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Exploring a crossroads in the aging process
Experiments on yeast show that the nuclear pore complex has a central role in the loss of chromosomes associated with aging.
Dissociation of the nuclear basket triggers chromosome loss in aging yeast
In many organisms, aging is a clear risk factor for chromosome missegregation, the main source of aneuploidy. Here, we report that old yeast cells lose chromosomes by partitioning them asymmetrically to their daughter cells together with the pre-existing (old) spindle pole body (SPB, centrosome equivalent in yeast). Strikingly, remodelling of the nuclear pore complex (NPC) and the displacement of its nuclear basket triggered these asymmetric chromosome segregation events. Simultaneously, nuclear...
Daily briefing: The bowhead whale’s secret to living to 200
Hotly debated dinosaur is not a tiny <i>T. rex</i> after all
<i>Nanotyrannus</i> and <i>Tyrannosaurus</i> coexisted at the close of the Cretaceous
Author Correction: Reciprocal signalling by Notch–Collagen V–CALCR retains muscle stem cells in their niche
Cleaning the scientific house: Rebuilding trust in science requires confronting the harms of ghostwriting
Science, Volume 390, Issue 6772, October 2025.
Porous materials: The next frontier in energy technologies
Science, Volume 390, Issue 6772, October 2025.
Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation
Science, Volume 390, Issue 6772, October 2025.
Conversion of syngas into olefins with high hydrogen atom economy
Science, Volume 390, Issue 6772, October 2025.
Structural dissection of αβ-tubulin heterodimer assembly and disassembly by human tubulin–specific chaperones
Science, Volume 390, Issue 6772, October 2025.
Electron accumulation across the perovskite layer enhances tandem solar cells with textured silicon
Science, Volume 390, Issue 6772, October 2025.
Global methane action pays for itself at least six times over
Science, Volume 390, Issue 6772, October 2025.
Diverse somatic genomic alterations in single neurons in chronic traumatic encephalopathy
Science, Volume 390, Issue 6772, October 2025.
FIGNL1 inhibits homologous recombination in BRCA2 deficient cells by dissociating RAD51 filaments
Science, Volume 390, Issue 6772, October 2025.
Can IVF save the northern white rhino from extinction? — October’s best science images
<i>T. rex</i> debate settled: contested fossils are smaller rival species, not juveniles
‘Teenage T. rex’ fossil is actually a different species
Experiments reveal extreme water generation during planet formation
In Science Journals
Science, Volume 390, Issue 6772, Page 485-487, October 2025.