Aging & Longevity

CD4 T cell therapy counteracts inflammaging and senescence by preserving gut barrier integrity

4 weeks 1 day ago
Healthy aging relies on a symbiotic host-microbiota relationship. The age-associated decline of the immune system can pose a threat to this delicate equilibrium. In this work, we investigated how the functional deterioration of T cells can affect host-microbiota symbiosis and gut barrier integrity and the implications of this deterioration for inflammaging, senescence, and health decline. Using the Tfam^(fl/fl)Cd4^(Cre) mouse model, we found that T cell failure compromised gut immunity leading...
Manuel M Gómez de Las Heras

Sensory Difficulty, Social and Physical Activity, and Dementia Risk Among Older Adults

4 weeks 1 day ago
ObjectivesSensory loss is associated with increased dementia risk, yet the underlying mechanisms remain unclear. This longitudinal study examined the association between self-reported sensory difficulty (vision, hearing, dual), social and physical activity, and dementia risk among older U.S. adults.MethodsData were drawn from the 2015-2020 National Health and Aging Trends Study (N = 6,295). Discrete-time survival mediation models with a structural equation modeling-based approach were estimated...
Shu Xu

Selective resilience in brain aging: challenging the scope of the disposable soma theory

4 weeks 1 day ago
The disposable soma theory (DST) posits that organisms prioritize reproductive success over long-term somatic maintenance, resulting in an inevitable decline after reproduction. However, such a basis does not fully explain the human brain's capacity to preserve metabolically costly, plastic, and cognitively essential functions well beyond the reproductive peak. This Perspective challenges the universality of DST by proposing that brain aging follows a selectively resilient trajectory, shaped by...
Bruno César Feltes

Synthetic torpor: advancing metabolic regulation for medical innovations

4 weeks 1 day ago
Torpor is a naturally occurring state of metabolic suppression that enables animals to adapt and survive extreme environmental conditions. Inspired by this adaptation, researchers have pursued synthetic torpor-an artificially induced, reversible hypometabolic state with transformative medical potential. Achieving synthetic torpor has been pursued for over a hundred years, with earlier work focused on identifying drugs for systemically suppressing metabolism. Breakthroughs in 2020 identified key...
Wenbo Wu

Heart Rate Dynamics During Localized Upper-Extremity Function as a Novel Measure of Cardiac Autonomic Dysfunction: Investigation of Aging- and Disease-Related Alterations

4 weeks 2 days ago
Introduction Cardiac autonomic dysfunction reduces the cardiac system's ability to respond to stressors and is prevalent in aging and diseases, especially cardiovascular diseases like aortic stenosis (AS). Heart rate variability (HRV) is a common measure for evaluating parasympathetic activity and cardiac autonomic function; similarly, heart rate (HR) changes during exercise are utilized in determining cardiac health. However, directly measuring HR parameters from an electrocardiogram (ECG) is...
Kübra Akbaş

Exercise as elixir to combat cardiovascular ageing

4 weeks 2 days ago
The global demographic shift towards an ageing population has rendered cardiovascular ageing and its associated pathologies a growing challenge for health. Emerging evidence highlights the critical role of exercise in mitigating age-associated cardiovascular alterations in structure and function and preventing ageing-associated cardiovascular diseases. However, the precise molecular mechanisms mediating these exercise-induced benefits in promoting healthy cardiovascular ageing remains...
Zihang Feng

Activation of a Src-JNK pathway in unscheduled endocycling cells of the Drosophila wing disc induces a chronic wounding response

4 weeks 2 days ago
The endocycle is a specialized cell cycle during which cells undergo repeated G/S phases to replicate DNA without division, leading to large polyploid cells. The transition from a mitotic cycle to an endocycle can be triggered by various stresses, which results in unscheduled, or induced endocycling cells (iECs). While iECs can be beneficial for wound healing, they can also be detrimental by impairing tissue growth or promoting cancer. However, the regulation of endocycling and its role in...
Yi-Ting Huang

Stress granule clearance mediated by V-ATPase-interacting protein NCOA7 mitigates ovarian aging

4 weeks 2 days ago
Reproductive longevity is essential for female fertility and healthy aging; however, the role of stress response, especially stress granule accumulation, in ovarian aging remains elusive and interventions are lacking. Here, we identified deleterious mutations and decreased expression of NCOA7, a stress-response protein related to granulosa cell senescence in women with physiological and pathological ovarian aging. NCOA7 deletion accelerates oxidative stress-related cellular senescence, ovarian...
Ting Dong

Comparison of the acute effects of breaking up prolonged sitting time with single-task or a dual-task walking on cognitive function and cerebral blood flow in older adults: a randomized crossover trial

4 weeks 2 days ago
This randomized cross-over study examined the acute effects of single-task or dual-task walking physical activity (PA) breaks of prolonged sitting among healthy older adults on cognitive performance and cerebral blood flow velocity (CBFv). Twenty-seven healthy older adults (69.4 ± 5.6 years, 25 female) were randomly assigned to engage in three experimental conditions (i.e., control, single-task, and dual-task walking), each one on a different day. All conditions included 3 h of sitting time,...
Paolo M Cunha

Understanding frailty in aging: a multidimensional perspective from Northern Iran

4 weeks 2 days ago
CONCLUSION: Frailty is highly prevalent among older adults in Sari and is associated with a complex interplay of demographic, socioeconomic, and health-related factors. Given the modifiable nature of certain risk factors, targeted interventions focusing on social support, financial stability, and physical activity are essential to mitigate frailty and enhance the quality of life in Iran's aging population.
Masoud Gharib

Altered translation elongation contributes to key hallmarks of aging in the killifish brain

4 weeks 2 days ago
Aging is a major risk factor for neurodegeneration and is characterized by diverse cellular and molecular hallmarks. To understand the origin of these hallmarks, we studied the effects of aging on the transcriptome, translatome, and proteome in the brain of short-lived killifish. We identified a cascade of events in which aberrant translation pausing led to altered abundance of proteins independently of transcriptional regulation. In particular, aging caused increased ribosome stalling and...
Domenico Di Fraia

Elevated ubiquitin phosphorylation by PINK1 contributes to proteasomal impairment and promotes neurodegeneration

4 weeks 2 days ago
Ubiquitin (Ub), a central regulator of protein turnover, can be phosphorylated by PINK1 (PTEN-induced putative kinase 1) to generate S65-phosphorylated ubiquitin (pUb). Elevated pUb levels have been observed in aged human brains and in Parkinson's disease, but the mechanistic link between pUb elevation and neurodegeneration remains unclear. Here, we demonstrate that pUb elevation is a common feature under neurodegenerative conditions, including Alzheimer's disease, aging, and ischemic injury. We...
Cong Chen

The social geography of fear and acceptance: an interview study on attitudes toward LGBQ identities in residential aged care

4 weeks 2 days ago
CONCLUSIONS: The study highlights that RAC is not only structured by formal policies but also co-created through everyday interactions among residents and staff. While previous research has emphasised the need for staff training and inclusive policies, these findings suggest that education alone may not be sufficient. This study argues that there may be value in establishing dedicated residential care facilities that are explicitly LGBTQ-friendly.
Klara Le

cTAGE5/MEA6 Regulates LBR Localization to Maintain Nuclear Envelope Integrity and Safeguard Against Aging

4 weeks 2 days ago
cTAGE5/MEA6 plays a pivotal role in COPII complex assembly, ER-to-Golgi trafficking, and secretion. However, whether cTAGE5/MEA6 is involved in other cellular functions remains unclear. Here, we show that conditional cTAGE5 knockout results in embryonic lethality during development and premature aging in adult mice. cTAGE5 deficiency leads to abnormal nuclear structure and disturbed cell proliferation in MEF cells. Further mechanistic studies reveal that cTAGE5 localizes not only to the ER exit...
Yaqing Wang

Development and validation of deep learning- and ensemble learning-based biological ages in the NHANES study

4 weeks 2 days ago
INTRODUCTION: Conventional machine learning (ML) approaches for constructing biological age (BA) have predominantly relied on blood-based markers, limiting their scope. This study aims to develop and validate novel ML-based BA models using a comprehensive set of clinical, behavioral, and socioeconomic factors and evaluate their predictive performance for mortality.
Yushu Huang

A human milk oligosaccharide alters the microbiome, circulating hormones, and metabolites in a randomized controlled trial of older adults

1 month ago
Aging-related immune dysfunction is linked to cancer, atherosclerosis, and neurodegenerative diseases. This 6-week randomized controlled trial evaluated whether 2'-fucosyllactose (2'-FL), a human breast milk oligosaccharide with established benefits in infants and animal models, could improve gut microbiota and immune function in 89 healthy older adults (mean age 67.3 years). While the primary endpoint of cytokine response change was not met, 2'-FL supplementation increased gut Bifidobacterium...
Matthew M Carter
Checked
2 hours 39 minutes ago
Aging and Longevity: Latest results from PubMed
Subscribe to Aging & Longevity feed