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Rewiring an olfactory circuit by altering cell-surface combinatorial code
Electro-generated excitons for tunable lanthanide electroluminescence
Hepatic zonation determines tumorigenic potential of mutant β-catenin
Integrator dynamics in the cortico-basal ganglia loop for flexible motor timing
Tumour-reactive heterotypic CD8 T cell clusters from clinical samples
Structural basis of regulated N-glycosylation at the secretory translocon
Repulsions instruct synaptic partner matching in an olfactory circuit
Semantic design of functional de novo genes from a genomic language model
ZAK activation at the collided ribosome
Prime editing-installed suppressor tRNAs for disease-agnostic genome editing
Connectivity underlying motor cortex activity during goal-directed behaviour
Insulin cream offers needle-free option for diabetes
Author Correction: AIM2 in regulatory T cells restrains autoimmune diseases
The Asymmetric Synthesis of an Acyclic <i>N</i>-Stereogenic Amine
Author Correction: A metallic <i>p</i>-wave magnet with commensurate spin helix
Watch superstretchy bloodworms turn themselves inside out
The marine worm’s unusually structured proboscis could inspire future soft-bodied robots
Despite Trump chaos, NSF avoided feared dip in research financing
Number of new grants fell by 20%, but got larger, as funder braced for potential budget cut
Alterations in cortical sulcal morphology in Parkinson's disease patients with impulse control disorders
Impulse control disorders, debilitating non-motor complications of Parkinson's disease, are linked to dopaminergic therapy and mesocorticolimbic dysfunction. This study aimed to characterize cortical sulcal depth, a sensitive morphometric index of cortical folding, and cortical thickness and subcortical volumetric alterations in Parkinson's disease patients with impulse control disorders. Sixty-eight Parkinson's disease patients (30 with impulse control disorders, 38 without impulse control...
Frailty and the brain: A narrative review of functional and pathological correlates
Frailty influences the risk, phenotypic expression, and course of highly prevalent neurological conditions. However, the structural, functional, and pathological changes in the brain associated with frailty remain insufficiently explored. This narrative review examines existing evidence on the functional and pathological brain correlates of frailty in both healthy adults and patients with neurological conditions, encompassing findings from neuropathology, fluid biomarkers, neuroimaging, and...
Spinal cord Tau pathology induces tactile deficits and cognitive impairment in Alzheimer's disease via dysregulation of CCK neurons
Somatosensory processing has been shown to be correlated with brain development and cognitive function, but whether and how tactile sensory deficits affect cognition decline remains unclear. Here we show that tactile function is impaired in individuals with Alzheimer's disease (AD), and this impairment is inversely correlated with Montreal Cognitive Assessment scores and positively correlated with Tau pathology. We observed similar deficits in presymptomatic 3×Tg AD mice and find that...