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Epigenetics and individuality: from concepts to causality across timescales

5 months 3 weeks ago
Traditionally, differences among individuals have been divided into genetic and environmental causes. However, both types of variation can underlie regulatory changes in gene expression - that is, epigenetic changes - that persist across cell divisions (developmental differentiation) and even across generations (transgenerational inheritance). Increasingly, epigenetic variation among individuals is recognized as an important factor in human diseases and ageing. Moreover, non-genetic inheritance...
Amy K Webster

The influencing factors of cognitive impairment in elderly individuals in Chengdu city: a cross-sectional study based on AD8

5 months 3 weeks ago
CONCLUSION: Cognitive impairment in elderly individuals in Chengdu is serious. We can intervene in and improve cognitive impairment in elderly people by controlling blood pressure and blood sugar, treating depressive and anxiety symptoms and developing community colleges for elderly people and increasing satisfaction with life.
Xi Ruan

Circulating metabolomic biomarkers of 5-year body weight and composition change in a biracial cohort of community-dwelling older adults

5 months 3 weeks ago
Unintentional weight loss in older populations is linked to greater mortality and morbidity risks. This study aims to understand the metabolic mechanisms of unintentional weight loss and their relationship with body composition changes in older adults. We investigated plasma metabolite associations with weight and body composition changes over 5 years in 1335 participants (mean age 73.4 years at Year 1, 51% women, and 33% Black) from the Health, Aging and Body Composition (Health ABC) study....
Shanshan Yao

Typology of Social Participation and Network and Health in Older Adults: Results From the Canadian Longitudinal Study on Aging

5 months 3 weeks ago
This study aimed to document the typology of social participation and network among older Canadians and examine their associations with health. Using 2011-2015 cross-sectional data from the Canadian Longitudinal Study on Aging, a latent profile analysis was conducted to identify patterns of social participation and network, and multinomial logistic regressions examined associations with self-rated health. Four types of social participation and networks characterized older Canadians: diverse...
Véronique Deslauriers

Intermittent Fasting Enhances Motor Coordination Through Myelin Preservation in Aged Mice

5 months 3 weeks ago
Integrating dietary interventions have been extensively studied for their health benefits, such as Alzheimer's disease, Huntington's disease, and aging. However, it is necessary to fully understand the mechanisms of long-term effects and practical applications of these dietary interventions for health. A 10-week intermittent fasting (IMF) regimen was implemented on the aging animals in the current study. The variations of cerebral functions were analyzed employing a comprehensive experimental...
Zhuang Liu

Intermittent Fasting Enhances Motor Coordination Through Myelin Preservation in Aged Mice

5 months 3 weeks ago
Integrating dietary interventions have been extensively studied for their health benefits, such as Alzheimer's disease, Huntington's disease, and aging. However, it is necessary to fully understand the mechanisms of long-term effects and practical applications of these dietary interventions for health. A 10-week intermittent fasting (IMF) regimen was implemented on the aging animals in the current study. The variations of cerebral functions were analyzed employing a comprehensive experimental...
Zhuang Liu

Cross-tissue comparison of epigenetic aging clocks in humans

5 months 3 weeks ago
Epigenetic clocks are a common group of tools used to measure biological aging-the progressive deterioration of cells, tissues, and organs. Epigenetic clocks have been trained almost exclusively using blood-based tissues, but there is growing interest in estimating epigenetic age using less-invasive oral-based tissues (i.e., buccal or saliva) in both research and commercial settings. However, differentiated cell types across body tissues exhibit unique DNA methylation landscapes and age-related...
Abner T Apsley

Deprescribing in Older Adults With Type 2 Diabetes: Associations With Patients' Perspectives: The Diabetes and Aging Study

5 months 3 weeks ago
CONCLUSIONS: Patients' perspectives may enable or hinder deprescribing, emphasizing the importance of soliciting these perspectives during shared decision-making. Effective deprescribing will benefit from understanding patients' perspectives and fostering patient-provider communication about medication changes throughout the disease course.
Melissa M Parker

In Science Journals

5 months 3 weeks ago
Science, Volume 387, Issue 6730, Page 149-151, January 2025.

Michael Funk, and
Jesse Smith,
Marc S. Lavine,
Bianca Lopez,
Brent Grocholski,
Sacha Vignieri,
Ian S. Osborne,
Mattia Maroso,
Allison Williams,
Corinne Simonti,
Stella M. Hurtley,
Priscilla N. Kelly,
Phil Szuromi,
Leslie K. Ferrarelli, and …