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CONCLUSION: Active social interaction, regular participation in leisure activities, organized social activities, and informal social interactions are associated with more favourable health outcomes among older adults. Policies should prioritize supportive environments and age-friendly community renovations, while families and society should strengthen internal and external support systems to help foster active and healthy aging.

CONCLUSIONS: The receipt of financial support is greater among older adults with basic and instrumental functional disabilities. The association identified highlights the importance of public policies aimed at improving socioeconomic conditions and quality of life for older adults.

CONCLUSION: Low FA levels are strongly associated with increased risks of both objective and subjective negative outcomes. These findings highlight the importance of simultaneously considering IC and environment to properly explore FA in healthy aging.

CONCLUSION: An inverse linear association is observed between SWB and CVD risk among Chinese older adults. The strength of the association was greater in subgroups with more healthy lifestyles than that with less healthy lifestyles. Enhancing SWB and fostering more healthy lifestyle behaviors among older adults contributed to the prevention of CVD.

CONCLUSIONS: Participants described receiving care that was often not person- and family-centered despite this being a purported healthcare system value in Ontario, Canada. A cultural shift is thus needed in medical and social expectations of what it means to care for older adults.

CONCLUSION: Older adults with coexisting diabetes and heart disease experience accelerated declines in gait speed and hand grip strength compared with those with either condition alone or neither. These findings highlight the need for targeted functional monitoring and preventive interventions in this high-risk population, with particular attention given to sex, perceived health, and race-related disparities in physical aging.

CONCLUSION: This study revealed that ADL disability may partially mediate the relationship between depressive symptoms and cognitive function in older adults. Furthermore, the mediating effect of ADL disability was moderated by gender, and the effect was observed exclusively in males when analyzed hierarchically.

CONCLUSIONS: By providing a clear understanding of what an age-friendly hospital entails, our theoretical definition allows for a more systematic approach to evaluating and improving hospital facilities for older adults. The theoretical definition proposed in this paper can be used as a starting point for operationalizing the concept, which will facilitate the optimization of future age-friendly hospital standards and the development of empirical studies.

CONCLUSIONS: Our findings revealed that underweight BMI might be a predictor of low HGS in older adults, representing an important at-risk group for screening and intervention, and maintaining a higher BMI might prevent the development of low HGS in this population.

The molecular mechanisms underlying the pathogenesis of Alzheimer's disease (AD), the most common form of dementia, remain poorly understood. Proteomics offers a crucial approach to elucidating AD pathogenesis, as alterations in protein expression are more directly linked to phenotypic outcomes than changes at the genetic or transcriptomic level. In this study, we develop multiscale proteomic network models for AD by integrating large-scale matched proteomic and genetic data from brain regions...

Preclinical evidence suggests positive symptomatic and neuroprotective effects of hypoxic conditioning in Parkinson's disease (PD). This study (NCT05214287) investigated the safety, feasibility, short-term symptomatic and downstream effects of hypoxic conditioning in individuals with PD. 20 individuals with PD (mean age 62, 10 women, Hoehn-Yahr 1.5-3) completed randomized controlled double-blinded multiple N-of-1 trials. Each participant underwent five different 45-minute hypoxia interventions...

GBA is the major risk gene for Parkinson's disease (PD) and dementia with Lewy bodies (DLB), two common α-synucleinopathies with cognitive deficits. Here we investigate the role of mutant GBA in cognitive decline by utilizing Gba (L444P) mutant, SNCA transgenic (tg), and Gba-SNCA double mutant mice. Notably, Gba mutant mice show cognitive decline but lack PD-like motor deficits or α-synuclein pathology. Conversely, SNCA tg mice display age-related motor deficits, without cognitive abnormalities....

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The recent classification of the onset of turbulence as a directed percolation (DP) phase transition has been applied to all major shear flows including pipe, channel, Couette and boundary layer flows. A cornerstone of the DP analogy is the memoryless (Poisson) property of turbulent sites. We here show that, for the classic case of channel flow, neither the decay nor the proliferation of turbulent stripes is memoryless. As demonstrated by a standard analysis of the respective survival curves,...

Kininogen-1 (KNG1) is an important pro-inflammatory and pro-oxidant factor, but its precise role in skin aging remains inadequately elucidated. Quantitative 4D proteomic-sequencing analysis identified upregulated KNG1 in 3- and 15-month-old C57BL/6J mouse skin, with immunohistochemical staining corroborating its increase in intrinsic aging. KNG1 overexpression in murine skin reduced dermal thickness, collagen fibre content, elastic fibre density, aging marker Lamin B1, and increased oxidative...

Background and Objectives: With an aging population and growing economic hardship for many older adults, post-retirement work is increasingly common but often challenging due to complex, intersecting factors. This scoping review aims to identify key barriers and facilitators to post-retirement work. Methods: We searched APA PsycINFO, Embase, CINAHL, Scopus, and Web of Science for peer-reviewed studies (2000-2025) on post-retirement work among adults aged 50-80. Eligible studies underwent two...

In multiple sclerosis (MS), chronic compartmentalized inflammation is thought to drive relentless clinical deterioration. Here, we investigate the link between unresolved parenchymal inflammation and cellular senescence in MS progression. Single-cell transcriptomic analysis of human brain tissue reveals an accumulation of senescent-like glial cells in diseased white matter, especially in chronic active lesions, and to a lesser extent in the cortex. Spatial transcriptomics show gradients of...

Electrode corrosion and electrolyte decomposition in aqueous zinc-ion batteries (AZIBs) have significant impacts on their capacity, stability, and lifespan. Herein, a portable extended gate field-effect transistor (EGFET)-pH & dissolved oxygen (DO) sensor is constructed for in-situ monitoring of these adverse reactions in AZIBs. The EGFET-pH & DO sensor separates the sensitive electrodes from the detection circuitry, which gives the sensor high stability in aqueous solutions and enables its...

Aging affects multiple organs and within the brain drives distinct molecular changes across different cell types. The striatum encodes motor behaviors that decline with age, but our understanding of how cells within the striatum change remains incomplete. Using single-cell RNA sequencing from young and aged mice we identify molecularly distinct astrocyte subtypes. We show that astrocytes change significantly with age, exhibiting downregulation of genes, reduced diversity, and a shift to more...