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A mechanism for telomere-specific telomere length regulation

5 months 2 weeks ago
Telomere length is a critical determinant of telomere function and hence chromosome stability. Critically short telomeres induce cellular senescence and division arrest, which eventually may lead to devastating age-related degenerative diseases. Conversely, maintenance of telomere length is a hallmark of cancer. How telomere set-length is established and molecular mechanisms for telomere-specific length regulation remained unknown. Here, we detail a mechanism of a telomere-specific set-length...
Gabriela M Teplitz

Accurate detection of somatic single-nucleotide variants from bulk RNA-seq data using RNA-MosaicHunter

5 months 2 weeks ago
Somatic variants are increasingly recognized as contributors to diverse non-cancer, developmental, and aging-related disorders. However, most tools for detecting somatic single-nucleotide variants (sSNVs) were designed for DNA sequencing and primarily tailored to cancer datasets, leaving a critical gap in harnessing the rich potential of RNA-seq for sSNV identification, particularly in non-cancer tissues with low mutation rates. Here, we introduce RNA-MosaicHunter, a novel bioinformatic tool for...
August Yue Huang

Chinese Immune Multi-Omics Atlas

5 months 2 weeks ago
Science, Volume 391, Issue 6781, January 2026.
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Ontogeny of the spinal cord dorsal horn

5 months 2 weeks ago
Science, Volume 391, Issue 6781, January 2026.
Robert Brian Roome, Archana Yadav, Lydia Flores, Amrit K. Puarr, Diana Nardini, Alexander Richardson, Ronald R. Waclaw, Ruth M. Arkell, Vilas Menon, Jane E. Johnson, Ariel J. Levine

Bark microbiota modulate climate-active gas fluxes in Australian forests

5 months 2 weeks ago
Science, Volume 391, Issue 6781, January 2026.
Pok Man Leung, Luke C. Jeffrey, Sean K. Bay, Paula Gomez-Alvarez, Montgomery Hall, Scott G. Johnston, Johannes Dittmann, Elisabeth Deschaseaux‡, Billie Hopkins, Jasmine Haskell, Thanavit Jirapanjawat, Tess F. Hutchinson, Nicholas V. Coleman, Xiyang Dong,…

Deep contrastive learning enables genome-wide virtual screening

5 months 2 weeks ago
Science, Volume 391, Issue 6781, January 2026.
Yinjun Jia, Bowen Gao, Jiaxin Tan, Jiqing Zheng, Xin Hong, Wenyu Zhu, Haichuan Tan, Yuan Xiao, Liping Tan, Hongyi Cai, Yanwen Huang, Zhiheng Deng, Xiangwei Wu, Yue Jin, Yafei Yuan, Jiekang Tian, Wei He, Weiying Ma, Yaqin Zhang, Lei Liu, Chuangye Yan, Wei…

In Science Journals

5 months 2 weeks ago
Science, Volume 391, Issue 6781, Page 143-145, January 2026.
Michael Funk, and Stella M. Hurtley, Phil Szuromi, Sacha Vignieri, Bianca Lopez, Jelena Stajic, Jake S. Yeston, Mark E. Hay, Claire Olingy, Di Jiang, Mattia Maroso, Corinne Simonti, Caroline Ash, Priscilla N. Kelly, Peter Stern, John Foley, and Courtney…