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Predicting the number of care beds for older people by a novel grey Verhulst cosine self-memory model: two case studies of Jiangsu and Shanghai, China
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Fasting and Caloric Restriction Activate an ADIOL-NHR-91-Kynurenine Pathway Signaling Axis to Promote Healthspan
The steroid hormone 5-androstene-3β,17β-diol (ADIOL) was discovered nearly a century ago in humans, yet its physiological functions have remained poorly understood. Using C. elegans, we identify ADIOL as essential for several pro-healthspan effects of fasting and caloric restriction (CR). These dietary restriction regimens activate an ADIOL-NHR-91-kynurenic acid signaling axis, partly through transcriptional programs associated with ADIOL biosynthesis. Within this axis, ADIOL acts through...
Senolytic Treatment With Fisetin Reverses Age-Related Endothelial Dysfunction Partially Mediated by SASP Factor CXCL12
Advancing age is the strongest risk factor for cardiovascular diseases (CVDs), primarily due to progressive vascular endothelial dysfunction. Cellular senescence and the senescence-associated secretory phenotype (SASP) contribute to age-related endothelial dysfunction by promoting mitochondrial oxidative stress and inflammation, which reduce nitric oxide (NO) bioavailability. However, the molecular changes in senescent endothelial cells (ECs) and their role in endothelial dysfunction with aging...
Brain Aging Mediating Heart Imaging-Derived Phenotypes and Mental and Nervous System Disorders
Mental and nervous system disorders often co-occur with cardiovascular diseases in aging populations, yet the biological relationships underlying these associations remain incompletely understood. Using heart and brain imaging data from 33,573 UK Biobank (UKB) participants, we developed a brain age prediction model to estimate the brain age gap (BAG), an imaging-based marker of brain aging. We then examined BAG as a mediator between 82 cardiac imaging-derived phenotypes (IDPs) and 11 disorders....
Beyond lifespan and healthspan: a biological framework for experienced longevity
Aging research has traditionally focused on lifespan and healthspan as primary outcome domains, implicitly treating chronological time as a uniform container of value. The memory-structured reconstruction of extended chronological intervals has not been systematically examined as an aging-related variable. I introduce experienced longevity, defined as the amount of lived time subjectively contained within a fixed chronological interval. Drawing on established distinctions between retrospective...
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Thousands of Harvard graduate students strike — bringing research to a halt
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We need to talk about failure in science
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Publisher Correction: Reproducibility and robustness of economics and political science research
How your heartbeat could keep cancer at bay
Field re-entrant superconductivity in Eu-doped infinite-layer nickelates
The impact of epigenetics on health and disability
Science, Volume 392, Issue 6796, April 2026.
Molecular solar thermal energy storage in Dewar pyrimidone beyond 1.6 megajoules per kilogram
Science, Volume 392, Issue 6796, April 2026.
Molecular and cellular processes disrupted in the early postnatal Down syndrome prefrontal cortex
Science, Volume 392, Issue 6796, April 2026.
A single-cell multiomic analysis identifies molecular and gene-regulatory mechanisms dysregulated in developing Down syndrome neocortex
Science, Volume 392, Issue 6796, April 2026.
An unrecognized mode of small particles in the lower stratosphere
Science, Volume 392, Issue 6796, April 2026.