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Deciphering icosahedra structural evolution with atomically precise silver nanoclusters
Science, Volume 389, Issue 6763, Page 921-924, August 2025.
Classical-decisive quantum internet by integrated photonics
Science, Volume 389, Issue 6763, Page 940-944, August 2025.
Architecture of the UBR4 complex, a giant E4 ligase central to eukaryotic protein quality control
Science, Volume 389, Issue 6763, Page 909-914, August 2025.
Yellowstone’s free-moving large bison herds provide a glimpse of their past ecosystem function
Science, Volume 389, Issue 6763, Page 904-908, August 2025.
Land availability and policy commitments limit global climate mitigation from forestation
Science, Volume 389, Issue 6763, Page 931-934, August 2025.
Academic leadership in uncertain times
Science, Volume 389, Issue 6763, Page 882-882, August 2025.
Playing Possum: How Animals Understand Death
Science, Volume 389, Issue 6763, Page 883-883, August 2025.
Mars mania and the making of scientific authority
Science, Volume 389, Issue 6763, Page 883-883, August 2025.
Columbian mammoth mitogenomes from Mexico uncover the species’ complex evolutionary history
Science, Volume 390, Issue 6768, Page 47-52, October 2025.
Attempt to oust CDC director sparks key resignations by agency officials
Susan Monarez, who clashed with the U.S. health secretary over vaccine policy, refuses to step down
Mammoths in Mexico? Huge bone trove reveals giant beasts thrived in warmth, too
Fossils found while building airport contain first mammoth DNA from tropical location
Glow-in-the-dark particles let succulents shine in the dark
New technique lets popular houseplants glow for a little while—without genetic engineering
Study shows how the human pelvis was reshaped for upright walking
Comparisons of pelvic development in human and primate embryos reveals key steps in human evolution
Here’s how the first proteins might have assembled, sparking life
RNA could have helped amino acids join up without preexisting protein machinery, lab study suggests
Amyloid-β oligomers, curvilinear and annular assemblies, imaged by cryo-ET, cryo-EM, and AFM
Prefibrillar structures of the amyloid-β (Aβ) peptide are central to cytotoxicity in Alzheimer's disease. Time-resolved imaging of oligomers has enabled quantification of their extension. A snapshot of these prefibrillar assemblies has been characterized using a combination of cryo-electron tomography (cryo-ET), cryo-electron microscopy (cryo-EM) single-particle analysis, and atomic force microscopy (AFM). A highly consistent diameter for all curvilinear protofibrils and oligomers of 2.8...
Gut-brain nexus: Mapping multimodal links to neurodegeneration at biobank scale
Alzheimer's disease (AD) and Parkinson's disease (PD) are influenced by genetic and environmental factors. We conducted a biobank-scale study to (i) identify endocrine, nutritional, metabolic, and digestive disorders with potential causal or temporal associations with AD/PD risk before diagnosis; (ii) assess plasma biomarkers' specificity for AD/PD in the context of co-occurring gut related traits and disorders; and (iii) integrate multimodal datasets to enhance AD/PD prediction. Our findings...
Putative PINK1/Parkin activators lower the threshold for mitophagy by sensitizing cells to mitochondrial stress
The PINK1/Parkin pathway targets damaged mitochondria for degradation via mitophagy. Genetic evidence implicates impaired mitophagy in Parkinson's disease, making its pharmacological enhancement a promising therapeutic strategy. Here, we characterize two mitophagy activators: a novel Parkin activator, FB231, and the reported PINK1 activator MTK458. Both compounds lower the threshold for mitochondrial toxins to induce PINK1/Parkin-mediated mitophagy. However, global proteomics revealed that FB231...
Structural insights into the activation of TMEM175 by small molecule
The upregulation of transmembrane protein 175 (TMEM175) has the potential to improve Parkinson's disease (PD) by aiding in the removal of α-synuclein aggregates. Understanding the structural basis of TMEM175 agonisms is crucial for uncovering its therapeutic potential for PD. Here, we have identified the first cryo-electron microscopy (cryo-EM) structure of human TMEM175 complexes with three agonists: DCY1020, DCY1040, and TUG-891. An open state of TMEM175 is unequivocally captured, laying the...
Biomolecular phase separation of microtubule-associated protein Tau and its role in the genesis of Brain Disorders
Microtubule-associated tau (MAP) is a crucial component for cellular cytoskeleton stability. However, upon hyperphosphorylation, these tau proteins detach from microtubules, leading to the genesis of clumpy fibrillar-rich β or paired helical filamental structures known as amyloids. Such deposits predispose a multitude of fatal disorders, including Alzheimer's Disease. The initial event behind such genesis is still a mystery. Today, numerous research studies try to untangle the initial events...
Breaking shackles of molecular weight and emission for NIR-II fluorophores by regulating Columb attraction interaction
The second near-infrared (NIR-II) dyes provide advantages for in vivo imaging, but challenges persist. A primary issue is the lack of practicable strategies to balance emission wavelength and molecular weight, particularly for low-molecular-weight (<500 Da) NIR-II (λ(em) > 1000 nm) dyes. Here, we propose a strategy that tunes NIR-II emissions by reducing Coulomb attraction interaction, contrasting with traditional approaches that redshift absorption wavelengths through energy gap reduction....