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Author Correction: Senescent-like border-associated macrophages regulate cognitive aging via migrasome-mediated induction of paracrine senescence in microglia
See space fireworks and lightning spaghetti — September’s best science images
Trust in the sea-bed mining authority is fragile — here’s how to change that
Early efforts to understand the processes underlying bird migration
ZDHHC11-mediated palmitoylation alleviates chondrocyte senescence and serves as a therapeutic target for osteoarthritis
How to get the best night’s sleep: what the science says
Technology leaders should ‘pay back’ society to support the common good
Add a ‘speculation box’ to research papers
Make cities more walkable, in the real world and in virtual reality
AI tools could reduce the appeal of predatory journals
India and Pakistan share flood risks and must combine solutions
AI-generated ‘participants’ can lead social science experiments astray, study finds
Data produced by “silicon samples” depends on researchers’ exact choice of models, prompts, and settings
China bolsters controversial claim to Pacific languages with new museum
Nationalist narrative holds that Austronesian language and culture originated in China, not Taiwan
U.S. scientists gird for yet another government shutdown
Political impasse to hobble research agencies—and perhaps enable layoffs
Insects aren’t ‘little robots’—so scientists are rethinking their welfare
Science chats with an entomologist and an expert in animal ethics who are monitoring how researchers report on the ethical treatment of insects
How AIs responded to the 2024 U.S. presidential election—in real time
First-of-its-kind study captures how AI models’ behavior evolved through the campaign season
BAP31 represses endoplasmic reticulum stress-mediated apoptosis and alleviates neurodegeneration in Parkinson's disease
Excessive endoplasmic reticulum (ER) stress and neuronal apoptosis contribute to neurodegeneration in Parkinson's disease (PD). However, the molecular mechanisms underlying these perturbations and how they are directly regulated remain unclear. B cell receptor-associated protein 31 (BAP31), which is highly expressed in the ER, has been shown to participate mainly in regulating ER stress and apoptosis. Here, our results showed that BAP31 expression was dramatically decreased in PD. Notably,...
In-Hospital Professional Oral Health Management is Associated With Improved Outcomes in Older Adults With Acute Pneumonia
CONCLUSIONS AND IMPLICATIONS: POHM provided by hospital dentistry during the acute phase of pneumonia was significantly associated with improved clinical outcomes in older patients. These findings underscore the potential value of integrating hospital-based dental care into the multidisciplinary inpatient management of pneumonia in aging populations.
Dipole-dipole interaction-induced dense primitive solid-electrolyte interphase for high-power Ah-level anode-free sodium metal batteries
High-energy and resource-abundant anode-free sodium metal batteries suffer from limited lifespan owing to dendrite growth and rapid capacity fading at early stages, particularly at high rate and high capacity. Here we report a preliminary surface-passivation strategy by highly fluorinated electrolyte, instantly forming a dense inorganic-dominant primitive solid-electrolyte interphase. Driven by dipole-dipole interaction, the spontaneously formed solid-electrolyte interphase is sufficiently dense...
Multivalent binding of the tardigrade Dsup protein to chromatin promotes yeast survival and longevity upon exposure to oxidative damage
Tardigrades are remarkable in their ability to survive extreme environments. The damage suppressor (Dsup) protein is thought to contribute to their extreme resistance to reactive oxygen species (ROS) generated by irradiation. Here we show that expression of Ramazzottius varieornatus Dsup in Saccharomyces cerevisiae reduces oxidative DNA damage and extends lifespan in response to chronic oxidative genotoxicity. Dsup uses multiple modes of engagement with the nucleosomal H2A/H2B acidic patch,...