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Science, Volume 389, Issue 6760, Page 594-599, August 2025.

Science, Volume 389, Issue 6760, Page 586-587, August 2025.

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Science, Volume 389, Issue 6760, Page 582-582, August 2025.

Foreign aid cuts are expected to cause a rise in malaria cases and deaths across sub-Saharan Africa

Cuts could erase promised boost, researchers fear

The metal is depleted in brains of people with disease and can reverse memory symptoms in mice, new study shows

Insulin resistance is a risk factor for Alzheimer's disease (AD). Chen et al.¹ show that microglial insulin signaling is essential for metabolic homeostasis and immune regulation, while insulin resistance impairs Aβ clearance and promotes neuroinflammation in AD. Their findings reframe AD pathogenesis through a cell-type-specific lens.

The earliest molecular changes in Alzheimer's disease (AD) are poorly understood^(1-5). Here we show that endogenous lithium (Li) is dynamically regulated in the brain and contributes to cognitive preservation during ageing. Of the metals we analysed, Li was the only one that was significantly reduced in the brain in individuals with mild cognitive impairment (MCI), a precursor to AD. Li bioavailability was further reduced in AD by amyloid sequestration. We explored the role of endogenous Li in...

CONCLUSION: Research in this field has garnered substantial attention in recent years. This bibliometric analysis not only underscores the correlation between cellular senescence and skeletal diseases, but also highlights that targeting cellular senescence and the SASP may offer potential therapeutic strategies. These findings can inform future research directions and the development of targeted interventions for age-related skeletal conditions.

The blood-brain barrier (BBB) preserves brain health through selective permeability, and its disruption is a hallmark of many neurological disorders. Mechanical stimuli such as shear stress and cyclic strain are increasingly recognised to influence BBB integrity and function, while alterations in tissue stiffness and extracellular matrix composition contribute to its breakdown during ageing and disease. Despite its importance, BBB mechanobiology remains underexplored. Here we highlight the...

Aging increases the risk of developing fibrotic diseases by hampering tissue regeneration after injury. Using longitudinal single-cell RNA-seq and spatial transcriptomics, here we compare the transcriptome of bleomycin (BLM) -induced fibrotic lungs of young and aged male mice, at 3 time points corresponding to the peak of fibrosis, regeneration, and resolution. We find that lung injury shifts the transcriptomic profiles of three pulmonary capillary endothelial cells (PCEC) subpopulations. The...

The earliest molecular changes in Alzheimer's disease (AD) are poorly understood^(1-5). Here we show that endogenous lithium (Li) is dynamically regulated in the brain and contributes to cognitive preservation during ageing. Of the metals we analysed, Li was the only one that was significantly reduced in the brain in individuals with mild cognitive impairment (MCI), a precursor to AD. Li bioavailability was further reduced in AD by amyloid sequestration. We explored the role of endogenous Li in...

Semantic processing remains relatively preserved during healthy aging, but the mechanisms are poorly understood. Herein, we use dynamic functional mapping based on magnetoencephalography to examine the neural oscillations serving semantic processing across the adult lifespan (N = 154; 21-87 years). Task-related oscillatory dynamics were imaged using a beamformer and whole-brain linear mixed-effects (LME) models were calculated with age and task condition (semantically-related or -unrelated) as...