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Exploring the sensitivity of episodic and spatial memory tests to healthy and pathological cognitive aging
INTRODUCTION: In an increasingly aging society, testing hippocampal-dependent cognition in a quick and low resource manner will be crucial in: assessing the potential benefits of lifestyle choices and interventions affecting cognitive ageing (such as those involving exercise, diet, and sleep); detecting pathological aging, such as in Alzheimer's disease, where hippocampal degeneration occurs relatively early on.
Daily briefing: A worst-case weather scenario drove deadly flooding in Texas
Will AI speed up literature reviews or derail them entirely?
The Māori values that make good sense in science
Efficient perovskite/silicon tandem with asymmetric self-assembly molecule
Author Correction: Adipose tissue retains an epigenetic memory of obesity after weight loss
Author Correction: Large-scale network analysis of the cerebrospinal fluid proteome identifies molecular signatures of frontotemporal lobar degeneration
FOXO3-enhanced mesenchymal progenitor cells impede aging in monkeys
Tau PET positivity marks early clinical transition in Alzheimer’s disease progression
Author Correction: Harnessing a noncanonical vestibular input in the head-direction network to rectify age-related navigational deficits
Rubbish years: how to boost lab group morale when world events crash in
Turbocharged ‘killer’ cells show promise for autoimmune disease
How monitoring a remote Finnish peatland helps climate science
‘It’s a nightmare.’ U.S. funding cuts threaten academic science jobs at all levels
“There is a lot of pressure to essentially leave the country or not pursue research,” one Ph.D. student says
Balance training improves postural control and performance-related prefrontal brain activation in healthy older adults: Results of a six-month randomized controlled training intervention
Age-related deterioration in postural control is an important factor decreasing quality of life. Functional neuroimaging studies have shown that the activation of the prefrontal cortex (PFC) during balancing is typically higher in older (OA) compared to younger adults (YA), probably reflecting a mechanism contributing to worsened balance control with aging. Here, we hypothesized that balance training (BAL) shifts PFC activation towards a more efficient pattern, enabling improved balance...
Identifying lifestyle risk factors that discriminate memory trajectories: Differential findings across racial and ethnic groups in older adults
INTRODUCTION: Differences in lifestyle factors contribute towards inequalities in dementia incidence and memory trajectories across racial and ethnic groups. We identifieded lifestyle risk factors that best discriminat memory trajectories in older adults without cognitive impairment.
Multi-omics strategies to decode the molecular landscape of cellular senescence
Cellular senescence is a conserved cellular program characterized by a permanent cell cycle arrest triggered by a variety of stressors. Originally described as a tumor-suppressive mechanism, it is now recognized to exert pleiotropic and context-dependent functions, contributing to key physiological processes such as embryogenesis and tissue repair, as well as to processes associated with aging and the development of age-related diseases. Unlike normal cells, senescent cells remain metabolically...
A physically and mentally active lifestyle relates to younger brain and cognitive age
Resistance to age-related pathological changes (brain maintenance), including Alzheimer's disease, cerebrovascular disease, and neurodegeneration may promote cognitive resilience in aging. However, how lifestyle and health profiles relate to successful cognitive and brain aging remains poorly understood. In a novel, deeply phenotyped cohort of 211 cognitively unimpaired older adults (age = 71.0 ± 7.4 years, 46% female), we characterized principal components of lifestyle and health using...
Association between the healthy eating index and sarcopenia in Chinese elderly: a cross-sectional study
CONCLUSION: Better diet quality, reflected by higher HEI scores, is associated with a lower prevalence of sarcopenia in older adults, highlighting the importance of nutrition in preventing sarcopenia.
The therapeutic potential of adiponectin and extracellular vesicles for promoting improved healthspan
The gradual decline in physiological functions that comes with aging contributes to a range of chronic diseases, such as Alzheimer's, type 2 diabetes, heart failure, and osteoarthritis. Significant advancements in human longevity due to socioeconomic development have resulted in a foreseeable and substantial strain on the global healthcare system. In fact, there is now a shift in research focus towards enhancing healthspan. As a result, the development of improved therapies for various chronic...