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Marine origins and freshwater radiations of the otophysan fishes
Science, Volume 390, Issue 6768, Page 65-69, October 2025.
A high-resolution molecular spin-photon interface at telecommunication wavelengths
Science, Volume 390, Issue 6768, Page 76-81, October 2025.
Two-dimensional diboron trioxide crystal composed by boroxol groups
Science, Volume 390, Issue 6768, Page 95-99, October 2025.
Strengthening nucleic acid biosecurity screening against generative protein design tools
Science, Volume 390, Issue 6768, Page 82-87, October 2025.
Climate-linked escalation of societally disastrous wildfires
Science, Volume 390, Issue 6768, Page 53-58, October 2025.
Ancient alleles drive contemporary climate adaptation in an alpine plant
Science, Volume 390, Issue 6768, Page 59-64, October 2025.
On prosthetics, printed organs, and pig hearts
Science, Volume 390, Issue 6768, Page 34-34, October 2025.
A computer scientist’s technological gamble
Science, Volume 390, Issue 6768, Page 35-35, October 2025.
Observation of undepleted phosphine in the atmosphere of a low-temperature brown dwarf
Science, Volume 390, Issue 6774, Page 697-701, November 2025.
Climate research organization cuts dozens of jobs
Coalition that runs premier climate modeling center faces rising costs and budget uncertainty
Made to order bioweapon? AI-designed toxins slip through safety checks used by companies selling genes
Researchers expose flaws in safeguards intended to block rogue actors from making bioweapons
Neurons can communicate via hidden network of nanotubes, study finds
Tubes in mouse and human brains may also influence spread of brain disease
New radioactive isotope therapies promise more targeted attacks on cancer
Recent clinical successes, and profits, have prompted a rush among pharma companies to try new isotopes and targeting strategies
China launches ambitious collaboration to map primate brains—including ours
25-year plan will tap brain-mapping prowess in two dozen countries to visualize the organ in unprecedented detail
Ancient DNA from horses slaughtered by Neanderthals sheds light on equine evolution
300,000-year-old genes are oldest ever recovered from open-air site
Disentangling associations between complex traits and cell types with seismic
Integrating single-cell RNA sequencing with Genome-Wide Association Studies (GWAS) can uncover cell types involved in complex traits and disease. However, current methods often lack scalability, interpretability, and robustness. We present seismic, a framework that computes a novel specificity score capturing both expression magnitude and consistency across cell types and introduces influential gene analysis, an approach to identify genes driving each cell type-trait association. Across over...
Synthetic chaperone based on Hsp90-Tau interaction inhibits Tau aggregation and rescues physiological Tau-Microtubule interaction
The accumulation of intracellular aggregates of Tau protein is one main hallmark of Alzheimer's disease (AD) and is the consequence of Tau conformational changes, increased phosphorylation, and self-association to form fibrillar aggregates. This pathological process prevents the physiological interaction of Tau with microtubules to the detriment of the structural integrity of neurons. In healthy cells, aberrant protein misfolding and aggregation are counteracted by chaperone proteins whose...
Timing of hormone replacement therapy could influence Alzheimer disease risk
No abstract
Parkinson disease is a fatty acidopathy
On the basis of extensive mechanistic research over three decades, Parkinson disease (PD) and related synucleinopathies have been proposed to be combined proteinopathies and lipidopathies. Evidence strongly supports a physiological and pathogenic interplay between the disease-associated protein α-synuclein and lipids, with a demonstrable role for lipids in modulating PD phenotypes in the brain. Here, we refine this hypothesis by proposing PD to be a disease specifically involving metabolic...
Large-scale visualization of alpha-synuclein oligomers in Parkinson's disease brain tissue
Parkinson's disease (PD) is a neurodegenerative condition characterized by the presence of intraneuronal aggregates containing fibrillar ɑ-synuclein known as Lewy bodies. These large end-stage species are formed by smaller soluble protein nanoscale assemblies, often termed oligomers, which are proposed as early drivers of pathogenesis. Until now, this hypothesis has remained controversial, at least in part because it has not been possible to directly visualize nanoscale assemblies in human brain...