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Bullied in science: I quit my job and launched an advocacy non-profit
Bring PhD assessment into the twenty-first century
How OpenAI’s text-to-video tool Sora could change science – and society
Embrace AI to break down barriers in publishing for people who aren’t fluent in English
Pay for trees with carbon credits to deliver urban green spaces for all
Water shortages means greening southern European cities won’t be easy
From the archive: Brain–body connection, and cuttlefish ink distracts predators
On the ethics of informed consent in genetic data collected before 1997
Biden seeks to boost science funding — but his budget faces an ominous future
China–US climate collaboration concerns as Xie and Kerry step down
Ladybug becomes powerful foe after ‘stealing’ toxins from invasive insect
Despite having no history of coevolution, Australian beetles in Spain can store and use defensive chemicals from an invasive American species
Jupiter’s ocean moon may be dead inside
Long heralded as a promising place to look for life, Europa’s sea floor may be geologically inert
Flirting female frogs blink to beckon potential princes
The behavior, once thought to be unique to primates, appears to serve as an amphibian social signal
Articular cartilage corefucosylation regulates tissue resilience in osteoarthritis
This study aimed to investigate the glycan structural changes that occur before histological degeneration in osteoarthritis (OA) and to determine the mechanism by which these glycan conformational changes affect cartilage degeneration. An OA model was established in rabbits using mannosidase injection, which reduced high-mannose type N-glycans and led to cartilage degeneration. Further analysis of glycome in human OA cartilage identified specific corefucosylated N-glycan expression patterns....
Higher total energy costs strain the elderly, especially low-income, across 31 developed countries
Addressing the total energy cost burden of elderly people is essential for designing equitable and effective energy policies, especially in responding to energy crisis in an aging society. It is due to the double impact of energy price hikes on households-through direct impact on fuel bills and indirect impact on the prices of goods and services consumed. However, while examining the household energy cost burden of the elderly, their indirect energy consumption and associated cost burden remain...
Improving T cell killing and understanding senescence: Possible roles for TP53 in cancer immunotherapy
No abstract
Polr3b heterozygosity in mice induces both beneficial and deleterious effects on health during ageing with no effect on lifespan
The genetic pathways that modulate ageing in multicellular organisms are typically highly conserved across wide evolutionary distances. Recently RNA polymerase III (Pol III) was shown to promote ageing in yeast, C. elegans and D. melanogaster. In this study we investigated the role of Pol III in mammalian ageing using C57BL/6N mice heterozygous for Pol III (Polr3b^(+/-) ). We identified sexually dimorphic, organ-specific beneficial as well as detrimental effects of the Polr3b^(+/-) mutation on...
Congress is using more science, but the two parties rarely cite the same studies
Democrats reference papers more often than Republicans, and the shared base of research to inform policymaking is small
Biden’s lean science budget could mean tough choices for agencies
President abides by tight spending cap in his 2025 request to Congress