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Science, Volume 390, Issue 6775, Page 793-793, November 2025.

State-level mandates prompt changes and small acts of resistance at universities

Specialized hair cells pick electric currents induced by magnetism

Wave of mass brutality accompanied the collapse of the first pan-European culture

NASA-funded planetary science institute previously scrubbed hundreds of records from its archive

ObjectivesTo examine whether the association between vision and cognitive difficulties varies by age group.MethodsWe analyzed pooled data from the 2021-2023 National Health Interview Survey, including 52,582 U.S. adults aged 45 and older. Vision and cognitive difficulties were based on self-reports. Logistic regression with interaction terms assessed age-related differences.ResultsVision difficulty was reported by 22.7% of respondents. It was associated with over twice the odds of cognitive...

The gap between lifespan and healthspan is increasing globally, resulting in millions of individuals spending additional years burdened by frailty or disease. This disparity, paired with the increasingly aged populations of Western nations, poses a palpable predicament to public health and the economy. Deterioration of the skeletal muscle system is a key contributor to illness, loss of independence, and diminishing healthspan. Muscle quality correlates to longevity due to its significant role in...

Testosterone insufficiency disrupts spermatogenesis and expedites male aging. Autophagy facilitates testosterone synthesis. However, a molecular reduction mechanism of autophagy-related protein 4 homolog B (ATG4B) has not been established. Herein, we reveal that peroxiredoxin 1 (PRDX1) is clinically associated with male fertility disorders. Adult mutant mice with Leydig cell (LC)-specific deletion of the Prdx1 gene exhibit premature testicular aging and infertility. A series of in vivo and in...

For the last 140 years, the mechanisms of transport and dissipation of energy in a turbulent flow have not been completely understood. Previous research has focused on analyzing the so-called coherent structures, organized flow patterns characterized by their spatial coherence, lifespan and significant contribution to momentum and energy transfer. However, the connection between these structures and the flow development is still uncertain. Here, we show a data-driven methodology for objectively...

The lack of safe, durable therapeutics that act against both biological aging and Alzheimer's disease is an unmet clinical need. To bridge this gap, we devised an artificial intelligence (AI)-enabled approach that pairs rapid compound triage with mechanistic target deconvolution. Our AI-driven screening highlighted melatonin (MLT) as a promising candidate. Serum profiling of 161 human individuals confirmed an age-related fall in circulating MLT level, while subsequent in vivo and in vitro...

The lack of safe, durable therapeutics that act against both biological aging and Alzheimer's disease is an unmet clinical need. To bridge this gap, we devised an artificial intelligence (AI)-enabled approach that pairs rapid compound triage with mechanistic target deconvolution. Our AI-driven screening highlighted melatonin (MLT) as a promising candidate. Serum profiling of 161 human individuals confirmed an age-related fall in circulating MLT level, while subsequent in vivo and in vitro...

Understanding the complex relationships among major clinical outcomes and the interplay among multiple organs remains a considerable challenge. By using imaging phenotypes, we can characterize the functional and structural architecture of major human organs. Mendelian randomization (MR) provides a valuable framework for uncovering robust relationships between phenotypes by leveraging genetic variants as instrumental variables. Here we conduct a systematic multi-organ MR analysis involving 402...

Type 2 diabetes is an established risk factor for dementia. However, how its genetic heterogeneity affects different dementia subtypes remains unclear. In this study, we investigate the associations between genetic risk of type 2 diabetes and dementia subtypes among 33,136 older Chinese adults from the KARE cohort. We find that a higher overall polygenic risk score for type 2 diabetes is significantly associated with an increased risk of vascular dementia, but not Alzheimer's disease. Further...

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Researchers at Tibetan observatory trace gamma ray light back to violent microquasars

CONCLUSION: Overall, living in a damaged home was positively associated with increased PA and exercise levels, whereas the presence of a musty smell was linked to reduced PA and exercise levels among older adults. The observed sex differences suggest that interventions may need to be tailored accordingly. Our results underscore the importance of addressing home conditions, particularly damage and air quality, to promote PA among older adults.

CONCLUSIONS: This study revealed that depressive symptoms not only directly influenced cognitive impairment among older adults but also indirectly via proactive health. Exercise should be encouraged among the older people to promote their participation in social activities, thereby improving their proactive health and ultimately preventing cognitive impairment.

Macroautophagy/autophagy is a highly conserved pathway responsible for the bulk degradation of cytoplasmic material through the formation of a double-membrane structure known as the autophagosome. However, the precise mechanisms governing the transport of autophagosomes to the vacuole for degradation in plants remain largely elusive. There exists an ongoing debate about whether RAB7, a key regulatory protein, is involved in the plant autophagy pathway. In this study, we demonstrate that upon...

BACKGROUND: Population ageing increases frailty prevalence, a condition linked to higher disability risk. The Integrated Care for Older People (ICOPE) model promotes early frailty identification in primary care and integration of health, social, and community services. However, evidence of adaptations of ICOPE models in different contexts is scarce, as is knowledge of health literacy's (HL) role in frailty screening. This study protocol describes a project applying ICOPE indications to identify...

CONCLUSION: This study revealed that one-fourth of the study population had anaemia. The overall prevalence of anaemia was equal in males and females. The most common type of anaemia was the normocytic normochromic type and there was a significant association between anaemia and characteristics such as age, number of comorbidities and diabetes mellitus.