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Longevity steps on the cGAS

1 month 3 weeks ago
Science, Volume 390, Issue 6769, Page 126-127, October 2025.
John C. Martinez, Andrei Seluanov, and Vera Gorbunova

In Other Journals

1 month 3 weeks ago
Science, Volume 390, Issue 6769, Page 142-143, October 2025.
Corinne Simonti, and Jesse Smith, Sacha Vignieri, Ekeoma Uzogara, Mattia Maroso, Madeleine Seale, Ian S. Osborne, Jelena Stajic, and Jack Huang

AMPKα2 signals amino acid insufficiency to inhibit protein synthesis

1 month 3 weeks ago
The functional difference between the two catalytic subunits, α1 and α2, of AMP-activated protein kinase (AMPK) complexes remains elusive. Herein, we report that AMPKα2 specifically transduces amino acid insufficiency signals to protein synthesis. Low amino acid levels, high protein levels, and reduced phosphorylation of AMPKα threonine 172 (p-T172) are observed in blood samples in patients with Alzheimer's disease (AD) from a cohort of 1,000,000 Chinese individuals. Loss of α2, but not α1,...
Yunzi Mao