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Stem cells reverse stroke damage and restore movement in mice

1 month 2 weeks ago
Stem cell transplants helped regenerate stroke-damaged brain tissue in mice, producing new neurons and restoring lost motor function. The treatment also improved blood vessels, inflammation, and the blood-brain barrier, raising hopes that a similar approach could eventually help repair the human brain after stroke.

Stopping Ozempic may raise heart attack and stroke risk

1 month 2 weeks ago
A large study suggests the cardiovascular benefits of GLP-1 drugs such as Ozempic, Wegovy, Mounjaro, and Zepbound can disappear surprisingly quickly when treatment stops. After two years off the medications, patients had a 22% higher risk of heart attack, stroke, and death compared with those who stayed on them.

Chronic stress may be quietly reshaping your heart

1 month 2 weeks ago
Chronic inflammation tied to stress, lifestyle, mental health, and socioeconomic conditions may silently change the heart for years before any symptoms appear. People with the highest inflammation levels faced a 43% greater risk of heart attack and stroke, raising hopes that earlier testing and anti-inflammatory treatments could help prevent serious heart disease.

A somatic checkpoint through NHR-49/HNF4alpha governs reproductive investment and longevity in C. elegans

1 month 2 weeks ago
The nuclear hormone receptor NHR-49, a homolog of mammalian PPARα and HNF4α, is a key transcriptional regulator of nutrition sensing and fatty acid metabolism in Caenorhabditis elegans. Here, we examine the role of NHR-49 in reproduction, including oocyte activation and ovulation. Loss of NHR-49 causes inappropriate oocyte activation and laying of unfertilized oocytes in the absence of sperm, resulting in rapid loss of yolk and stored fat, and drastic shortening of lifespan. Conversely,...
Sharada Gopal

RamanOmics decodes the spatial vibrational-molecular architecture of senescence in aging and repair

1 month 2 weeks ago
Aging and tissue repair involve heterogeneous remodeling across transcriptional, biochemical and cellular dimensions, yet prevailing definitions rely on isolated molecular markers that obscure how these states co-evolve. Here we present RamanOmics, a multimodal framework integrating label-free hyperspectral Raman imaging with single-nucleus RNA sequencing and spatial transcriptomics to link biochemical states with transcriptional programs at single-cell spatial resolution. Applied to young and...
Ke Zhang