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Blue zones, supposed havens of longevity, have become a global brand. But skeptics think they rest on shaky science.

CONCLUSIONS: Videoconference based neuropsychological assessment can be as precise as in-person. Calibration of ability estimates using latent variable measurement models can address measurement differences and generate scores without evidence of systematic bias.

Identifying early predictors of cognitive decline and at-risk individuals is essential for timely intervention and prevention of dementia. This study aimed to detect neurobiological changes and factors related to cognitive performance in the Metropolit 1953 Danish male birth cohort. We analyzed data from 582 participants, aged 57-68 years, using machine learning techniques to group cognitive trajectories into four clusters differentiating high- and low-performing groups. These clusters were then...

Prior studies have shown that interrupting the growth hormone/insulin-like growth factor-I (GH/IGF-I) signaling axis extends laboratory mouse lifespan, but confounding effects of additional gene or hormone deficiencies that exist in commonly used models of GH/IGF-I interruption obscure the specific effect of GH on longevity. We address this issue by using mice with a specific knockout of the GH gene and show that both males and females on a mixed genetic background display extended lifespans...

Science, Volume 386, Issue 6724, November 2024.

Science, Volume 386, Issue 6724, Page 862-864, November 2024.

Science, Volume 386, Issue 6724, Page 853-856, November 2024.

Science, Volume 386, Issue 6724, Page 831-831, November 2024.

Science, Volume 386, Issue 6724, Page 834-835, November 2024.