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Origins and diversity of Greenland’s Qimmit revealed with genomes of ancient and modern sled dogs
Science, Volume 389, Issue 6756, Page 163-168, July 2025.
Single- and multithread rivers originate from (im)balance between lateral erosion and accretion
Science, Volume 389, Issue 6756, Page 146-150, July 2025.
Discrete spatiotemporal encoding of striatal dopamine transmission
Science, Volume 389, Issue 6756, Page 200-206, July 2025.
ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox
Science, Volume 389, Issue 6756, Page 157-162, July 2025.
Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage
Science, Volume 389, Issue 6756, Page 169-175, July 2025.
Following in our footsteps
Science, Volume 389, Issue 6756, Page 132-132, July 2025.
The boundless energy, and ego, of Luis Alvarez
Science, Volume 389, Issue 6756, Page 133-133, July 2025.
Spin-filter tunneling detection of antiferromagnetic resonance with electrically tunable damping
Science, Volume 389, Issue 6759, Page 479-482, July 2025.
Negative capacitance overcomes Schottky-gate limits in GaN high-electron-mobility transistors
Science, Volume 389, Issue 6759, Page 508-511, July 2025.
NASA Earth Science Division provides key data
Science, Volume 389, Issue 6758, Page 357-358, July 2025.
U.S. abandons hunt for signal of cosmic inflation
Now-canceled CMB-S4 project would have searched the afterglow of the Big Bang for signs of cosmic exponential growth spurt
Genetic testing of critically ill adults can yield surprises—and reveal disparities in treatment of Black patients
Adults in the ICU often don’t know about the genetic diagnoses related to their symptoms, DNA sequencing study shows
How hydrogen-leaking ‘fairy circles’ might form
Understanding the origins of mysterious seeps could help prospectors extract natural hydrogen fuel
NIH director is replacing his top outside advisory board
Some worry new members of the long-running Advisory Committee to the Director will mirror agency chief Jay Bhattacharya’s views
Senate spending panel would rescue NSF and NASA science funding
Its support for a flat budget is a sign of congressional resistance to drastic cuts Trump has proposed
Quantum computers made of individual atoms leap to the fore
After decades in the doldrums, atom-based machines could overtake rival technologies
How short peptides disassemble tau fibrils in Alzheimer's disease
Reducing fibrous aggregates of the protein tau is a possible strategy for halting the progression of Alzheimer's disease (AD)¹. Previously, we found that in vitro, the D-enantiomeric peptide (D-peptide) D-TLKIVWC disassembles ultra-stable tau fibrils extracted from the autopsied brains of individuals with AD (hereafter, these tau fibrils are referred to as AD-tau) into benign segments, with no energy source other than ambient thermal agitation². To consider D-peptide-mediated disassembly as a...
Plasma proteomics links brain and immune system aging with healthspan and longevity
Plasma proteins derived from specific organs can estimate organ age and mortality, but their sensitivity to environmental factors and their robustness in forecasting onset of organ diseases and mortality remain unclear. To address this gap, we estimate the biological age of 11 organs using plasma proteomics data (2,916 proteins) from 44,498 individuals in the UK Biobank. Organ age estimates were sensitive to lifestyle factors and medications and were associated with future onset (within 17...
Corrigendum to "Assessment of muscle function deterioration in aging populations: Insights from the load-velocity relationship during the loaded sit-to-stand test" [Exp. Gerontol. 206 (2025) 112767]
No abstract
Early-life exercise extends healthspan but not lifespan in mice
It is well-known that physical activity exerts health benefits, yet the potential impacts of early-life regular exercise on later-life health and lifespan remains poorly understood. Here, we demonstrate that 3 months of early-life exercise in mice results in lasting health benefits, extending healthspan, but not lifespan. C57BL/6J mice underwent swimming exercise from 1 to 4 months of age, followed by detraining for the remainder of their lives. While early-life exercise did not extend the...