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Earliest amniote tracks recalibrate the timeline of tetrapod evolution
Chicago <i>Archaeopteryx</i> informs on the early evolution of the avian bauplan
A human-specific enhancer fine-tunes radial glia potency and corticogenesis
Divergent DNA methylation dynamics in marsupial and eutherian embryos
Proton transport from the antimatter factory of CERN
Encapsulated Co–Ni alloy boosts high-temperature CO<sub>2</sub> electroreduction
Taurine from tumour niche drives glycolysis to promote leukaemogenesis
Radiation-induced amphiregulin drives tumour metastasis
Exploring pathways for world development within planetary boundaries
Past warm intervals inform the future South Asian summer monsoon
Structured ionized winds shooting out from a quasar at relativistic speeds
How to transport antimatter — stick it on the back of a van
Take <i>Nature</i>’s AI research test: find out how your ethics compare
Is it OK for AI to write science papers? <i>Nature</i> survey shows researchers are split
Kennedy, Trump’s health chief, confronts criticism and praise from U.S. lawmakers
Budget cuts to NIH and other health agencies a major focus of congressional hearings
Low-quality papers are surging by exploiting public data sets and AI
Paper mills are also likely contributing to “false discoveries”
Africa’s manatees are highly elusive. A new DNA test promises to reveal their presence
Genetic traces in water could help survey populations under growing threat
Chaperone-mediated autophagy manipulates PGC1α stability and governs energy metabolism under thermal stress
Thermogenic proteins are down-regulated under thermal stress, including PGC1α· However, the molecular mechanisms are not fully understood. Here, we addressed that chaperone-mediated autophagy could regulate the stability of PGC1α under thermal stress. In mice, knockdown of Lamp2a, one of the two components of CMA, in BAT showed increased PGC1α protein and improved metabolic phenotypes. Combining the proteomics of brown adipose tissue (BAT), structure prediction, co-immunoprecipitation- mass...
pS396/pS404 (PHF1) tau vaccine outperforms pS199/pS202 (AT8) in rTg4510 tauopathy model
Tauopathies, including Alzheimer's disease (AD) and Frontotemporal Dementia (FTD), are histopathologically defined by the aggregation of hyperphosphorylated pathological tau (pTau) as neurofibrillary tangles in the brain. Site-specific phosphorylation of tau occurs early in the disease process and correlates with progressive cognitive decline, thus serving as targetable pathological epitopes for immunotherapy development. Previously, we developed a vaccine (Qβ-pT181) displaying phosphorylated...
Multiplex imaging of amyloid-β plaques dynamics in living brains with quinoline-malononitrile-based probes
The dynamic behaviour of amyloid-β (Aβ) plaques in Alzheimer's disease remains poorly understood, and accumulation and distribution of Aβ plaques must be inferred from in vitro pathological changes in brain tissue. In situ detection of Aβ plaques in live imaging is challenging because of the lack of adequate probes. Here we report the design of unimolecular quinoline-malononitrile-based Aβ probes, termed QMFluor integrative framework, that binds in vivo to Aβ plaques, making them detectable via...