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Infrared nanosensors of piconewton to micronewton forces
Monoallelic expression can govern penetrance of inborn errors of immunity
Formation of individual stripes in a mixed-dimensional cold-atom Fermi–Hubbard system
Non-Abelian lattice gauge fields in photonic synthetic frequency dimensions
Brain-wide cell-type-specific transcriptomic signatures of healthy ageing in mice
A collicular map for touch-guided tongue control
High-resolution genomic history of early medieval Europe
FBP1 controls liver cancer evolution from senescent MASH hepatocytes
Upconverting microgauges reveal intraluminal force dynamics in vivo
Bone marrow niches orchestrate stem-cell hierarchy and immune tolerance
GaAs nano-ridge laser diodes fully fabricated in a 300-mm CMOS pilot line
Limitations of ice cores in reconstructing temperature seasonality
Science in 2025: what to expect this year
Reply to: Limitations of ice cores in reconstructing temperature seasonality
<cite>Science</cite> Visuals team picks its favorite stories of the year
Team members describe what went into making and publishing 2024’s most engaging images and multimedia
A machine learning approach identifies cellular senescence on transcriptome data of human cells in vitro
Although cellular senescence has been recognized as a hallmark of aging, it is challenging to detect senescence cells (SnCs) due to their high level of heterogeneity at the molecular level. Machine learning (ML) is likely an ideal approach to address this challenge because of its ability to recognize complex patterns that cannot be characterized by one or a few features, from high-dimensional data. To test this, we evaluated the performance of four ML algorithms including support vector machines...
The relationship between respiratory symptoms and frailty: findings from observational and Mendelian randomization analyses
CONCLUSIONS: Our study identified a potential association between frailty and respiratory symptoms. Inflammation and ageing may be essential factors mediating this association.
A brief report on biomarkers of cellular senescence associated with liver frailty and length of stay in liver transplantation
The proportion of older individuals needing liver transplantation is growing, resulting in an increasingly frail patient population. Frailty constitutes a constellation of cognitive and physical symptoms associated with aging and increases the risk of morbidity and mortality. Senescence is a programmed cell fate in response to stress implicated in causing frailty, age-related diseases, and aging itself. This study explores the relationship between cellular senescence, physical frailty, and liver...
Clin-STAR Corner: Practice Changing Advances at the Interface of Oncology and Geriatrics
Cancer and aging are inextricably linked, and older adults are a significant proportion of those diagnosed, treated, and living with and beyond a cancer diagnosis. Several large prospective studies have enhanced our understanding of how to improve the assessment, treatment, and outcomes of older adults with cancer starting therapy. This article summarizes three recent high-impact trials that produced practice-changing implications for the management of older adults with cancer that led to...
Examining Factors Influencing Older Adult Engagement in Fall Prevention: A Comparative Analysis Among Stakeholders
CONCLUSIONS: These findings demonstrate a variety of barriers across stakeholder types and provide valuable insights for developing strategies to effectively promote older adult participation in fall prevention activities to reduce falls and enhance healthy aging.