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Ghrelin Receptor Deletion or Pharmacological Inhibition Improves Muscle Function in Aging Male Mice

5 months 2 weeks ago
Sarcopenia is characterized by age-related declines in muscle strength and mass, along with impaired physical function. It remains an unmet medical need, and there are no pharmacological interventions approved for this indication. The activation of growth hormone secretagogue receptor (GHSR)-1a, also known as ghrelin receptor, stimulates food intake and has acute anabolic effects. However, its impact on aging muscles remains uncertain. We examined the effects of GHSR-1a deletion on sarcopenia...
Haiming L Kerr

In Science Journals

5 months 2 weeks ago
Science, Volume 392, Issue 6795, Page 265-267, April 2026.
Michael Funk, and Madeleine Seale, Phil Szuromi, Keith T. Smith, Angela Hessler, Mattia Maroso, Stella M. Hurtley, Molly Ogle, Wei Wong, Marc S. Lavine, Yevgeniya Nusinovich, Sacha Vignieri, Sarah H. Ross, Di Jiang, and Claire Olingy