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Cognitive synaptopathy: synaptic and dendritic spine dysfunction in age-related cognitive disorders
Cognitive impairment is a leading component of several neurodegenerative and neurodevelopmental diseases, profoundly impacting on the individual, the family, and society at large. Cognitive pathologies are driven by a multiplicity of factors, from genetic mutations and genetic risk factors, neurotransmitter-associated dysfunction, abnormal connectomics at the level of local neuronal circuits and broader brain networks, to environmental influences able to modulate some of the endogenous factors....
Two weeks of exercise alters neuronal extracellular vesicle insulin signaling proteins and pro-BDNF in older adults with prediabetes
Adults with prediabetes are at risk for Alzheimer's Disease and Related Dementia (ADRD). While exercise may lower ADRD risk, the exact mechanism is unclear. We tested the hypothesis that short-term exercise would raise neuronal insulin signaling and pro-BDNF in neuronal extracellular vesicles (nEVs) in prediabetes. Twenty-one older adults (18F, 60.0 ± 8.6 yrs.; BMI: 33.5 ± 1.1 kg/m²) with prediabetes (ADA criteria; 75 g OGTT) were randomized to 12 supervised work-matched continuous (n = 13, 70%...
Daily briefing: Mega-magnet breaks field record — but it comes with a cost
How does the brain react to birth control? A researcher scanned herself 75 times to find out
The huge protein database that spawned AlphaFold and biology’s AI revolution
How I created a film festival to explore climate communication
A hematology-based clock derived from the Study of Longitudinal Aging in Mice to estimate biological age
China builds record-breaking magnet — but it comes with a cost
The speed of smell is faster than expected
The development and impact of tin selenide on thermoelectrics
Science, Volume 386, Issue 6719, October 2024.
In vivo dendritic cell reprogramming for cancer immunotherapy
Science, Volume 386, Issue 6719, October 2024.
AI can help humans find common ground in democratic deliberation
Science, Volume 386, Issue 6719, October 2024.
Mechanism of bacterial predation via ixotrophy
Science, Volume 386, Issue 6719, October 2024.
Global rise in forest fire emissions linked to climate change in the extratropics
Science, Volume 386, Issue 6719, October 2024.
Megastudy testing 25 treatments to reduce antidemocratic attitudes and partisan animosity
Science, Volume 386, Issue 6719, October 2024.
Genetic databases don’t fairly capture species richness of Global South, new data show
Two evolutionary biologists speak to Science about the disparities in how some geographic areas are represented in biodiversity research
AI reveals how sperm sticks to egg during fertilization
Two studies identify elusive protein complex with help from software developed by some of this year’s Nobel winners
Apolipoprotein E aggregation in microglia initiates Alzheimer's disease pathology by seeding beta-amyloidosis
The seeded growth of pathogenic protein aggregates underlies the pathogenesis of Alzheimer's disease (AD), but how this pathological cascade is initiated is not fully understood. Sporadic AD is linked genetically to apolipoprotein E (APOE) and other genes expressed in microglia related to immune, lipid, and endocytic functions. We generated a transgenic knockin mouse expressing HaloTag-tagged APOE and optimized experimental protocols for the biochemical purification of APOE, which enabled us to...
Exploring complexities of Alzheimer's disease: New insights into molecular and cellular mechanisms of neurodegeneration and targeted therapeutic interventions
Alzheimer's disease (AD), the common form of dementia globally, is a complex condition including neurodegeneration; shares incompletely known pathogenesis. Signal transduction and biological activities, including cell metabolism, growth, and death are regulated by different signaling pathways including AKT/MAPK, Wnt, Leptin, mTOR, ubiquitin, Sirt1, and insulin. Absolute evidence linking specific molecular pathways with the genesis and/or progression of AD is still lacking. Changes in gut...
Harnessing Brainwave Entrainment: A Non-invasive Strategy To Alleviate Neurological Disorder Symptoms
From 1990-2019, the burden of neurological disorders varied considerably across countries and regions. Psychiatric disorders, often emerging in early to mid-adulthood, are linked to late-life neurodegenerative diseases like Alzheimer's disease and Parkinson's disease. Individuals with conditions such as Major Depressive Disorder, Anxiety Disorder, Schizophrenia, and Bipolar Disorder face up to four times higher risk of developing neurodegenerative disorders. Contrarily, 65 % of those with...