Aging & Longevity

The aging mouse CNS is protected by an autophagy-dependent microglia population promoted by IL-34

2 months 2 weeks ago
Microglia harness an unutilized health-promoting potential in age-related neurodegenerative and neuroinflammatory diseases, conditions like progressive multiple sclerosis (MS). Our research unveils an microglia population emerging in the cortical brain regions of aging mice, marked by ERK1/2, Akt, and AMPK phosphorylation patterns and a transcriptome indicative of activated autophagy - a process critical for cellular adaptability. By deleting the core autophagy gene Ulk1 in microglia, we reduce...
Rasmus Berglund

Drone-based displacement measurement of infrastructures utilizing phase information

2 months 2 weeks ago
Drone-based inspections provide an efficient and flexible approach to assessing aging infrastructures while prioritizing safety. Here, we present a pioneering framework that employs drone cameras for high-precision displacement measurement and achieves sub-millimeter accuracy, meeting the requirements for on-site inspections. Inspired by the principles of human auditory equilibrium, we have developed an effective scheme using a group of strategical reference markers on the bridge girders to...
Shien Ri

Scalable nano-architecture for stable near-blackbody solar absorption at high temperatures

2 months 2 weeks ago
Light trapping enhancement by nanostructures is ubiquitous in engineering applications, for example, in improving highly-efficient concentrating solar thermal (CST) technologies. However, most nano-engineered coatings and metasurfaces are not scalable to large surfaces ( > 100 m²) and are unstable at elevated temperatures ( > 850 ^(°)C), hindering their wide-spread adoption in CST. Here, we propose a scalable layer nano-architecture that can significantly enhance the solar absorption of an...
Yifan Guo

Gasdermin E dictates inflammatory responses by controlling the mode of neutrophil death

2 months 2 weeks ago
Both lytic and apoptotic cell death remove senescent and damaged cells in living organisms. However, they elicit contrasting pro- and anti-inflammatory responses, respectively. The precise cellular mechanism that governs the choice between these two modes of death remains incompletely understood. Here we identify Gasdermin E (GSDME) as a master switch for neutrophil lytic pyroptotic death. The tightly regulated GSDME cleavage and activation in aging neutrophils are mediated by proteinase-3 and...
Fengxia Ma

Spartin-mediated lipid transfer facilitates lipid droplet turnover

2 months 2 weeks ago
Lipid droplets (LDs) are organelles critical for energy storage and membrane lipid homeostasis, whose number and size are carefully regulated in response to cellular conditions. The molecular mechanisms underlying lipid droplet biogenesis and degradation, however, are not well understood. The Troyer syndrome protein spartin (SPG20) supports LD delivery to autophagosomes for turnover via lipophagy. Here, we characterize spartin as a lipid transfer protein whose transfer ability is required for LD...
Neng Wan

Climate migration amplifies demographic change and population aging

2 months 2 weeks ago
The warnings of potential climate migration first appeared in the scientific literature in the late 1970s when increased recognition that disintegrating ice sheets could drive people to migrate from coastal cities. Since that time, scientists have modeled potential climate migration without integrating other population processes, potentially obscuring the demographic amplification of this migration. Climate migration could amplify demographic change-enhancing migration to destinations and...
Mathew E Hauer

Accurate estimation of biological age and its application in disease prediction using a multimodal image Transformer system

2 months 2 weeks ago
Aging in an individual refers to the temporal change, mostly decline, in the body's ability to meet physiological demands. Biological age (BA) is a biomarker of chronological aging and can be used to stratify populations to predict certain age-related chronic diseases. BA can be predicted from biomedical features such as brain MRI, retinal, or facial images, but the inherent heterogeneity in the aging process limits the usefulness of BA predicted from individual body systems. In this paper, we...
Jinzhuo Wang

An acyl-CoA thioesterase is essential for the biosynthesis of a key dauer pheromone in C. elegans

2 months 3 weeks ago
Methyl ketone (MK)-ascarosides represent essential components of several pheromones in Caenorhabditis elegans, including the dauer pheromone, which triggers the stress-resistant dauer larval stage, and the male-attracting sex pheromone. Here, we identify an acyl-CoA thioesterase, ACOT-15, that is required for the biosynthesis of MK-ascarosides. We propose a model in which ACOT-15 hydrolyzes the β-keto acyl-CoA side chain of an ascaroside intermediate during β-oxidation, leading to...
Subhradeep Bhar

Hallmarks of stemness in mammalian tissues

2 months 3 weeks ago
All adult tissues experience wear and tear. Most tissues can compensate for cell loss through the activity of resident stem cells. Although the cellular maintenance strategies vary greatly between different adult (read: postnatal) tissues, the function of stem cells is best defined by their capacity to replace lost tissue through division. We discuss a set of six complementary hallmarks that are key enabling features of this basic function. These include longevity and self-renewal, multipotency,...
Joep Beumer

MENDER: fast and scalable tissue structure identification in spatial omics data

2 months 3 weeks ago
Tissue structure identification is a crucial task in spatial omics data analysis, for which increasingly complex models, such as Graph Neural Networks and Bayesian networks, are employed. However, whether increased model complexity can effectively lead to improved performance is a notable question in the field. Inspired by the consistent observation of cellular neighborhood structures across various spatial technologies, we propose Multi-range cEll coNtext DEciphereR (MENDER), for tissue...
Zhiyuan Yuan

Human trials exploring anti-aging medicines

2 months 3 weeks ago
Here, we summarize the current knowledge on eight promising drugs and natural compounds that have been tested in the clinic: metformin, NAD^(+) precursors, glucagon-like peptide-1 receptor agonists, TORC1 inhibitors, spermidine, senolytics, probiotics, and anti-inflammatories. Multiple clinical trials have commenced to evaluate the efficacy of such agents against age-associated diseases including diabetes, cardiovascular disease, cancer, and neurodegenerative diseases. There are reasonable...
Leonard Guarente

Association of exercise with pan-cancer incidence and overall survival

2 months 3 weeks ago
Lavery et al. show that the association between exercise and risk of cancer varied as a function of organ site and amount of exercise. Exercise was also associated with a longevity benefit regardless of a cancer diagnosis or not. This study further highlights the importance of exercise as an effective cancer preventive strategy.
Jessica A Lavery

Hormesis determines lifespan

2 months 3 weeks ago
This paper addresses how long lifespan can be extended via multiple interventions, such as dietary supplements [e.g., curcumin, resveratrol, sulforaphane, complex phytochemical mixtures (e.g., Moringa, Rhodiola)], pharmaceutical agents (e.g., metformin), caloric restriction, intermittent fasting, exercise and other activities. This evaluation was framed within the context of hormesis, a biphasic dose response with specific quantitative features describing the limits of biological/phenotypic...
Edward J Calabrese

Microphysiological systems for human aging research

2 months 3 weeks ago
Recent advances in microphysiological systems (MPS), also known as organs-on-a-chip (OoC), enable the recapitulation of more complex organ and tissue functions on a smaller scale in vitro. MPS therefore provide the potential to better understand human diseases and physiology. To date, numerous MPS platforms have been developed for various tissues and organs, including the heart, liver, kidney, blood vessels, muscle, and adipose tissue. However, only a few studies have explored using MPS...
Seungman Park

Fission-independent compartmentalization of mitochondria during budding yeast cell division

2 months 3 weeks ago
Lateral diffusion barriers compartmentalize membranes to generate polarity or asymmetrically partition membrane-associated macromolecules. Budding yeasts assemble such barriers in the endoplasmic reticulum (ER) and the outer nuclear envelope at the bud neck to retain aging factors in the mother cell and generate naïve and rejuvenated daughter cells. However, little is known about whether other organelles are similarly compartmentalized. Here, we show that the membranes of mitochondria are...
Saori R Yoshii

Screens in aging-relevant human ALS-motor neurons identify MAP4Ks as therapeutic targets for the disease

2 months 3 weeks ago
Effective therapeutics is much needed for amyotrophic lateral sclerosis (ALS), an adult-onset neurodegenerative disease mainly affecting motor neurons. By screening chemical compounds in human patient-derived and aging-relevant motor neurons, we identify a neuroprotective compound and show that MAP4Ks may serve as therapeutic targets for treating ALS. The lead compound broadly improves survival and function of motor neurons directly converted from human ALS patients. Mechanistically, it works as...
Meng-Lu Liu

Longevity interventions modulate mechanotransduction and extracellular matrix homeostasis in C. elegans

2 months 3 weeks ago
Dysfunctional extracellular matrices (ECM) contribute to aging and disease. Repairing dysfunctional ECM could potentially prevent age-related pathologies. Interventions promoting longevity also impact ECM gene expression. However, the role of ECM composition changes in healthy aging remains unclear. Here we perform proteomics and in-vivo monitoring to systematically investigate ECM composition (matreotype) during aging in C. elegans revealing three distinct collagen dynamics. Longevity...
Alina C Teuscher

FOXO1-mediated lipid metabolism maintains mammalian embryos in dormancy

2 months 3 weeks ago
Mammalian developmental timing is adjustable in vivo by preserving pre-implantation embryos in a dormant state called diapause. Inhibition of the growth regulator mTOR (mTORi) pauses mouse development in vitro, yet how embryonic dormancy is maintained is not known. Here we show that mouse embryos in diapause are sustained by using lipids as primary energy source. In vitro, supplementation of embryos with the metabolite L-carnitine balances lipid consumption, puts the embryos in deeper dormancy...
Vera A van der Weijden
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