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An ANGPTL8-AKT2-mTOR Axis Drives Adipose Senescence and Aging-Related Functional Decline
Adipose tissue senescence is increasingly recognized as a key driver of systemic aging and age-related functional decline, yet the endocrine regulators that actively promote this process remain poorly defined. Angiopoietin-like protein 8 (ANGPTL8) is a metabolic factor implicated in lipid metabolism and inflammation and has been associated with multiple aging-related disorders. However, its direct role in adipose tissue senescence and organismal aging remains unclear. Here, we identify ANGPTL8...
Daily briefing: Narcolepsy drug could kick off an Ozempic-style moment for the brain
First-of-its-kind narcolepsy drug opens door to new therapies for the brain
Why AI systems are most useful as designers of new scientific tools
Too hot to sleep? How heatwaves at night affect our health
Defect passivation and optical management of triple-junction solar cells
Author Correction: Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer
Programmable remodelling of carbon–nitrogen connectivity in amines
Positional isomerisation of pyridine via nitrogen transposition
Universities must stop protecting bullies — or more people will leave science
How the story of life and our planet unfolded — together
NIH plan to keep peer-review scores for grants secret draws concern
Under “binning” proposal, applications’ numerical ratings would no longer be used for final funding decisions
Justice Department calls three NSF diversity programs unconstitutional
New ruling bars programs said to discriminate by race and sex, six others can continue if modified
Massive new animal disease lab in Kansas runs into more delays
USDA doesn’t know when facility will be able to handle the most dangerous pathogens
A little-known protein may be fueling Alzheimer’s — and scientists found a way to block it
An experimental Alzheimer’s compound prevented damaging protein clumps from forming in the brains of mice, helping nerve cells survive longer and reducing amyloid buildup. The treatment also appeared to improve heart health and slow some signs of aging, raising hopes for an entirely new way to combat dementia.
This 10-cent heart drug cuts hospitalizations by 25%
A centuries-old heart drug costing less than ten cents a day could help keep heart-failure patients out of the hospital. New research suggests low-dose digoxin can reduce heart-failure hospitalizations by about 25%, potentially paving the way for its return as a major treatment.
A little movement in midlife could pay off for your brain years later
Exercise and healthy blood sugar levels in midlife may help slow cognitive decline decades later. Physical activity appeared especially beneficial for Mexican American adults, suggesting that some brain-protective factors may differ across populations.
The common mistake that could make aging joints hurt more
Aging gradually wears down the cartilage and fluid that protect our joints, but avoiding movement may actually make matters worse. Exercise helps nourish cartilage, strengthens the muscles that protect joints, and can reduce osteoarthritis pain. Low-impact activities such as swimming, cycling, tai chi, yoga, and walking on varied terrain may also improve balance and mobility. Even a few minutes of the right kind of movement can make a difference.
Aging's Competing Paradigms: Another Decade of Investigation into Damage-Driven versus Programmed Theories
The nature of aging remains debated: is it the accumulation of damage or by execution of a program? Here, we revisit this long-standing dichotomy in light of recent experimental advances, each one of us supporting one of those paradigms and being critical about the other. The damage-driven model views aging as the progressive loss of function caused by imperfect repair and modulated by factors such as rate of damage accumulation, damage resistance, biological redundancy, and tissue regeneration....
Sequalae and reversal of age-dependent alterations in mitochondrial dynamics via autophagy enhancement in reprogrammed human neurons
How aging of human neurons affects dynamics of essential organelle such as mitochondria and autophagosomes remains largely unknown. MicroRNA-induced directly reprogrammed neurons (miNs) derived from adult fibroblasts retain age-associated signatures of the donor, enabling the study of age-dependent features in human neurons, including longitudinal isogenic samples. Transcriptomic analysis revealed that neurons derived from elderly individuals are characterized by gene expression changes...