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Longevity-promoting mitochondrial unfolded protein response activation requires elements of the PeBoW complex

1 month 3 weeks ago
Mitochondria play a crucial role in cellular energy metabolism and homeostasis and are strongly implicated in aging and age-related diseases. The outer mitochondrial membrane protein voltage-dependent anion channel (VDAC) plays multiple roles in mitochondrial homeostasis, including transport of metabolites, ATP, and Ca^(2+) Dysregulation of VDAC levels has been associated with cancer, neurodegeneration, metabolic disorders, and aging. Previously, we demonstrated that elevated VDAC-1 levels in...
Adebanjo Adedoja

Yttrium oxide engineered substrate enables improved durability for perovskite solar cells

1 month 3 weeks ago
Transparent conductive oxides (TCOs)-foundation of perovskite solar cells (PSCs)-have long been assumed to be stable, and thus their impact on device longevity is frequently overlooked. Herein, we unveil that fluorine doped tin oxide (FTO) suffers from instability under operational stress, exacerbating PSC stability issue. To address this issue, we propose a universal interface engineering strategy employing a scalable thermal evaporation followed by natural oxidation to form an atomically...
Haibing Wang

Value shift in response to aging: a longitudinal study based on healthy aging

1 month 3 weeks ago
CONCLUSION: By analyzing the structure, strength, and interaction path between IC and FA, research has found that diseases are just a process of FA development. However, the source variable - patient's IC - has received less attention. This suggests that policymakers should not only focus on identifying a disease, but also on assessing, maintaining, and providing intervention before the disease. The authorities should also promote the implementation of people-centered rather than...
Yiran Shen