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The Oregon National Primate Research Center could change its name and shift its focus to nonanimal studies

试验酿成灾难性悲剧后，受害者父母寻求问责，《科学》与 Retraction Watch 联合调查发现

Stripped-down behemoth promises new insights into how galaxies grow, astronomers say

Satellite data reveal in unprecedented detail how groundwater reservoirs permanently lose their ability to store water

More than half of AI “unicorns” have never published a paper or preprint

More than a year after failed clinical trial, Shanghai Jiao Tong University School of Medicine promises “serious action”

Popular AI-powered food apps may make calorie counting easier, but they may also leave out a surprisingly large part of the meal. Four apps underestimated calories and fat by about one-third when tested against carefully prepared meals. High-fat ketogenic dishes appeared to cause the most trouble, while carbohydrates were measured more consistently.

Scientists used CRISPR to make prostate cancer cells easier for the immune system to detect and destroy. The experimental treatment dramatically improved the effects of immunotherapy in mice and may offer hope for other hard-to-treat tumors.

Scientists discovered that damaged fat cells can become inflamed, lose their ability to store lipids, and eventually vanish, disrupting the body’s metabolism. The findings show that diabetes can result not only from excess fat, but also from losing the healthy fat tissue the body needs.

Scientists have identified a possible tipping point that helps determine whether Alzheimer’s-related brain changes lead to dementia. The key may lie in how the brain’s immune cells respond to plaques and tau, offering a promising new target for treatments designed to extend cognitive resilience.

Immunosenescence increases susceptibility to infection and reduces vaccine responsiveness, yet bulk transcriptomic clocks obscure the cellular heterogeneity underlying this process. Here, we present IDEAL-Age, an interpretable deep learning framework that operates directly on single-cell PBMC transcriptomes. Benchmarking against 35 methods across independent cohorts demonstrates superior predictive performance. The framework's interpretability uncovers linear and non-linear gene contribution...