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IL-1alpha in aging tumors
No abstract
Editorial: Model organisms in neuroinflammation and neuropathy: <em>Drosophila melanogaster</em>
No abstract
Daily briefing: Avatar therapy helps people with psychosis stand up to the voices in their heads
How we pivoted to studying Ukrainian researchers during the war
The US election is monumental for science, say <i>Nature</i> readers — here’s why
Hidden wonders: laser data reveal a dense network of ancient Maya settlements
Civil engineer Herbert Stone’s rock-solid views on Stonehenge
Why forecast an election that’s too close to call?
How to spend one trillion dollars: the US decarbonization conundrum
‘Educational’ apps are worth billions. We need to make sure they work
Fathers disadvantaged by European research-grant policy
Sustainability in the lab: funders and researchers should sign up and partner up
Prestigious Japanese biomedical awards need to become more gender-representative
European hedgehog’s ‘near threatened’ listing raises concerns for an iconic species
New Alzheimer’s drugs create prescribing dilemmas for doctors
As monoclonal antibodies roll out, uncertainty about their risks and benefits is dividing physicians
Key global bioethics guidelines get ‘dramatic’ update
Revised Declaration of Helsinki stresses need for equity, protection of vulnerable groups, and research integrity
Tight House race in Pennsylvania could affect federal science spending
The top Democrat on a congressional panel that oversees several research agencies faces a Trump-backed newcomer
The reconstruction of evolutionary dynamics of processed pseudogenes indicates deep silencing of "retrobiome" in naked mole rat
Approximately half of mammalian genomes are occupied by retrotransposons, highly repetitive interspersed genetic elements expanded through the mechanism of reverse transcription. The evolution of this "retrobiome" involved a series of explosive amplifications, presumably associated with high mutation rates, interspersed with periods of silencing. A by-product of retrotransposon activity is the formation of processed pseudogenes (PPGs)-intron-less, promoter-less DNA copies of messenger RNA...
Chronic polypharmacy, monotherapy, and deprescribing: Understanding complex effects on the hepatic proteome of aging mice
Polypharmacy (use of ≥5 concurrent medications) is highly prevalent among older adults to manage chronic diseases and is linked to adverse geriatric outcomes, including physical and cognitive functional impairments, falls, frailty, hospitalization, and mortality. Deprescribing (withdrawal) is a potential strategy to manage polypharmacy. The broad molecular changes by which polypharmacy causes harm and deprescribing may be beneficial are unknown and unfeasible to study rigorously in tissue from...
Aging alters the effect of adiponectin receptor signaling on bone marrow-derived mesenchymal stem cells
Adiponectin receptor signaling represents a promising therapeutic target for age-related conditions such as osteoporosis and diabetes. However, the literature presents conflicting evidence regarding the role of adiponectin signaling in bone homeostasis and fracture repair across different health states, ages, and disease conditions. These inconsistencies may arise from the complex endocrine and paracrine feedback mechanisms regulating adiponectin, as well as the variability in adiponectin...