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A wheat tandem kinase activates an NLR to trigger immunity

7 months 1 week ago
Science, Volume 387, Issue 6741, Page 1402-1408, March 2025.
Renjie Chen, Jian Chen, Oliver R. Powell, Megan A. Outram, Taj Arndell, Karthick Gajendiran, Yan L. Wang, Jibril Lubega, Yang Xu, Michael A. Ayliffe, Cheryl Blundell, Melania Figueroa, Jana Sperschneider, Thomas Vanhercke, Kostya Kanyuka, Dingzhong Tang,…

Full freedom-of-motion actuators as advanced haptic interfaces

7 months 1 week ago
Science, Volume 387, Issue 6741, Page 1383-1390, March 2025.
Kyoung-Ho Ha, Jaeyoung Yoo, Shupeng Li, Yuxuan Mao, Shengwei Xu, Hongyuan Qi, Hanbing Wu, Chengye Fan, Hanyin Yuan, Jin-Tae Kim, Matthew T. Flavin, Seonggwang Yoo, Pratyush Shahir, Sangjun Kim, Hak-Young Ahn, Edward Colgate, Yonggang Huang, John A. Rogers

Activity-dependent regulation of Cdc42 by Ephexin5 drives synapse growth and stabilization

7 months 1 week ago
Synaptic Rho guanosine triphosphatase (GTPase) guanine nucleotide exchange factors (RhoGEFs) play vital roles in regulating the activity-dependent neuronal plasticity that is critical for learning. Ephexin5, a RhoGEF implicated in the etiology of Alzheimer's disease and Angelman syndrome, was originally reported in neurons as a RhoA-specific GEF that negatively regulates spine synapse density. Here, we show that Ephexin5 activates both RhoA and Cdc42 in the brain. Furthermore, using live imaging...
Samuel Petshow

Age and gender differences in health characteristics of older people with visual impairment

7 months 1 week ago
CONCLUSION: The prevalence of VI is high older (> 55 years) adults in Cameroon, with clear differences between men and women. The oldest individuals, and women appear to be most vulnerable. The identification of at-risk groups/persons through this cross-sectional study should make it possible to adapt public health strategies to contribute to the WHO objective of healthy ageing.
Salvatore Metanmo