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Neurocognitive and emotional benefits of choir singing and their mediating factors across adulthood
BACKGROUND: Our understanding on how cognitive and socioemotional well-being factors interact throughout adulthood has increased remarkably over the past decades, encouraging the use of cognitively engaging leisure activities, such as music, to promote healthy ageing. Choir singing has attracted particular interest in this regard with its established benefits on socioemotional well-being. Outside the clinical context, however, the cognitive and well-being effects induced by musical activities...
Cognitive frailty and cardiometabolic risk in middle-aged and older adults: evidence from the UK and China
CONCLUSIONS: Cognitive frailty is a consistent predictor of cardiometabolic risk across distinct populations, supporting integrated screening and prevention strategies targeting both cognitive and physical deficits in aging populations.
The association between playing Ma-jong, chess, and card games and cognitive function improvement in middle-aged and elderly Chinese: cross-sectional evidence from CHARLS
CONCLUSIONS: PMCC activities are associated with cognitive function improvement in middle-aged and elderly adults in China. These findings suggest that engaging in PMCC activities could serve as a potential protective factor for enhancing cognitive health in this population, providing a basis for incorporating PMCC into strategies aimed at promoting cognitive well-being and healthy aging.
Modulation of fenestrated vasculature in the median eminence and area postrema in response to neurotoxin exposure and its impairment in aging
Effective communication between the brain and peripheral tissues is crucial for homeostasis and health, and its impairment is a defining feature of aging. Circumventricular organs, characterized by the presence of fenestrated capillaries and absence of a blood-brain barrier (BBB), play a crucial role in controlling substance exchange between the brain and the blood. To date, adaptive changes in fenestrated vasculature in response to environmental insults remain poorly understood. In this study,...
Editorial: The open challenges of cognitive frailty: risk factors, neuropsychological profiles and psychometric assessment for healthy aging
No abstract
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Dissecting microbial communities with single-cell transcriptome analysis
Science, Volume 389, Issue 6764, September 2025.
Divergent FOXA1 mutations drive prostate tumorigenesis and therapy-resistant cellular plasticity
Science, Volume 389, Issue 6764, September 2025.
Systematic discovery and engineering of synthetic immune receptors in plants
Science, Volume 389, Issue 6764, September 2025.
Cooperative actions of interneuron families support the hippocampal spatial code
Science, Volume 389, Issue 6764, September 2025.
Lewy body dementia promotion by air pollutants
Science, Volume 389, Issue 6764, September 2025.
Epithelial tension controls intestinal cell extrusion
Science, Volume 389, Issue 6764, September 2025.