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Longevity-promoting mitochondrial unfolded protein response activation requires elements of the PeBoW complex
Mitochondria play a crucial role in cellular energy metabolism and homeostasis and are strongly implicated in aging and age-related diseases. The outer mitochondrial membrane protein voltage-dependent anion channel (VDAC) plays multiple roles in mitochondrial homeostasis, including transport of metabolites, ATP, and Ca^(2+) Dysregulation of VDAC levels has been associated with cancer, neurodegeneration, metabolic disorders, and aging. Previously, we demonstrated that elevated VDAC-1 levels in...
Yttrium oxide engineered substrate enables improved durability for perovskite solar cells
Transparent conductive oxides (TCOs)-foundation of perovskite solar cells (PSCs)-have long been assumed to be stable, and thus their impact on device longevity is frequently overlooked. Herein, we unveil that fluorine doped tin oxide (FTO) suffers from instability under operational stress, exacerbating PSC stability issue. To address this issue, we propose a universal interface engineering strategy employing a scalable thermal evaporation followed by natural oxidation to form an atomically...
Value shift in response to aging: a longitudinal study based on healthy aging
CONCLUSION: By analyzing the structure, strength, and interaction path between IC and FA, research has found that diseases are just a process of FA development. However, the source variable - patient's IC - has received less attention. This suggests that policymakers should not only focus on identifying a disease, but also on assessing, maintaining, and providing intervention before the disease. The authorities should also promote the implementation of people-centered rather than...
Exploring effects of greenness and extreme heat exposure on hypertension incidence in elderly Chinese: a national cohort study
CONCLUSION: Green space mitigated the incidence of hypertension in older adults, particularly during extreme heat events. Urban greening could serve as a dual adaptation strategy against climate change and population aging.
Religious Attendance, Psychological Well-Being, and Mental Health Issues Among Older Adults: A Seven-Year Longitudinal Study in the United States
CONCLUSIONS: Hence, supporting older adults who wish to attend religious services may be linked to better psychological well-being and mental health.