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Aging is characterized by the progressive deterioration of tissue structure and function, leading to increased vulnerability to diseases. Senescent cells (SCs) accumulate with age, but how the immune system regulates their burden is unclear. Here we show that CD4 T cells differentiate into Eomesodermin (Eomes)^(+)CCL5^(+) T lymphocytes (CD4-Eomes) in a SC-rich environment and that a reduction in the SC load, achieved using senolytic drugs, was sufficient to halt this differentiation. We further...

Reduced counterfactual ("What-If") thinking (CFT) in late life is believed to reflect successful adaptation to limited resources for overcoming missed opportunities, thereby preventing feelings of regret. We propose that this adaptation becomes critical from midlife onwards, affects emotional regulation, and is mediated by the preserved functionality of the ventromedial prefrontal cortex (vmPFC). To test this, an epidemiological sample from the Hamburg City Health Study (N = 494), aged 48 to 75,...

CONCLUSIONS: Our work reveals how tissue, sex, and age jointly govern the dynamics of the two cytosine modifications, augments the scope of DNA modification biomarker discovery, and provides a reference atlas to explore epigenetic dynamics in development and disease.

CONCLUSIONS: The PND was significantly associated with postoperative proBDNF and mBDNF.

CONCLUSIONS: The coexistence of diabetes and sarcopenic obesity synergistically increases cardiovascular disease risk beyond the effects of either condition alone in Chinese adults. These findings highlight the importance of comprehensive screening and integrated management strategies for individuals with both conditions to prevent cardiovascular complications.

CONCLUSIONS: Trying to delineate the unique molecular profile of older women and men becomes essential for understanding the mechanisms underlying the sex-frailty paradox. Further research on sex-specific determinants is required to enhance our understanding of aging and develop effective strategies to promote health and longevity in both sexes.

Autobiographical memory is essential for older adults, providing a foundation for self-identity. Although healthy aging is accompanied by changes in memory retrieval, musical memory remains relatively unaffected, suggesting music may serve as a cue for autobiographical memory recall. Autobiographically salient (ABS) music (i.e., deeply encoded songs associated with significant people, places, and events) is posited to engage distinct memory processes from familiar (FAM) music (i.e., songs that...

Single-cell multiomic technologies enable the joint analysis of different modalities, but face challenges due to experimental complexity. Current computational methods for single-cell cross-modality translation lack biological interpretability. Here, we present Cisformer, a cross-attention-based generative model tailored for cross-modality generation between gene expression and chromatin accessibility at single-cell resolution. Systematic benchmarking demonstrates the superior accuracy and...