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If AI discovers a drug, who gets the money?
Two intellectual property lawyers on why questions of AI inventorship and profit remain wide open
The relationship between metacognitive beliefs and healthy aging among older adults
No abstract
Excessive sleep duration increases the risk of dementia among older Chinese adults: evidence from the CLHLS
CONCLUSIONS: Overall, the present study findings demonstrate that excessive sleep duration (over 10 h) is an independent predictor of increased risk of dementia among older Chinese adults. Conversely, maintaining a moderate sleep duration of 6 to 8 h appears to be a protective factor, correlating with a lower incidence of the condition.
Dynamin-Related Protein 1-Dependent Disruption of Mitochondrial Homeostasis Drives Blue Light-Induced Epithelial-Mesenchymal Transition in Retinal Aging
Age-related macular degeneration (AMD) stands as a leading cause of blindness in the elderly, yet the fundamental aging processes that underpin its pathogenesis remain incompletely defined. The dysfunction of retinal pigment epithelial (RPE) cells is a central event in AMD, a process that shares key hallmarks with broader cellular aging, particularly the progressive decline in mitochondrial function. In this study, we investigated how a common environmental stressor-blue light-triggers a key...
Post-Stroke Depression and Activities of Daily Living: Sex-Differentiated Analysis of the Moderating Role of Physical Activity in Older European Adults
ObjectivesTo examine the mediating role of activities of daily living (ADL) in the association between stroke and depressive symptoms, and to investigate whether moderate physical activity (MPA) moderates this mediation in older adults, using sex-stratified analyses.MethodsCross-sectional data from 31,137 participants (≥65 years) were analysed using wave eight of the Survey of Health, Ageing and Retirement in Europe. Depression, ADL limitations, stroke history and weekly frequency of MPA were...
Daily briefing: The science influencers tackling misinformation online
Nanoscience is latest discipline to embrace large-scale replication efforts
Don’t deprioritize curiosity-driven research
Student dilemma: physical science or physical education?
Updates to the ‘bible’ for mental-health conditions will miss the mark — is it time to ditch the <i>DSM</i>?
The science influencers going viral on TikTok to fight misinformation
Why sky-high pay for AI researchers is bad for the future of science
Brain differences between sexes get more pronounced from puberty
What’s behind ‘teensplaining’? Scientists should study this adolescent behaviour
The funding system needs fixing — but it’s not a ‘waste of time and money’
Statistical approximation is not general intelligence
Smartphones are a double-edged tool in classrooms
Publisher Correction: Psychedelics elicit their effects by 5-HT2A receptor-mediated G<sub>i</sub> signalling
How do busy bees avoid overheating from flying?
New measurements could help predict pollinators’ ability to withstand climate change
A quantitative DOPA decarboxylase biomarker for diagnosis in Lewy body disorders
Accurate diagnosis of dementia with Lewy bodies (DLB) remains challenging, with misdiagnosis potentially leading to harmful treatment decisions. DOPA decarboxylase (DDC) shows promise as a cerebrospinal fluid (CSF) biomarker for DLB and Parkinson's disease (PD), but quantitative assays are needed for its clinical implementation. Here we report on the development of two DDC immunoassays and the extensive clinical validation of DDC across three clinical cohorts (n = 740), one biologically defined...