivalent mRNA-LNP vaccine protects against Clostridioides difficile infection
Science, Volume 386, Issue 6717, Page 69-75, October 2024.
Environment-independent distribution of mutational effects emerges from microscopic epistasis
Science, Volume 386, Issue 6717, Page 87-92, October 2024.
The pace of life for forest trees
Science, Volume 386, Issue 6717, Page 92-98, October 2024.
The global loss of avian functional and phylogenetic diversity from anthropogenic extinctions
Science, Volume 386, Issue 6717, Page 55-60, October 2024.
Grain rotation mechanisms in nanocrystalline materials: Multiscale observations in Pt thin films
Science, Volume 386, Issue 6717, Page 49-54, October 2024.
Creation of de novo cryptic splicing for ALS and FTD precision medicine
Science, Volume 386, Issue 6717, Page 61-69, October 2024.
ENSO affects the North Atlantic Oscillation 1 year later
Science, Volume 386, Issue 6717, Page 82-86, October 2024.
Confronting division with wisdom
Science, Volume 386, Issue 6717, Page 33-33, October 2024.
The road to the Paris Agreement
Science, Volume 386, Issue 6717, Page 32-32, October 2024.
Asteroid impact may have turned ants into fungus farmers 66 million years ago
Cataclysm that killed dinosaurs and shook up life on Earth likely paved the way for this mutually beneficial relationship
News at a glance: A new schizophrenia drug, AI guardrails, and saving nearly extinct species
The latest in science and policy
To slow global warming, could methane be stripped from the air?
U.S. panel calls for boosting research into capturing potent greenhouse gas
Complete map of fruit fly brain circuitry unveiled
AI tools and hundreds of human proofreaders helped tease apart 140,000 neurons in a brain the size of a grain of sand
Dolphins grin at one another when they’re playing, study suggests
But questions remain about what the animals are actually communicating
Bridging brain insulin resistance to Alzheimer's pathogenesis
Emerging evidence links type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), with brain insulin resistance (BIR) as a key factor. In a recent study, Lanzillotta et al. reveal that reduced biliverdin reductase-A (BVR-A) impairs glycogen synthase kinase 3β (GSK3β) phosphorylation, causing mitochondrial dysfunction and exacerbating brain insulin resistance in the progression of both T2DM and AD.
The role of PINK1-Parkin in mitochondrial quality control
Mitophagy mediated by the recessive Parkinson's disease genes PINK1 and Parkin responds to mitochondrial damage to preserve mitochondrial function. In the pathway, PINK1 is the damage sensor, probing the integrity of the mitochondrial import pathway, and activating Parkin when import is blocked. Parkin is the effector, selectively marking damaged mitochondria with ubiquitin for mitophagy and other quality-control processes. This selective mitochondrial quality-control pathway may be especially...
Can flashing lights stall Alzheimer's? What the science shows
No abstract
How long COVID could lift the fog on neurocognitive disorders
No abstract
Midlife dynamics of white matter architecture in lexical production
We aimed to examine the white matter changes associated with lexical production difficulties, beginning in midlife with increased naming latencies. To delay lexical production decline, middle-aged adults may rely on domain-general and language-specific compensatory mechanisms proposed by the LARA model (Lexical Access and Retrieval in Aging). However, the white matter changes supporting these mechanisms remains largely unknown. Using data from the CAMCAN cohort, we employed an unsupervised and...