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Construction of complex and diverse DNA sequences using DNA three-way junctions
Afar fossil shows broad distribution and versatility of <i>Paranthropus</i>
ADHD is on the rise, but why?
The biggest ‘Schrödinger’s cat’ yet — physicists put 7,000 atoms in superposition
Publisher Correction: Polyamine-dependent metabolic shielding regulates alternative splicing
Publisher Correction: Multiple oestradiol functions inhibit ferroptosis and acute kidney injury
Editorial Expression of Concern: The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM
Girls are starting puberty younger — why, and what are the risks?
Seven technologies to watch in 2026
AI and nuclear energy feature strongly in agenda-setting technologies for 2026
The rich stopped buying yachts the year time went on sale
Trove of Mexican genomes could help guide prescribing decisions
Study reveals role of “fine-grained” ancestry in predicting response to painkillers, statins, and other drugs
Spacecraft captures a solar flare as it builds into an explosive outburst
Europe’s Solar Orbiter is helping researchers understand what causes the Sun to blast out radiation and particles
Bizarre 400-million-year-old fossil was an unknown life form
Enigmatic organism known as Prototaxites cannot be fungus, new analysis finds
In the age of Trump, are U.S. scientists ‘bringing white papers to a gunfight’?
An unprecedented assault has forced researchers to rethink their advocacy tactics
Ice age Europeans imported tools from distant lands, perhaps as souvenirs
Mementos may have reinforced vast social networks during turbulent times
Enhancing link prediction in biomedical knowledge graphs with BioPathNet
Understanding complex interactions in biomedical networks is crucial for advancements in biomedicine, but traditional link prediction (LP) methods are limited in capturing this complexity. We present BioPathNet, a graph neural network framework based on the neural Bellman-Ford network (NBFNet), addressing limitations of traditional representation-based learning methods through path-based reasoning for LP in biomedical knowledge graphs. Unlike node-embedding frameworks, BioPathNet learns...
Proteolysis-targeting chimera (PROTAC): a promising senolytic strategy
Senescent cells (SCs) accumulate with aging and contribute to the development of age-related pathologies. These cells evade apoptosis through upregulation of senescent cell anti-apoptotic pathways (SCAPs), making their selective elimination, a strategy termed senolysis, a promising therapeutic avenue. Proteolysis-targeting chimeras (PROTACs) represent an emerging class of bifunctional molecules that exploit the ubiquitin-proteasome system to degrade specific target proteins. By concurrently...
Behavioral and psychophysical characterization of proprioceptive impairment in healthy aging: a hyper-illusory experience of movement
Age-related deterioration of the sensorimotor system can impair proprioception. This study aimed to characterize age-related changes in the sense of position and movement. Three experiments involved two groups of participants (29 young adults and 26 older adults) to i) evaluate the performance in a position matching task (Experiment 1), ii) assess the perception and reproduction of an illusory movement evoked by proprioceptive stimulation (mechanical muscle-tendon vibration) (Experiment 2), and...
Early-onset Palmijihwang-hwan treatment modulates phospholipid metabolism and gut microbiota for healthy aging: reducing adipose inflammation and oxidative stress
Aging is characterized by progressive physiological decline and increased vulnerability to metabolic and inflammatory disturbances. Palmijihwang-hwan (PM), a traditional East Asian herbal formula, has been used empirically for age-related complaints, but its mechanistic basis remains unclear. Here, we evaluated the effects of early-onset PM administration (starting at 2 months of age) on longevity-related phenotypes and metabolic regulation. PM significantly prolonged lifespan in Caenorhabditis...