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The pancreas, which helps control blood sugar in humans, may be critical part of shark immune system

A scoping review of community health education studies for dementia prevention was conducted to clarify the form, content, outcome indicators, evaluation tools, and effects of community health education interventions for dementia prevention and to inform future research in this area. This scoping review of community-based health education interventions for Alzheimer's disease prevention across eight databases identified five intervention approaches-culturally adapted interventions, health...

Non-neuronal glial cells in the brain, such as astrocytes, play essential roles in maintaining the functional integrity of neuronal cells. A growing body of evidence suggests that cellular senescence of astrocytes, characterized by loss of proliferative potential and secretion of neurotoxic cytokines, makes significant contribution to neurotoxicity in Alzheimer's disease and a wide range of other neurodegenerative diseases. This review discusses the beneficial effects of Δ133p53α, a natural p53...

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CONCLUSION: These results do not support a positive effect of residing at moderate altitude on elderly autonomy and independence, the latter being likely influenced by a combination of environmental, behavioral and social factors.

A scoping review of community health education studies for dementia prevention was conducted to clarify the form, content, outcome indicators, evaluation tools, and effects of community health education interventions for dementia prevention and to inform future research in this area. This scoping review of community-based health education interventions for Alzheimer's disease prevention across eight databases identified five intervention approaches-culturally adapted interventions, health...

The term healthspan has been widely used in academic literature, technical reports and brochures, however, it is unclear if the same definitions and operationalizations for healthspan are being used. The objective of the systematic review (registration number CRD42023404872) was to summarize definitions of healthspan and their operationalization searching using four databases: PubMed, Embase, Web of Science, and Scopus. Out of 14,551 records, 207 records met the inclusion criteria and 187...

The human eye is a complex organ integral to visual perception, comprising multiple structures, including the retina, cornea, and lens. Vision loss affects over 2.2 billion individuals globally, with conditions such as age-related macular degeneration, cataracts, glaucoma, and diabetic retinopathy responsible for a majority of visual-impairing conditions. Recent research highlights the critical roles of microRNAs (miRNAs)-small non-coding RNAs involved in post-transcriptional gene regulation-in...

Non-neuronal glial cells in the brain, such as astrocytes, play essential roles in maintaining the functional integrity of neuronal cells. A growing body of evidence suggests that cellular senescence of astrocytes, characterized by loss of proliferative potential and secretion of neurotoxic cytokines, makes significant contribution to neurotoxicity in Alzheimer's disease and a wide range of other neurodegenerative diseases. This review discusses the beneficial effects of Δ133p53α, a natural p53...

Cognitive decline with aging is a complex process involving multiple brain regions and molecular mechanisms. While the role of the canonical protein degradation function of the ubiquitin-proteasome system (UPS) has been well studied in the context of aging and age-associated memory loss, the non-proteolytic functions of ubiquitin activity remain poorly understood. Here, we investigated the role of lysine-63 (K63) polyubiquitination, the most abundant form of proteasome-independent...

CONCLUSIONS AND IMPLICATIONS: SPPB ≤11 points and CST ≥11.5 seconds more accurately identified the risk of incident IADL/BADL disability than previously recommended cutoff points. As both instruments were similar in predicting trajectories of incident disability, the CST may represent a more practical choice for clinical screening, given its simplicity and shorter administration time.

Prior research utilizing diffusion tensor imaging (DTI) to examine cerebral white matter microstructural integrity among adults has established that increasing age is associated with poorer white matter health. While age effects on DTI measures of white matter integrity have been shown to vary in strength across different white matter tracts, tract-specific effects may be secondary to a global impact of age on white matter health. Furthermore, this global age effect could result in...