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Science, Volume 387, Issue 6734, February 2025.

Science, Volume 387, Issue 6734, February 2025.

Science, Volume 387, Issue 6734, February 2025.

Science, Volume 387, Issue 6734, February 2025.

Science, Volume 387, Issue 6734, February 2025.

The Journal of the Academy of Public Health claims to open up scientific communication. But its unusual editorial policies have some scientists concerned

“Unethical, unlawful, inhumane”: NIH-backed scientist decries termination of study collecting data on sexual orientation and gender identity of cancer patients

Research centers move to reduce salaries and lay off staff

After chaotic halt, PEPFAR’s global distribution of HIV treatments may be resuming but limits on using drugs to curb viral spread remain

Trump could propose slashing agency’s budget by two-thirds

Move by tribe in northern Canada could complicate efforts to study earliest moments on planet

Alzheimer's disease (AD) is the most common neurodegenerative brain disease and represents the most frequent type of dementia characterized by cognitive impairment and amnesia. AD neuropathology is connected to the development of synaptic dysfunction and loss of synaptic homeostasis due to an imbalance in the production and clearance of β-amyloid (Aβ) and intracellular neurofibrillary tangles (NFTs). However, AD neuropathology is complex and may relate to the deposition of other misfolded...

An artificial intelligence (AI)-enabled electrocardiogram (ECG) model has been developed in a healthy adult population to predict ECG biological age (ECG-BA). This ECG-BA exhibited a robust correlation with chronological age (CA) in healthy adults and additionally significantly enhanced the prediction of aging-related diseases' onset in adults with subclinical diseases. The model showed particularly strong predictive power for cardiovascular and non-cardiovascular diseases such as stroke,...

Adults with Down syndrome are genetically predisposed to developing Alzheimer's disease after the age of 40. The cholinergic system, which is critical for cognitive functioning, is known to decline in Alzheimer's disease and although first investigated in individuals with Down syndrome 40 years ago, remains relatively understudied. Existing studies suggest individuals with Down syndrome have an intact cholinergic system at birth that declines through adulthood alongside the development of...

Recent discoveries have shown that systemic manipulation, such as parabiosis, blood exchange, and young plasma transfer, can counteract many hallmarks of aging. This rejuvenation effect has been attributed to circulatory factors produced by cells from both hematopoietic and non-hematopoietic lineages. However, the specific involvement of bone marrow (BM) or hematopoietic cells in producing such factors and their effects on aging is still unclear. We developed a model of aged mice with...

In neurons, the quantities of mRNAs and proteins are traditionally assumed to be determined by functional, electrical or genetic factors. Yet, there may also be global, currently unknown computational rules that are valid across different molecular species inside a cell. Surprisingly, our results show that the energy for molecular turnover is a significant cellular expense, en par with spiking cost, and which requires energy-saving strategies. We show that the drive to save energy determines...