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VMAT2 dysfunction impairs vesicular dopamine uptake, driving its oxidation and alpha-synuclein pathology in DJ-1-linked Parkinson's neurons
Parkinson's disease (PD) is characterized by α-synuclein accumulation and dopaminergic neuron degeneration, with dopamine (DA) oxidation emerging as a key pathological driver. However, the mechanisms underlying this neurotoxic process remain unclear. Using PD patient-derived and CRISPR-engineered induced pluripotent stem cell midbrain dopaminergic neurons lacking DJ-1, we identified defective sequestration of cytosolic DA into synaptic vesicles, which culminated in DA oxidation and α-synuclein...
Rare, dangerous side effects of some COVID-19 vaccines explained
“Groundbreaking” study uncovers why adenovirus-based shots caused life-threatening blood clots and bleeding in some people
Advances in the multifunctional roles of CX3CL1 in the central nervous system
C-X3-C motif chemokine ligand 1 (CX3CL1), a structurally unique chemokine in the central nervous system (CNS), shapes physiological and pathological processes via specific binding to its receptor, C-X3-C motif chemokine receptor 1 (CX3CR1). Empirical evidence indicates that this signaling axis exerts dual neuroinflammatory effects: It restrains microglial hyperactivation, yet can promote inflammation under conditions such as chronic stress. Notably, it preserves synaptic plasticity and...
Longitudinal Associations Between Neurodegenerative Biomarkers and Cognitive Decline in Older Adults: Insights From the LASI-DAD Study
CONCLUSIONS: Our findings suggest that biomarkers, including GFAP and NfL, are associated with cognitive decline over time in older adults in India. These biomarkers may serve as important indicators for monitoring cognitive aging and dementia risk in this population.
Negotiating Care and Risk in Thelma (2024)
In Thelma (2024), June Squibb sidesteps those who try to impose limitations on her and deftly commandeers available resources to exact revenge on a set of scammers.