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The effect of ambient air pollution (PM<sub>2.5</sub>) on dementia risk
Relics
The great brain clearance and dementia debate
Losing weight through better sleep
Sleep is essential — researchers are trying to work out why
The life aquatic: this board game lets you dip into marine ecology
Research round-up: sleep
How do I explain the publication gap I ended up with after a hostile manager?
New treatments to put insomnia to bed
Microbial warfare brought us CRISPR. What big breakthroughs could be next?
The infuriating, expensive road to a good night’s sleep
Unlocking the secrets of sleep
In Canadian election, top Conservative candidate vows to end ‘woke ideology’ in science funding
Pierre Poilievre’s Conservative Party is trying to topple Liberal government in 28 April election
NIH freezes all research grants to Columbia University
Amid negotiations with Trump, the university could risk losing nearly $700 million
Trump administration fires staff for flagship U.S. climate assessment
Move could open the door to using high-profile report to attack climate science
Tip60 HAT activators as therapeutic modulators for Alzheimer's disease
Reduced histone acetylation in the brain causes transcriptional dysregulation and cognitive impairment that are key initial steps in Alzheimer's disease (AD) etiology. Unfortunately, current treatment strategies primarily focus on histone deacetylase inhibition (HDACi) that causes detrimental side effects due to non-specific acetylation. Here, we test Tip60 histone acetyltransferase (HAT) activation as a therapeutic strategy for selectively restoring cognition-associated histone acetylation...
Endothelial IGF- 1R deficiency disrupts microvascular homeostasis, impairing skeletal muscle perfusion and endurance: implications for age-related sarcopenia
Aging is associated with a progressive decline in circulating insulin-like growth factor- 1 (IGF- 1) levels in humans, which has been implicated in the pathogenesis of sarcopenia. IGF- 1 is an anabolic hormone that plays a dual role in maintaining skeletal muscle health, acting both directly on muscle fibers to promote growth and indirectly by supporting the vascular network that sustains muscle perfusion. However, the microvascular consequences of IGF- 1 deficiency in aging muscle remain poorly...
Bilingualism and "brain reserve" in subregions of the hippocampal formation
With aging, the hippocampal formation shows variable structural atrophy, which is associated with a decline in cognitive performance. Bilingualism is related to higher hippocampal gray matter volume (GMV), potentially representing a form of brain reserve in aging. However, the differential influence of bilingualism on hippocampal subregions remains unclear. Thus, we investigated GMV differences and differences in age-GMV relationships between mono- and bilinguals in the hippocampal formation and...
Compression of morbidity by interventions that steepen the survival curve
Longevity research aims to extend the healthspan while minimizing the duration of disability and morbidity, known as the sickspan. Most longevity interventions in model organisms extend healthspan, but it is not known whether they compress sickspan relative to the lifespan. Here, we present a theory that predicts which interventions compress relative sickspan, based on the shape of the survival curve. Interventions such as caloric restriction that extend mean lifespan while preserving the shape...
Autophagy does not always decline with ageing
No abstract