Aggregator
People are having fewer babies: Is it really the end of the world?
Exercise improves survival of some people with colon cancer, clinical trial shows
Small, affordable undergraduate research programmes changed my career and strengthen US science. Why cut them?
A baby benefits from personalized gene editing in the clinic
A sit in the sauna can save endangered frogs
Tiny Australian predator defies drought to recover from near-extinction
Teacher defies ban on evolution education in the 1920s
Targeting iron-associated protein Ftl1 in the brain of old mice improves age-related cognitive impairment
Why strong mentorship was essential for my career success in science
Battery prices are falling, so why are electric cars still so expensive?
Study protected waters newly opened up to fishing
China’s hydropower megaproject breaks ground
Include Indigenous Knowledge systems in climate reports
African countries must rethink health-care financing
Facing ‘impossible’ workload, USDA struggles to oversee lab animal welfare
Shrinking staff and other handicaps threaten enforcement of federal law that protects research animals
As salmon in Alaska plummet, scientists home in on a killer
Chinook in the Yukon River appear to be particularly vulnerable to a common parasite—and warming waters may be abetting the infection
The expanding role of the NLRP3 inflammasome from periodic fevers to therapeutic targets
Understanding and treating inflammation has proven a formidable challenge. The initiator and central motor of inflammation, the protein NLRP3, is an innate immune sentinel and nonspecific sensor of cellular perturbation. A wide array of inflammatory triggers prompts the formation of an NLRP3 'inflammasome' complex, leading to inflammatory interleukin-1 family cytokine release and pyroptotic cell death. Since gain-of-function mutations in NLRP3 were demonstrated to cause a rare autoinflammatory...
Non-histone lysine lactylation: Emerging roles in tumor biology and therapeutic implications
Lactate, a byproduct of glycolysis, was first identified to induce a novel post-translational modification (PTM) known as lysine lactylation (Kla) in 2019. Kla has been shown to regulate various biological processes, including transcription, metabolism, cell proliferation, and inflammatory responses, which are pivotal in both tumorigenesis and cellular aging. Initially, Kla was identified as an epigenetic marker on histones, where it regulates gene transcription. However, more recent studies...
Effects of resistance training on osteosarcopenia in community-dwelling postmenopausal Korean women: Randomised controlled ERTO-K trial
CONCLUSIONS: A 6-month program of progressive resistance exercise combined with nutritional support improved muscle mass and strength in postmenopausal women with osteosarcopenia. Although the HE group showed less improvement at earlier time points, their muscle strength and physical performance were comparable to those of the RE group by the end of the intervention.
Epigenetic age acceleration and midlife cognition: joint evidence from observational study and Mendelian randomization
The relationship between epigenetic age acceleration (EAA) and midlife cognitive function remains unclear, with limited causal evidence. We investigated this association in 1252 Black and White middle-aged adults from the Bogalusa Heart Study (BHS) and conducted a two-sample Mendelian randomization (MR) analysis using GWAS summary statistics for EAA (N = 34,710) and cognition (N ≤ 106,162). In BHS, higher Hannum age acceleration, PhenoAge acceleration, and GrimAge acceleration (GrimAA) were each...