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A sensory system for mating in octopus

1 month 3 weeks ago
Science, Volume 392, Issue 6793, Page 96-101, April 2026.
Pablo S. Villar, Hao Jiang, Tatiana Shugaeva, Emma L. Berdan, Arpita Kulkarni, Makoto Hiroi, Giovanni Masucci, Sam Reiter, Erik Lindahl, Rebecca J. Howard, Ryan E. Hibbs, Nicholas W. Bellono

Atomic-resolution imaging of gold species at organic liquid-solid interfaces

1 month 3 weeks ago
Science, Volume 392, Issue 6793, Page 77-82, April 2026.
Sam Sullivan-Allsop, Nick Clark, Wendong Wang, Rongsheng Cai, William Thornley, David G. Hopkinson, James G. McHugh, Ben Davies, Samuel Pattisson, Nicholas F. Dummer, Rui Zhang, Matthew Lindley, Gareth Tainton, Jack Harrison, Hugo De Latour, Joseph…

Pearling drives mitochondrial DNA nucleoid distribution

1 month 3 weeks ago
Science, Volume 392, Issue 6793, Page 102-109, April 2026.
Juan C. Landoni, Matthew D. Lycas, Josefa Macuada, Willi Stepp, Roméo Jaccard, Christopher J. Obara, Andrew S. Moore, David Hoffman, Jennifer Lippincott-Schwartz, Wallace Marshall, Gabriel Sturm, Suliana Manley

Young blood

1 month 3 weeks ago
Science, Volume 392, Issue 6793, Page 34-34, April 2026.
H. Holden Thorp

TNF alpha unmasks enteric malate aspartate shuttle dysfunction bridging Parkinson disease and intestinal inflammation

1 month 3 weeks ago
Gastrointestinal dysfunction often precedes motor symptoms in Parkinson's disease (PD), suggesting the enteric nervous system (ENS) is central to early pathogenesis. How α-synuclein contributes to ENS dysfunction, and how inflammation modulates this, remains unclear. Here we show that Tumor Necrosis Factor alpha enhances α-synuclein accumulation in induced pluripotent stem cell-derived enteric neurons and glia, and impairs the malate-aspartate shuttle, a key pathway for mitochondrial energy...
Bruno Ghirotto

Therapy-induced senescent cancer cells as bidirectional regulators of antitumor immunity and resistance in the tumor microenvironment

1 month 3 weeks ago
Cancer immunotherapy has markedly improved patient outcomes, particularly when combined with conventional treatments such as chemotherapy, radiotherapy, and targeted therapy. Following these therapies, however, a subset of cancer cells can enter a senescent state, ceasing proliferation while remaining metabolically active and persistent within tissues. Such therapy-induced senescent cancer cells (TISCCs) significantly influence antitumor immune responses. TISCCs can enhance tumor immunogenicity...
Minji Choi