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Daily briefing: Physics Nobel for quantum tunnelling on a macroscopic scale
These immune cells won Nobel fame — can they solve autoimmune disease?
The rise of ‘nightmare bacteria’: antimicrobial resistance in five charts
CD4 T cells acquire Eomesodermin to modulate cellular senescence and aging
Stop treating code like an afterthought: record, share and value it
The EU’s Horizon research fund needs to stay a defence-free zone
Customizable AI systems that anyone can adapt bring big opportunities — and even bigger risks
Groundbreaking quantum-tunnelling experiments win physics Nobel
Incentives accelerate progress on open access in Spain
Microbe discovery holds promise for sustainable biotechnology
The 1975 discovery of long-lost letters between Albert Einstein and the astronomer Willem de Sitter
Stop destructive fishing in marine protected areas
Insect biodiversity monitoring must be expanded
Prizes must recognize machine contributions to discovery
Quantum effects in electrical circuits honored with Physics Nobel
Breakthrough paved the way to many of today’s budding quantum computers
Missing wind from Milky Way’s giant black hole finally found
Astronomers may have glimpsed a long-predicted wind of gas blowing out from Sagittarius A*
Well-exercised male mice appear to pass fitness to their male offspring
Surprising epigenetic effect relies on snippets of RNA packaged within sperm
Effect of Origanum majorana tea on oxidative stress biomarkers in Parkinson's disease: a randomized placebo-controlled pilot study
CONCLUSION: Origanum majorana infusion may enhance or regulate antioxidant status and reduce oxidative damage in patients with PD. Further studies are warranted to explore its potential therapeutic benefits.
PARL stabilizes mitochondrial BCL-2 via Nur77-mediated scaffolding as a therapeutic strategy for Parkinson's disease
Parkinson's disease (PD) involves both mitochondrial dysfunction and Lewy body pathology. However molecular links between these features remain unclear. Here, we identify Presenilin-associated rhomboid-like protein (PARL) as a Lewy body component, RARL regulates mitochondrial apoptosis via interacting with orphan nuclear receptor Nur77. Clinical profiling revealed reduced plasma PARL levels in 71 PD patients versus controls (p < 0.001), which correlated with disease severity. In MPP^(+)/MPTP...
The CHCHD2-CHCHD10 protein complex is modulated by mitochondrial dysfunction and alters lipid homeostasis in the mouse brain
The highly conserved CHCHD2 and CHCHD10 are small mitochondrial proteins residing in the intermembrane space. Recently, mutations in the genes encoding these proteins have been linked to severe disorders, including Parkinson's disease and amyotrophic lateral sclerosis. In cultured cells, a small fraction of CHCHD2 and CHCHD10 oligomerize to form a high molecular weight complex of unknown function. Here, we generated a whole-body Chchd2 knockout mouse to investigate the in vivo role of CHCHD2 and...