Aggregator

New footage reveals spectral bats “hugging,” playing, and bringing food to their young

Aging is associated with declines in muscle mass, strength, aerobic capacity, and metabolic health, accompanied by increased low-grade inflammation. The purpose of this study was to assess the effects of 12 weeks of resistance training (RT) combined with minimal high-intensity interval training (HIIT), with or without polyphenol supplementation, on muscular, cardiovascular, metabolic, and inflammatory adaptations in healthy older adults. Forty-one men and women aged 55-70 years ingested either...

Understanding cellular and molecular drivers of age-related cognitive decline is necessary to identify targets to restore cognition at old age. Here we identify ferritin light chain 1 (FTL1), an iron-associated protein, as a pro-aging neuronal factor that impairs cognition. Using transcriptomic and mass spectrometry approaches, we detect an increase in neuronal FTL1 in the hippocampus of aged mice, the levels of which correlate with cognitive decline. Mimicking an age-related increase in...

Tissue-specific regulation of gene expression is essential for multicellular organisms, and RNA-binding proteins play central roles in these molecular processes. To determine how the Caenorhabditis elegans RNA-binding protein, ADR-1, regulates tissue-specific gene expression, we profiled the RNA-binding targets of ADR-1 in neural cells and assessed the effects of ADR-1 binding on neural gene expression. We identified a cohort of neural transcripts that function in lipid metabolism and are...

A central question in the fields of genetics and evolution was the nature and origin of spontaneous mutation. Bacterial genetic experiments throughout the middle of the 20th century were key to understanding how genomes change and what cellular mechanisms act to limit such change. These mechanisms are shared among all life on the planet and have implications for human diseases and aging. The purpose of this review is to highlight genetic breakthroughs during this period using bacterial systems...

Aging disrupts physiological and behavioral homeostasis, largely driven by one-carbon metabolism, mitochondrial, and metabolic imbalance. To elucidate the roles of conserved metabolic and mitochondrial genes in age-related decline, we employed genetic manipulations in vivo using Drosophila melanogaster models, in a cell-autonomous and non-cell-autonomous manner. By using panneuronal and indirect flight muscle (IFM) specific drivers, we assessed the impact of gene knockdown (KD) or overexpression...

Growth differentiation factor 15 (GDF15) and fibroblast growth factor 21 (FGF21) are stress-induced cytokines increased in age-related and metabolic disorders. The aim of the present study was to analyze the association between circulating concentrations of GDF15 and FGF21 in obesity and type 2 diabetes (T2D) in the context of aging. Serum samples from 405 participants (33 with normal weight and normoglycemia (NG), 156 with obesity and NG, 157 with obesity and impaired glucose tolerance (IGT),...

CONCLUSIONS: Significant heterogeneity exists in cognitive function among older adults with CMD, characterized by three distinct profiles. Varied transition patterns and probabilities underscore the importance of identifying and intervening with individuals at elevated risk of negative transitions, potentially improving their cognitive function.