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Collective homeostasis of condensation-prone proteins via their mRNAs
Design of facilitated dissociation enables timing of cytokine signalling
Arousal as a universal embedding for spatiotemporal brain dynamics
Volcanic crisis reveals coupled magma system at Santorini and Kolumbo
Diverging fish biodiversity trends in cold and warm rivers and streams
Tailoring polymer electrolyte solvation for 600 Wh kg<sup>−1</sup> lithium batteries
Ribonucleotide incorporation into mitochondrial DNA drives inflammation
Convergent evolution of diverse jaw joints in mammaliamorphs
SPP1 is required for maintaining mesenchymal cell fate in pancreatic cancer
Industry-compatible silicon spin-qubit unit cells exceeding 99% fidelity
The geoeconomic turn in decarbonization
How a dangerous tick-borne virus sneaks into the brain
A tweezer array with 6100 highly coherent atomic qubits
In a first, a gene therapy seems to slow Huntington disease
Small study suggests uniQure drug could be first successful treatment for devastating brain disorder
A ‘solar bump’ could help data centers recover wasted energy
Solar water heaters could recoup 8% of the electricity needs of AI computer farms
Trump visa policy requires universities to pay huge fee to hire foreign scholars
U.S. employers to pay $100,000 for every new H-1B visa
Frontoparietal functional dedifferentiation during naturalistic movie watching among older adults at risk of emotional vulnerability
Functional dedifferentiation, a hallmark of brain aging particularly evident within the frontoparietal network (FPN), has been extensively investigated in the context of cognitive decline, yet its implications for late-life mental health remain poorly understood. Leveraging naturalistic paradigm combined with gradient mapping techniques, the present study investigated FPN functional dedifferentiation-quantified by functional dispersion of FPN in the multidimensional gradient space-during...
The relationship between category-level neural differentiation and exploratory eye movements in healthy young and older adults
Age-related neural dedifferentiation, characterized by lower selectivity of neural responses in high-level sensory cortex, is thought to be a major contributor to age-related cognitive decline. However, the mechanisms that underlie dedifferentiation are poorly understood. Building on prior evidence that exploratory eye movements differ with age, we investigated the role that eye movement might play in age-related declines in neural selectivity. Healthy young and older adults underwent fMRI with...
A Rare Hematopoietic Stem Cell-Derived Megakaryocyte Progenitor Accumulates via Enhanced Survival and Contributes to Exacerbated Thrombopoiesis Upon Aging
Distinct routes of cellular production from hematopoietic stem cells (HSCs) have defined our current view of hematopoiesis. Recently, we and others have challenged classical views of platelet generation, demonstrating that megakaryocyte progenitors (MkPs) and ultimately platelets can be specified via an alternate and additive route of HSC-direct specification specifically during aging. This "shortcut" pathway generates hyperactive platelets likely to contribute to age-related platelet-mediated...
Mitochondrial respiratory chain deficiency is associated with an impaired skeletal muscle regenerative response and fibrosis in older men with HIV
Despite suppressive anti-retroviral therapy (ART), some older people with HIV show adverse ageing phenotypes, and the underlying mechanisms remain incompletely understood. We recruited 30 men with HIV aged ≥ 50 years and 15 well-matched men without HIV and performed histological analyses on skeletal muscle biopsies and plasma biomarker measurement, in combination with clinical and functional assessments. Men with HIV showed higher frequencies of frailty, pre-frailty, sarcopenia, and...