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Tissue-Specific Effects of Dietary Protein on Cellular Senescence Are Mediated by Branched-Chain Amino Acids
Dietary protein is a key regulator of healthy aging in both mice and humans. In mice, reducing dietary levels of the branched-chain amino acids (BCAAs) recapitulates many of the benefits of a low protein diet; BCAA-restricted diets extend lifespan, reduce frailty, and improve metabolic health, while BCAA supplementation shortens lifespan, promotes obesity, and impairs glycemic control. Recently, high protein diets have been shown to promote cellular senescence, a hallmark of aging implicated in...
Epigenetic Age Monitoring in Professional Soccer Players for Tracking Recovery and the Effects of Strenuous Exercise
Elite sports have become increasingly professionalized and personalized, with soccer players facing a high number of games per season. This trend presents significant challenges in optimizing training for peak performance and requires rigorous monitoring of athletes to prevent overload and reduce injury risks. The emerging field of epigenetic clocks offers promising new pathways for developing useful biomarkers that enhance training management. This study investigates the effects of intense...
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Early universe’s ‘little red dots’ may be black hole stars
Puzzling objects spotted by NASA’s JWST telescope may be entirely new class of celestial entity
Giant virus with record-long tail discovered in Pacific Ocean
Infecting marine plankton, the pathogen may use its extreme appendage to enter host cells
Prevalence and risk factors of abuse among older adults registered with health centers in Southern Tehran: a population-based study
CONCLUSION: The high prevalence underscores the need for routine screening in health centers and caregiver education programs.
Why space foods aren't just for space
No abstract
The 18S rRNA methyltransferase DIMT-1 regulates lifespan in the germline later in life
Specialized ribosomes help determine which proteins are synthesized, however, the influence of age on ribosome heterogeneity and whether dysregulation of this process drives organismal aging is unknown. Here we examined the role of ribosomal RNA (rRNA) methylation in maintaining appropriate translation as organisms age. In a directed RNAi screen, we identified 18S rRNA N6'-dimethyl adenosine (m^(6,2)A) methyltransferase, dimt-1, as a regulator of C. elegans lifespan and stress resistance. We...