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Mapping the ionosphere with millions of phones
Task-agnostic exoskeleton control via biological joint moment estimation
Observation of Hilbert space fragmentation and fractonic excitations in 2D
Prefrontal transthalamic uncertainty processing drives flexible switching
Foundation models for fast, label-free detection of glioma infiltration
Clinical functional proteomics of intercellular signalling in pancreatic cancer
Fluorspar to fluorochemicals upon low-temperature activation in water
Photochemical permutation of thiazoles, isothiazoles and other azoles
Clearance of <i>p21</i> highly expressing senescent cells accelerates cutaneous wound healing
Thixotropic world
How AI is reshaping science and society
Postdocs count the cost of living in Ireland’s capital
Can AI review the scientific literature — and figure out what it all means?
Canada should sharply curtail research collaborations with China, lawmakers say
Report recommends an immediate ban on joint projects in a host of sensitive fields
First known double gravitational lens could shed light on universe’s expansion
Zigzagging light bent by perfectly aligned galaxies could improve estimates of Hubble constant
Satellite images reveal massive crop losses in war-torn Ukraine
As Russia’s invasion creeps inward, farmers are abandoning millions of hectares of farmland
A glowing, deep-diving sea slug mystified scientists. Now, it has a name
“Deep deceiver” adds a new branch to the nudibranch family tree
Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes
While apolipoprotein E (APOE) is the strongest genetic modifier for late-onset Alzheimer's disease (LOAD), the molecular mechanisms underlying isoform-dependent risk and the relevance of ApoE-associated lipids remain elusive. Here, we report that impaired low-density lipoprotein (LDL) receptor (LDLR) binding of lipidated ApoE2 (lipApoE2) avoids LDLR recycling defects observed with lipApoE3/E4 and decreases the uptake of cholesteryl esters (CEs), which are lipids linked to neurodegeneration. In...
Diagnosis of Alzheimer's disease using plasma biomarkers adjusted to clinical probability
Recently approved anti-amyloid immunotherapies for Alzheimer's disease (AD) require evidence of amyloid-β pathology from positron emission tomography (PET) or cerebrospinal fluid (CSF) before initiating treatment. Blood-based biomarkers promise to reduce the need for PET or CSF testing; however, their interpretation at the individual level and the circumstances requiring confirmatory testing are poorly understood. Individual-level interpretation of diagnostic test results requires knowledge of...
Root cap cell corpse clearance limits microbial colonization in <em>Arabidopsis thaliana</em>
Programmed cell death occurring during plant development (dPCD) is a fundamental process integral for plant growth and reproduction. Here, we investigate the connection between developmentally controlled PCD and fungal accommodation in Arabidopsis thaliana roots, focusing on the root cap-specific transcription factor ANAC033/SOMBRERO (SMB) and the senescence-associated nuclease BFN1. Mutations of both dPCD regulators increase colonization by the beneficial fungus Serendipita indica, primarily in...