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Human embryo research: how to move towards a 28-day limit
How fast are you ageing? Ordinary brain scans reveal the pace
Protect Iran’s scientists from attacks
Global pandemic agreement needs sustained pressure to succeed
Human space travel risks contaminating Mars
It should be free to apply to graduate school
Author Correction: Targeting the SHOC2–RAS interaction in RAS-mutant cancers
Association of midlife hearing impairment and hearing aid use with incident dementia: analysis of two UK-based longitudinal cohort studies
DunedinPACNI estimates the longitudinal Pace of Aging from a single brain image to track health and disease
Turmoil at US science academy as Trump cuts force layoffs
Should grant applicants judge competitors’ proposals? Unorthodox approach gets two real-world tests
Distributed peer review enlists more researchers in the process, but some may lack expertise
Methane tracker lost in space
For nearly 15 months, MethaneSAT helped pinpoint industrial emissions of potent greenhouse gas
Devices that pull water out of thin air poised to take off
Research “explosion” feeds tech that could cool data centers and slake the thirst of soldiers on the move
These tiny lasers are completely edible
Edible sensors made of glowing droplets could improve food and drug monitoring
Scattershot vaccination fails to slow mpox spread in Congo
Limited vaccine doses weren’t used strategically, WHO analysis finds
How do research careers compare across countries? New global database has some answers
Online tool from the Research and Innovation Careers Observatory allows users to compare salary, typical career destinations, and more
Dexmedetomidine improves functional activity of dopaminergic neurons in MPTP-treated mice
Preservation of functions in dopaminergic neurons is a potential medication strategy for Parkinson's disease (PD) during perioperative periods. An increasing number of studies have shown that Dexmedetomidine (DEX) plays a neuroprotective role in patients with neurological conditions. However, how DEX exerts its effects on dopaminergic neurons in PD remains unclear. In this research, we report that DEX enhanced the firing activity of dopaminergic neurons via activation of alpha2 (α2)...
Music-based intervention as a new therapeutic treatment for executive dysfunction in Parkinson's disease
Executive dysfunction is a prominent feature of cognitive impairment in Parkinson's disease (PD), affecting approximately 42% of patients. Due to the lack of effective treatment options for the executive dysfunction, it may lead to more severe gait disorder, dementia and be difficult to recuperate. Current studies indicate that music-based intervention (MBI) is an innovative and vital treatment for executive dysfunction. This review aims to describe the ideas-MBI for treating executive...
Neuronal glycogen breakdown mitigates tauopathy via pentose-phosphate-pathway-mediated oxidative stress reduction
Tauopathies encompass a range of neurodegenerative disorders, such as Alzheimer's disease (AD) and frontotemporal lobar degeneration with tau inclusions (FTLD-tau), for which there are currently no successful treatments. Here, we show impaired glycogen metabolism in the brain of a tauopathy Drosophila melanogaster model and people with AD, indicating a link between tauopathies and glycogen metabolism. We demonstrate that the breakdown of neuronal glycogen ameliorates the tauopathy phenotypes in...
Metabolomic Profiling Identifies Early Biomarkers of Frailty, Balance Impairment, and Fall Risks in Older Adults
CONCLUSION: Metabolomics offers a promising approach to identify early biomarkers of frailty, balance impairment, and fall risks in older adults. The integration of metabolic profiles with clinical assessments could lead to more precise and personalized healthcare interventions, improving fall prevention strategies and frailty management. Future studies with larger cohorts are needed to validate these findings and explore the clinical utility of Metabolomics in aging-related healthcare.