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Glaciation of liquid clouds, snowfall, and reduced cloud cover at industrial aerosol hot spots
Science, Volume 386, Issue 6723, Page 756-762, November 2024.
Synchronous recognition of amines in oxidative carbonylation toward unsymmetrical ureas
Science, Volume 386, Issue 6723, Page 776-782, November 2024.
High-temperature carbon dioxide capture in a porous material with terminal zinc hydride sites
Science, Volume 386, Issue 6723, Page 814-819, November 2024.
Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy
Science, Volume 386, Issue 6723, Page 768-776, November 2024.
Tomorrow’s trees
Science, Volume 386, Issue 6723, Page 733-733, November 2024.
A voyage to victory
Science, Volume 386, Issue 6723, Page 734-734, November 2024.
When it comes to science, U.S. Senate’s new leader has a buried past
Senator John Thune helped convert an abandoned South Dakota gold mine into a deep underground laboratory
With first mechanical qubit, quantum computing goes steampunk
Sapphire crystal’s vibrations used to make two-ways-at-once quantum bit
A breakthrough cancer immunotherapy is now taking aim at autoimmune disease
CAR-T therapy is generating excitement for lupus, scleroderma, and other conditions as clinical trials expand
Meet Evo, the DNA-trained AI that creates genomes from scratch
ChatGPT-like model learns on its own to devise new proteins and genetic sequences
News at a glance: Replication troubles, financial conflict disclosures, and a public health shake-up
The latest in science and policy
Why do humans mature so slowly? An ancient youth offers clues
Small-brained member of Homo that lived 1.8 million years ago may signal a step toward long, drawn-out childhoods
Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits
Several cardiovascular traits and diseases co-occur with Alzheimer's disease. We mapped their shared genetic architecture using multi-trait genome-wide association studies. Subsequent fine-mapping and colocalisation highlighted 16 genetic loci associated with both Alzheimer's and cardiovascular diseases. We prioritised rs11786896, which colocalised with Alzheimer's disease, atrial fibrillation and expression of PLEC in the heart left ventricle, and rs7529220, which colocalised with Alzheimer's...
Cognitive reserve against Alzheimer's pathology is linked to brain activity during memory formation
The cognitive reserve (CR) hypothesis posits that individuals can differ in how their brain function is disrupted by pathology associated with aging and neurodegeneration. Here, we test this hypothesis in the continuum from cognitively normal to at-risk stages for Alzheimer's Disease (AD) to AD dementia using longitudinal data from 490 participants of the DELCODE multicentric observational study. Brain function is measured using task fMRI of visual memory encoding. Using a multivariate...
Immune responses influence sex differences in Alzheimer disease
No abstract
Cognitive reserve against Alzheimer's pathology is linked to brain activity during memory formation
The cognitive reserve (CR) hypothesis posits that individuals can differ in how their brain function is disrupted by pathology associated with aging and neurodegeneration. Here, we test this hypothesis in the continuum from cognitively normal to at-risk stages for Alzheimer's Disease (AD) to AD dementia using longitudinal data from 490 participants of the DELCODE multicentric observational study. Brain function is measured using task fMRI of visual memory encoding. Using a multivariate...
The mitochondrial mRNA-stabilizing protein SLIRP regulates skeletal muscle mitochondrial structure and respiration by exercise-recoverable mechanisms
Decline in mitochondrial function is linked to decreased muscle mass and strength in conditions like sarcopenia and type 2 diabetes. Despite therapeutic opportunities, there is limited and equivocal data regarding molecular cues controlling muscle mitochondrial plasticity. Here we uncovered that the mitochondrial mRNA-stabilizing protein SLIRP, in complex with LRPPRC, is a PGC-1α target that regulates mitochondrial structure, respiration, and mtDNA-encoded-mRNA pools in skeletal muscle. Exercise...
Common protein-altering variant in GFAP is associated with white matter lesions in the older Japanese population
The genetic architecture of white matter lesions (WMLs) in Asian populations has not been well-characterized. Here, we performed a genome-wide association study (GWAS) to identify loci associated with the WML volume. Brain MRI and DNA samples were collected from 9479 participants in the Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD). The GWAS confirmed three known WML-associated loci (SH3PXD2A, GFAP, and TRIM47). The lead variant of GFAP was a common missense variant...
Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFbeta
Cellular senescence is not only associated with ageing but also impacts physiological and pathological processes, such as embryonic development and wound healing. Factors secreted by senescent cells affect their microenvironment and can induce spreading of senescence locally. Acute severe liver disease is associated with hepatocyte senescence and frequently progresses to multi-organ failure. Why the latter occurs is poorly understood. Here we demonstrate senescence development in extrahepatic...
A systemic effect for liver senescence
No abstract