Aggregator

Follow President Donald Trump’s impact on U.S. research and science globally

The “life-changing” fellowship will go to 1000 fewer students this year

Genetically edited gray wolf pups became instant media darlings—and drew hefty skepticism from scientists

Other countries, foundations, international groups are unable to replace billions lost in U.S. cuts

Despite its extreme heat waves, the country’s decadeslong warming trend amounts to half the global average

PURPOSE: This study aims to synthesize existing evidence on the effectiveness of nonpharmacological interventions designed to increase the intrinsic capacity (IC) of community-dwelling older adults.

Persistent microglial inflammation is a detrimental contributor to the progression of Parkinson disease (PD) pathology and related issues such as impaired adult hippocampal neurogenesis (AHN) and cognition. We conducted a 10-week exercise program with MPTP-treated mice to determine whether neuroinflammation can be addressed by aerobic exercise and elucidate its underlying regulatory mechanisms. Ten weeks of exercise significantly reduced PD-related pathology and enhanced AHN and memory. These...

No abstract

Aging is an inevitable biological process, driven in part by increased oxidative stress, which accelerates cellular damage and contributes to immune system dysfunction. Therefore, targeting oxidative stress has emerged as a potential strategy. Pyrroloquinoline quinone (PQQ), a potent antioxidant, has demonstrated significant efficacy in reducing oxidative stress and modulating immune responses, making it a promising therapeutic candidate. In this study, we investigated the effects of aging on...

CONCLUSION: MCT had beneficial effects on functional and cognitive performance in older adults, as assessed by the DT test. However, improvements in DT performance did not translate into better daily life activities. Although the 4-month detraining period negatively impacted DT performance, the results remained superior to baseline levels.

CONCLUSIONS: Both insufficient and excessive nighttime sleep at baseline were linked to diminished physical performance. For older adults, a nap duration approximately 50 min may be potentially optimal for maintaining grip strength. These findings highlight the importance of proper sleep management, particularly for men over 65 years old with low activity levels, in preserving physical function and reducing the risk of mobility decline.

Background: The assessment of appendicular skeletal muscle mass (ASM) is central to the diagnosis of sarcopenia (SA). We developed an anthropometric model for estimating ASM and tested its validity to identify SA and associated risk of disability (RSA) in older women. Methods: The equation was developed with 89 women (60-88 years, 72 ± 6 years), with a cross-validation sample of 12 women (60-84 years, 67 ± 5 years). Validity was determined through concordance between actual versus estimated...