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Cities aren’t built for women — it’s time to change that
Wooden skyscrapers point the way to more sustainable cities
AI reviewers are here — we are not ready
Geothermal networks let cities warm and cool as one
A bothy among the stars
China accounts for more than half of leading output in the applied sciences
Cities are embracing nature for flood defence
Data drive city transportation forwards
‘Anyone hired a student before?’ How a group of novice lab leaders are supporting each other
Darleane C. Hoffman obituary: chemist who expanded the periodic table
Growing cities face mounting challenges
Author Correction: Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis
Author Correction: Seismic detection of a 600-km solid inner core in Mars
Retraction Note: The economic commitment of climate change
The ‘silent’ brain cells that shape our behaviour, memory and health
Watch this tiny robot somersault through the air like an insect
Device weighing less than a paperclip is faster and more agile than its predecessors
To boost research, states are building their own AI-ready supercomputers
New York aims to democratize access to hardware often limited to federal labs and Big Tech
Clonal persistence dominates homeostatic intestinal IgA responses
Immunoglobulin A (IgA) is the most abundantly produced antibody isotype and mediates protection and homeostatic regulation at mucosal surfaces. Steady-state IgA production is supported by multiple pathways, including chronic germinal centers in gut inductive lymphoid tissues. However, we lack a detailed understanding of how IgA responses are temporally integrated across inductive and effector sites. Here, we dissect homeostatic IgA responses from the perspective of clonal repertoires in...
Attenuation of ATM signaling by ROS delays replicative senescence at physiological oxygen
Replicative senescence is a powerful tumor suppressor pathway that curbs proliferation of human cells when a few critically-short telomeres activate the DNA damage response (DDR). We show that ATM is the sole DDR kinase responsible for the induction and maintenance of replicative senescence and that ATM inhibition can induce normal cell divisions in senescent cells. Compared to non-physiological atmospheric (∼20%) oxygen, primary fibroblast cells grown at physiological (3%) oxygen were more...
Epigenome-wide association study of nuclear DNA methylation in relation to mitochondrial heteroplasmy
We analyze 10,986 participants (mean age 77; 63% women; 54% non-White) across seven U.S. cohorts to study the relationship between mitochondrial DNA (mtDNA) heteroplasmy and nuclear DNA methylation. We identify 597 CpGs associated with heteroplasmy burden, generally showing lower methylation. These CpGs are enriched in dynamically regulated island shores and depleted in CpG islands, indicating involvement in context-specific rather than constitutive gene regulation. In HEK293T cells, we...