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Science, Volume 387, Issue 6735, Page 786-791, February 2025.

Science, Volume 387, Issue 6735, Page 791-796, February 2025.

Science, Volume 387, Issue 6735, Page 764-769, February 2025.

Science, Volume 387, Issue 6735, Page 750-758, February 2025.

Science, Volume 387, Issue 6735, Page 776-782, February 2025.

Science, Volume 387, Issue 6735, Page 724-724, February 2025.

Science, Volume 387, Issue 6735, Page 723-723, February 2025.

Organizers of USAID-funded studies grapple with ethical responsibilities to trial participants and collaborators

Largest ever analysis of feline bones from the country suggests the animals may have been prized exotic pets

The latest in science and policy

New approach for interpreting expressions in pets and livestock could improve animal welfare

Michael Lauer is second top official to leave amid agency upheaval

Unique nanostructures on insect’s wings help it camouflage among the trees

But some criticize “weak and formal” support for protests from scientific institutions

The reptiles appear to remember specific magnetic characteristics of preferred feeding sites

Lawrence Tabak held leadership roles in director’s office for 15 years

The CGG repeat expansions in the 5'-UTR regions of certain genes have been implicated in various neurodegenerative and muscular disorders. However, the underlying pathogenic mechanisms are not well understood. In this study, we explore the role of the small molecular chaperone HSPB1 in counteracting neurodegeneration induced by poly-glycine (poly-G) aggregates. Employing a reporter system, we demonstrate that CGG repeat expansions within the 5'-UTR of the GIPC1 gene produce poly-G proteins, by...

The Aβ(42)/Aβ(40) ratio in the cerebrospinal fluid (CSF) and the concentrations of neurofilament light (NfL) and total tau (t-tau) are changed in the early stages of Alzheimer's disease (AD)¹, but their neurobiological correlates are not entirely understood. Here, we used 5xFAD transgenic mice to investigate the associations between these CSF biomarkers and measures of cerebral Aβ, including Aβ(42)/Aβ(40) ratios in plaques, insoluble fibrillar deposits and soluble protofibrils. A high...

Alzheimer's disease (AD) poses a significant obstacle in today's healthcare landscape, with limited effective treatments. Recent studies have revealed encouraging findings about how exercise-triggered irisin might help slow down the advancement of AD. Irisin, a myokine, released during physical activity, has garnered significant attention for its pleiotropic effects, extending beyond its traditional role in metabolic regulation. This review explores irisin's multifaceted potential in combating...

In a recent work reported in Science, Zhang et al. untangle dynamic changes arising across aging in multiple cell populations within thirteen organs using single-cell transcriptomics and identify four distinct dynamic waves in which immune cells are the most affected populations.