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This is the world’s largest spider web — November’s best science images
Bulk superconductivity up to 96 K in pressurized nickelate single crystals
Why universities need to radically rethink exams in the age of AI
Great science happens in great teams — research assessments must try to capture that
Don’t downplay problems of bullying and harassment in academia
Towns lag behind the switch to standard time
Alternatives to animal research are not inherently more ethical
‘Fire amoeba’ survives in hotter conditions than any other complex cell
Drinking water is at risk during warfare — better protections are needed
Ease the EU postdoc job market with better routes to innovation
Memes reveal threats to graduate-student mental health
Author Correction: The first-principles phase diagram of monolayer nanoconfined water
Author Correction: Video‐rate tunable colour electronic paper with human resolution
Proteogenomics uncovers biological fingerprints of small vessel disease
Will blockbuster obesity drugs revolutionize addiction treatment?
As Energy Department prioritizes AI and fusion, basic research faces squeeze
Reorganization could shift mission of the United States’s largest funder of the physical sciences
Brain’s ‘plumbing’ inspires new Alzheimer’s strategies—and controversial surgeries
Animal studies support idea that boosting fluid clearance could blunt neurological disorders
Cognitive impairment among older adults in India: understanding the role of substance use and lifestyle factors
CONCLUSIONS: Substance use and other lifestyle factors are significantly associated with cognitive impairment among the older adults in India. Therefore, encouraging older adults who use tobacco or alcohol to assess their cognitive function at an earlier stage that could prevent or mitigate cognitive impairment, thereby enhancing their quality of life. This contribute to achieve of Sustainable Development Goals, particularly Goal 3 that guaranteeing good health and wellbeing for all.
A nanoMIP sensor for real-time in vivo monitoring of levodopa pharmacokinetics in precision Parkinson's therapy
Real-time in vivo monitoring of levodopa pharmacokinetics is essential to address its narrow therapeutic window in Parkinson's disease (PD) therapy. However, current methods require excessive sample volumes, suffer low sampling frequencies, and fail to capture complete pharmacokinetic profiles. Here, we present an in vivo monitoring system for real-time tracking of levodopa levels in interstitial fluid (ISF) using a spindle-shaped carbon nanotube (CNT) fiber electrochemical sensor functionalized...
Molecular mechanism of PINK1 regulation by the Hsp90 machinery
Hundreds of human kinases, including PINK1-a protein kinase associated with familial Parkinson's disease-are regulated by Hsp90 and its cochaperones. While previous studies have elucidated the mechanism of kinase loading into the Hsp90 machinery, the subsequent regulation of kinases by Hsp90 and its cochaperones remains poorly understood. In this study, using complexes obtained through PINK1 pulldown, we determine the cryo-EM structures of the human Hsp90-Cdc37-PINK1 complex at 2.84 Å,...