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Daily briefing: How to brew a climate-friendly coffee
Therapeutic inhibition of telomeric DNA damage response rescues hematopoietic dysfunction driven by telomere shortening and aging
Inhibition of telomere damage signaling restores hematopoiesis and immune function
Early television set impresses Nature editors — but will it catch on?
Enhanced B cell priming induces broadly neutralizing HIV-1 apex antibodies
Retraction Note: NSD2 targeting reverses plasticity and drug resistance in prostate cancer
Vaccination elicits HIV broadly neutralizing antibodies in primates
Coffee is under threat: how scientists are fighting to save it from extinction
AI systems devise hypotheses and ways to test them
Can Rwanda sustain its rise in science and technology? Here’s what can help
AI tools can speed up thinking, but evidence still comes from the lab bench
Ebola preparedness must start with ecosystems and before humans show symptoms
Child online safety needs more than social-media bans
New calculator reveals whether you should really worry about statin side effects
Scientists at the University of Oxford have created a calculator that predicts a person's individual risk of serious muscle disorders from statin medications. Their analysis found that more than 98% of people who qualify for statins are at low risk for these rare complications, despite widespread concerns about side effects. The study also revealed that most eligible patients are not taking statins, potentially missing important protection against heart attacks and strokes.
Scientists say creatine may help fight depression
Creatine is best known as a muscle-building supplement, but scientists are now investigating whether it could also help treat depression by boosting the brain's energy supply. A new review examined five randomized clinical trials involving 238 participants and found mixed results. Two studies, both involving women with major depressive disorder, reported that adding creatine to standard treatment improved symptoms, while three others found no meaningful benefit.
Provision buried in controversial U.S. rule change would help people legally challenge ‘woke’ federal research
White House asserts expanded authority to prosecute any wasteful spending “in the national interest”
USC scientists just unlocked an endless supply of cancer-fighting immune cells
A new stem-cell-inspired technique allows scientists to grow vast numbers of immune-cell progenitors that can be engineered to hunt cancer and strengthen immune responses. In animal studies, the cells fought tumors, restored immune function, and showed promise as a durable, off-the-shelf therapy platform.
Scientists discover an unexpected way to make pancreatic cancer cells self-destruct
Researchers tested experimental PCAI compounds against pancreatic cancer cells and found they had powerful anticancer effects. One leading compound blocked more than 90% of cancer cell migration, suggesting it could help prevent the spread of tumors. Rather than suppressing cancer signaling, the treatment hyperactivated key pathways until the cells essentially self-destructed.
A native sulfur deposit in Gale crater, Mars
Science, Ahead of Print.
Arc mediates intercellular tau transmission via extracellular vesicles
Tau pathology spreads cell to cell, but the mechanisms of intercellular tau transmission remain unclear. We find that the neuronal gene Arc is critical for the release of tau in neuronal extracellular vesicles (EVs) via a direct protein-protein interaction. Brain EVs purified from transgenic rTg4510 mutant tau mice (rTg^(WT)) crossed with Arc knockout mice (rTg^(Arc KO)) contain less tau and reduced tau seeding potential. Both Arc and tau are co-packaged in mouse and human brain-derived EVs....