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World first: ultra-powerful CRISPR treatment trialled in a person
Mother–infant bonds in wild chimpanzees resemble those of humans
AI tool flags people at high risk of post-partum depression
Author Correction: Inhibitory specificity from a connectomic census of mouse visual cortex
Genomics reveals zoonotic and sustained human Mpox spread in West Africa
Author Correction: Soft–hard zwitterionic additives for aqueous halide flow batteries
Targeting the chromatin remodeler BAZ2B mitigates hepatic senescence and MASH fibrosis
Hurricane risk in a changing climate — the role of uncertainty
When the government cancels your research grant, here’s what you can do
Mighty microbes — the invisible forces that can save the world
Exclusive: NIH grant rejections have more than doubled amid Trump chaos
People and dogs team up to protect sea turtles in Cabo Verde
Trump’s science adviser defends funding cuts as a chance to ‘revitalize’ U.S. science
Michael Kratsios says DEI has led to a loss of public trust in universities
30-day forecast? Weather prediction might be able to look beyond 2 weeks
AI models suggest the true limits of the "butterfly effect" remain unknown
PHGDH-mediated serine synthesis in astrocytes supports neuroinflammation by sustaining NADH level to promote histone acetylation
Neuroinflammation contributes to the loss of dopamine neurons and motor dysfunctions in Parkinson's disease (PD). How cell metabolism regulates neuroinflammation by modulating epigenetic modifications is largely unknown. In this study, we found that the expression of phosphoglycerate dehydrogenase (PHGDH) which catalyzes the first step of the de novo serine synthesis pathway was mainly expressed in astrocytes and l-methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP) injection triggered the...
VPS33B-dependent exosomes modulate cellular senescence of mesenchymal stem cells via an autocrine signaling pathway
Mesenchymal stem cell (MSC)-derived exosomes have been intensively studied for their therapeutic effects on tissue repair and regeneration. However, the specific contributions of exosomes derived from endogenous bone marrow MSCs to the maintenance of bone tissue homeostasis remain unclear. In this study, we impaired MSC-derived exosome secretion by specifically deleting vascular protein sorting 33B (VPS33B). Mice deficient in VPS33B (VPS33B-cKO mice) exhibited premature bone loss and imbalanced...
Distinct systemic impacts of Aβ42 and Tau revealed by whole-organism snRNA-seq
Both neuronal and peripheral tissues become disrupted in Alzheimer's disease (AD). However, a comprehensive understanding of how AD impacts different tissues across the whole organism is lacking. Using Drosophila, we generated an AD Fly Cell Atlas (AD-FCA) based on whole-organism single-nucleus transcriptomes of 219 cell types from flies expressing AD-associated proteins, either human amyloid-β 42 peptide (Aβ42) or Tau, in neurons. We found that Aβ42 primarily affects the nervous system,...
Regulatory asymmetry in Alzheimer's disease care
No abstract
p16-expressing microglia and endothelial cells promote tauopathy and neurovascular abnormalities in PS19 mice
Cellular senescence is characterized by irreversible cell-cycle exit, a pro-inflammatory secretory phenotype, macromolecular damage, and deregulated metabolism. Senescent cells are highly associated with age-related diseases. We previously demonstrated that targeted elimination of senescent cells prevents neurodegenerative disease in tau (MAPT^(P301S);PS19) mutant mice. Here, we show that genetic ablation of the senescence mediator p16^(Ink4a) is sufficient to attenuate senescence signatures in...
Distinct systemic impacts of Aβ42 and Tau revealed by whole-organism snRNA-seq
Both neuronal and peripheral tissues become disrupted in Alzheimer's disease (AD). However, a comprehensive understanding of how AD impacts different tissues across the whole organism is lacking. Using Drosophila, we generated an AD Fly Cell Atlas (AD-FCA) based on whole-organism single-nucleus transcriptomes of 219 cell types from flies expressing AD-associated proteins, either human amyloid-β 42 peptide (Aβ42) or Tau, in neurons. We found that Aβ42 primarily affects the nervous system,...