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US brain drain: the scientists seeking jobs abroad amid Trump’s assault on research
<i>Nature</i> project to encourage early-career researchers in peer review is working
What an angry exchange with a reviewer taught me about arrogance and humility
My PhD adviser was fired and I was collateral damage. I learnt how to build resilience into graduate school
Six striking images showcase scientific fieldwork
Where do comets come from?
Author Correction: Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer
Reference centiles for intrinsic capacity to monitor clinical health outcomes in real-world primary care cohorts
US researchers must stand up to protect freedoms, not just funding
Do universities serve their community?
Empower communities to fight climate change at grassroots level
‘Loss and damage fund’ for climate change needs broader remit
China needs to deal with discarded electric-vehicle batteries
NSF board member resigns, saying Trump’s policies have harmed the agency
Alondra Nelson criticizes DOGE in taking an unprecedented step
Trump officials take steps toward a radically different NSF
Efforts to shrink staff, budget, and focus have alarmed members of Congress
AI conjures up potential new antibody drugs in a matter of months
Company finds candidates that bind to tricky proteins that deliver chemical messages in and out of cells
Comparisons of metabolites and gut microbiota profiles for both young and middle-aged APPSwe/PS1De9 mice
The research focused on exploring the differences and relationships between gut microbiota and metabolites at various stages of Alzheimer's disease (AD), specifically using APP/PS1 mice at the ages of 6 months and 10 months. To assess metabolites in serum and cortex, and to evaluate gut microbiota profiles in cecal content, UPLC-MS/MS and 16S rRNA sequencing techniques were utilized, respectively. Findings indicated that, in comparison to younger mice, serum concentrations of L-Leucine, thymine,...
Spatial mapping of the brain metabolome lipidome and glycome
Metabolites, lipids, and glycans are fundamental but interconnected classes of biomolecules that form the basis of the metabolic network. These molecules are dynamically channeled through multiple pathways that govern cellular physiology and pathology. Here, we present a framework for the simultaneous spatial analysis of the metabolome, lipidome, and glycome from a single tissue section using mass spectrometry imaging. This workflow integrates a computational platform, the Spatial Augmented...
Menopause, memory and molecular pathways: growing insights into Alzheimer disease risk in women
No abstract
Dementia with Lewy bodies and Parkinson disease dementia - the same or different and is it important?
Biological definitions of neurological diseases are now becoming a reality, although still in the research phase. This development will recategorize neurological diseases, providing objective diagnostics and the promise of therapeutics that target biological mechanisms - similar to the strategy that has proven successful in tumours and other conditions. In this Perspective article, we discuss this development for dementias with dominant Lewy pathology, as the availability of biological assays...