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Genome-wide association study of frailty and integrative functional analysis to elucidate its relationship with aging
Frailty is a clinically recognizable condition of vulnerability with aging, leading to adverse health outcomes. Previous GWASs on frailty have identified 59 susceptibility loci, although the underlying mechanisms remain unclear. We investigated the genetic determinants of frailty and biological relationship between frailty and aging genes in 14,664 middle-aged and elderly Korean participants. We performed cohort-based (KoGES and KNHANES) meta-analysis of GWAS and candidate gene approach focusing...
Computerized cognitive training on touchscreen for elderly: a systematic review of randomised controlled trials
An aging global population requires preventive and curative interventions to address cognitive decline. Touchscreen computerized cognitive training provides an engaging, portable, cost-effective, and accessible solution for seniors. We conducted a systematic review of randomized controlled trials (RCTs) to determine, using meta-analysis, the effects of computerized cognitive training on older adults using touchscreens. We conducted a literature review to identify RCTs involving older adults in...
Population-Based Structural Evidence: Triadic Effects of Periodontitis, Depression, and Biological Aging on Cognitive Health
CONCLUSIONS: This confirms triadic interdependencies where biological aging partially mediates periodontitis/depression effects on cognition. Prioritizing periodontal care and mental health may mitigate cognitive decline, especially in low-resource settings.